Bats host major mammalian paramyxoviruses.

Jan Felix Drexler (1) , Victor Max Corman (1) , Marcel Alexander Müller (1) , Gael Darren Maganga (2) , Peter Vallo (3) , Tabea Binger (1) , Florian Gloza-Rausch (1, 4) , Andrea Rasche (5) , Stoian Yordanov (6) , Antje Seebens (4) , Samuel Oppong (7) , Yaw Adu Sarkodie (7) , Célestin Pongombo (8) , Alexander N Lukashev (9) , Jonas Schmidt-Chanasit (10) , Andreas Stöcker (11) , Aroldo José Borges Carneiro (12) , Stephanie Erbar (13) , Andrea Maisner (13) , Florian Fronhoffs (14) , Reinhard Buettner (14, 15) , Elisabeth K V Kalko (16, 17) , Thomas Kruppa (18) , Carlos Roberto Franke (12) , René Kallies (1) , Emmanuel R N Yandoko (19) , Georg Herrler (5) , Chantal Reusken (20) , Alexandre Hassanin (21) , Detlev H Krüger (22) , Sonja Matthee (23) , Rainer G Ulrich (24) , Eric M Leroy (2, 25) , Christian Drosten (1)

1 Institute of Virology
2 CIRMF - Centre International de Recherches Médicales de Franceville
3 Institute of Vertebrate Biology
4 Noctalis
5 Institute of Virology [Hannover]
6 Forestry Board Directorate of Strandja Natural Park
7 KNUST - Kwame Nkrumah University of Science and Technology
8 UNILU - Université de Lubumbashi
9 Chumakov Institute of Poliomyelitis and Viral Encephalitides
10 Department of Virology
11 Infectious Diseases Research Laboratory
12 School of Veterinary Medicine
13 Institut für Virologie
14 Institute of Pathology
15 Institute of Pathology
16 Smithsonian Tropical Research Institute
17 Institute of Experimental Ecology
18 KCCR - Kumasi Centre for Collaborative Research in Tropical Medicine
19 Institut Pasteur de Bangui
20 Netherlands Center for Infectious Disease Control
21 MNHN - Muséum national d'Histoire naturelle
22 Institute of Medical Virology (Helmut Ruska Haus)
23 Department of Conservation Ecology and Entomology
24 INNT - Institute of Novel and Emerging Infectious Diseases
25 IRD [France-Sud] - Institut de Recherche pour le Développement

The large virus family Paramyxoviridae includes some of the most significant human and livestock viruses, such as measles-, distemper-, mumps-, parainfluenza-, Newcastle disease-, respiratory syncytial virus and metapneumoviruses. Here we identify an estimated 66 new paramyxoviruses in a worldwide sample of 119 bat and rodent species (9,278 individuals). Major discoveries include evidence of an origin of Hendra- and Nipah virus in Africa, identification of a bat virus conspecific with the human mumps virus, detection of close relatives of respiratory syncytial virus, mouse pneumonia- and canine distemper virus in bats, as well as direct evidence of Sendai virus in rodents. Phylogenetic reconstruction of host associations suggests a predominance of host switches from bats to other mammals and birds. Hypothesis tests in a maximum likelihood framework permit the phylogenetic placement of bats as tentative hosts at ancestral nodes to both the major Paramyxoviridae subfamilies (Paramyxovirinae and Pneumovirinae). Future attempts to predict the emergence of novel paramyxoviruses in humans and livestock will have to rely fundamentally on these data.

Domaines: Virologie

Jan Felix Drexler, Victor Max Corman, Marcel Alexander Müller, Gael Darren Maganga, Peter Vallo, et al.. Bats host major mammalian paramyxoviruses.. Nature Communications, 2012, 3, pp.796. ⟨10.1038/ncomms1796⟩. ⟨pasteur-00700110⟩