Virology and cell biology of the hepatitis C virus life cycle: an update.

Jean Dubuisson 1, * François-Loïc Cosset 2, 3, *
* Corresponding author
3 LabEx ECOFECT Inserm U1111
CIRI - Centre International de Recherche en Infectiologie - UMR
Abstract : Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis and hepatocellular carcinoma. It imposes a serious problem to public health in the world as the population of chronically infected HCV patients who are at risk of progressive liver disease is projected to increase significantly in the next decades. However, the arrival of new antiviral molecules is progressively changing the landscape of hepatitis C treatment. The search for new anti-HCV therapies has also been a driving force to better understand how HCV interacts with its host, and major progresses have been made on the various steps of the HCV life cycle. Here, we review the most recent advances in the fast growing knowledge on HCV life cycle and interaction with host factors and pathways.
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Jean Dubuisson, François-Loïc Cosset. Virology and cell biology of the hepatitis C virus life cycle: an update.. Journal of Hepatology, Elsevier, 2014, Journal of Hepatology Update: Hepatitis C, 61 (1 Suppl), pp.S3-S13. ⟨10.1016/j.jhep.2014.06.031⟩. ⟨hal-01140479⟩



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