D. L. Thomas, Global control of hepatitis C: where challenge meets opportunity, Nat Med, vol.19, pp.850-858, 2013.

M. P. Manns, J. G. Mchutchison, S. C. Gordon, V. K. Rustgi, M. Shiffman et al., Peginterferon alfa-2b plus ribavirin compared with interferon alfa2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial, Lancet, vol.358, pp.958-965, 2001.

J. G. Mchutchison, S. C. Gordon, E. R. Schiff, M. L. Shiffman, W. M. Lee et al., Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group, N Engl J Med, vol.339, pp.1485-1492, 1998.

M. W. Fried, M. L. Shiffman, K. R. Reddy, C. Smith, G. Marinos et al., Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection, N Engl J Med, vol.347, pp.975-982, 2002.

J. M. Pawlotsky, New hepatitis C therapies: the toolbox, strategies, and challenges, Gastroenterology, vol.146, pp.1176-1192, 2014.

Q. Choo, G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley et al., Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome, Science, vol.244, pp.359-362, 1989.

J. F. Drexler, V. M. Corman, M. A. Muller, A. N. Lukashev, A. Gmyl et al., Evidence for novel hepaciviruses in rodents, PLoS Pathog, vol.9, p.1003438, 2013.

A. Kapoor, P. Simmonds, G. Gerold, N. Qaisar, K. Jain et al., Characterization of a canine homolog of hepatitis C virus, Proc Natl Acad Sci U S A, vol.108, pp.11608-11613, 2011.

A. Kapoor, P. Simmonds, T. K. Scheel, B. Hjelle, J. M. Cullen et al., Identification of rodent homologs of hepatitis C virus and pegiviruses, mBio, vol.4, pp.216-229, 2013.

P. L. Quan, C. Firth, J. M. Conte, S. H. Williams, C. M. Zambrana-torrelio et al., Bats are a major natural reservoir for hepaciviruses and pegiviruses, Proc Natl Acad Sci U S A, vol.110, pp.8194-8199, 2013.

P. Simmonds, The origin of hepatitis C virus, Curr Top Microbiol Immunol, vol.369, pp.1-15, 2013.

M. P. Manns, H. Wedemeyer, and M. Cornberg, Treating viral hepatitis C: efficacy, side effects, and complications, Gut, vol.55, pp.1350-1359, 2006.

N. N. Zein, Clinical significance of hepatitis C virus genotypes, Clin Microbiol Rev, vol.13, pp.223-235, 2000.

J. Bukh, Animal models for the study of hepatitis C virus infection and related liver disease, Gastroenterology, vol.142, p.1273, 2012.

E. Billerbeck, Y. De-jong, M. Dorner, C. De-la-fuente, and A. Ploss, Animal models for hepatitis C, Curr Top Microbiol Immunol, vol.369, pp.49-86, 2013.

V. Lohmann, F. Korner, J. Koch, U. Herian, L. Theilmann et al., Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line, Science, vol.285, pp.110-113, 1999.

B. Bartosch, J. Dubuisson, and F. L. Cosset, Infectious hepatitis C pseudo-particles containing functional E1E2 envelope protein complexes, J Exp Med, vol.197, pp.633-642, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-00133783

B. D. Lindenbach, M. J. Evans, A. J. Syder, B. Wolk, T. L. Tellinghuisen et al., Complete replication of hepatitis C virus in cell culture, Science, vol.309, pp.623-626, 2005.

T. Wakita, T. Pietschmann, T. Kato, T. Date, M. Miyamoto et al., Production of infectious hepatitis C virus in tissue culture from a cloned viral genome, Nat Med, vol.11, pp.791-796, 2005.

J. Zhong, P. Gastaminza, G. Cheng, S. Kapadia, T. Kato et al., Robust hepatitis C virus infection in vitro, Proc Natl Acad Sci U S A, vol.102, pp.9294-9299, 2005.

S. J. Meex, U. Andreo, J. D. Sparks, and E. A. Fisher, Huh-7 or HepG2 cells: which is the better model for studying human apolipoprotein-B100 assembly and secretion?, J Lipid Res, vol.52, pp.152-158, 2011.

S. Lagaye, H. Shen, B. Saunier, M. Nascimbeni, J. Gaston et al., Efficient replication of primary or culture hepatitis C virus isolates in human liver slices: a relevant ex vivo model of liver infection, Hepatology, vol.56, pp.861-872, 2012.

A. Ploss, S. R. Khetani, C. T. Jones, A. J. Syder, K. Trehan et al., Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures, Proc Natl Acad Sci U S A, vol.107, pp.3141-3145, 2010.

P. Podevin, A. Carpentier, V. Pene, L. Aoudjehane, M. Carriere et al., Production of infectious hepatitis C virus in primary cultures of human adult hepatocytes, Gastroenterology, vol.139, pp.1355-1364, 2010.

P. Andre, F. Komurian-pradel, S. Deforges, M. Perret, J. L. Berland et al., Characterization of low-and very-low-density hepatitis C virus RNAcontaining particles, J Virol, vol.76, pp.6919-6928, 2002.

R. Thomssen, S. Bonk, C. Propfe, K. H. Heermann, H. G. Kochel et al., Association of hepatitis C virus in human sera with beta-lipoprotein, Med Microbiol Immunol, vol.181, pp.293-300, 1992.

R. Thomssen, S. Bonk, and A. Thiele, Density heterogeneities of hepatitis C virus in human sera due to the binding of beta-lipoproteins and immunoglobulins, Med Microbiol Immunol, vol.182, pp.329-334, 1993.

M. T. Catanese, K. Uryu, M. Kopp, T. J. Edwards, L. Andrus et al., Ultrastructural analysis of hepatitis C virus particles, Proc Natl Acad Sci U S A, vol.110, pp.9505-9510, 2013.

G. Vieyres, J. Dubuisson, and T. Pietschmann, Incorporation of hepatitis C virus e1 and e2 glycoproteins: the keystones on a peculiar virion, Viruses, vol.6, pp.1149-1187, 2014.

K. S. Chang, J. Jiang, Z. Cai, and G. Luo, Human apolipoprotein E is required for infectivity and production of hepatitis C virus in cell culture, J Virol, vol.81, pp.13783-13793, 2007.

J. C. Meunier, R. S. Russell, R. E. Engle, K. N. Faulk, R. H. Purcell et al., Apolipoprotein c1 association with hepatitis C virus, J Virol, vol.82, pp.9647-9656, 2008.

S. U. Nielsen, M. F. Bassendine, A. D. Burt, C. Martin, W. Pumeechockchai et al., Association between hepatitis C virus and very-low-density lipoprotein (VLDL)/LDL analyzed in iodixanol density gradients, J Virol, vol.80, pp.2418-2428, 2006.

A. Merz, G. Long, M. S. Hiet, B. Bruegger, P. Chlanda et al., Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome, J Biol Chem, vol.286, pp.3018-3032, 2011.

R. Bartenschlager, F. Penin, V. Lohmann, and P. Andre, Assembly of infectious hepatitis C virus particles, Trends Microbiol, vol.19, pp.95-103, 2011.

B. D. Lindenbach, Virion assembly and release, Curr Top Microbiol Immunol, vol.369, pp.199-218, 2013.

V. L. Dao-thi, C. Granier, M. B. Zeisel, M. Guerin, J. Mancip et al., Characterization of hepatitis C virus particle sub-populations reveals multiple usage of the scavenger receptor BI for entry steps, J Biol Chem, vol.287, pp.31242-31257, 2012.

G. Vieyres, X. Thomas, V. Descamps, G. Duverlie, A. H. Patel et al., Characterization of the envelope glycoproteins associated with infectious hepatitis C virus, J Virol, vol.84, pp.10159-10168, 2010.

P. Pileri, Y. Uematsu, S. Campagnoli, G. Galli, F. Falugi et al., Binding of hepatitis C virus to CD81, Science, vol.282, pp.938-941, 1998.

E. Scarselli, H. Ansuini, R. Cerino, R. M. Roccasecca, S. Acali et al., The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus, EMBO J, vol.21, pp.5017-5025, 2002.

T. Krey, J. Alayer, C. M. Kikuti, A. Saulnier, L. Damier-piolle et al., The disulfide bonds in glycoprotein E2 of hepatitis C virus reveal the tertiary organization of the molecule, PLoS Pathog, vol.6, p.1000762, 2010.
URL : https://hal.archives-ouvertes.fr/pasteur-00460826

L. Kong, E. Giang, T. Nieusma, R. U. Kadam, K. E. Cogburn et al., Hepatitis C virus E2 envelope glycoprotein core structure, Science, vol.342, pp.1090-1094, 2013.

A. G. Khan, J. Whidby, M. T. Miller, H. Scarborough, A. V. Zatorski et al., Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2, Nature, vol.509, pp.381-384, 2014.

F. Helle, G. Vieyres, L. Elkrief, C. I. Popescu, C. Wychowski et al., Role of N-linked glycans in the functions of HCV envelope proteins incorporated into infectious virions, J Virol, vol.84, pp.11905-11915, 2010.

A. M. Owsianka, J. M. Timms, A. W. Tarr, R. J. Brown, T. P. Hickling et al., Identification of conserved residues in the E2 envelope glycoprotein of the hepatitis C virus that are critical for CD81 binding, J Virol, vol.80, pp.8695-8704, 2006.

F. Douam, V. L. Dao-thi, G. Maurin, J. Fresquet, D. Mompelat et al., Critical interaction between E1 and E2 glycoproteins determines binding and fusion properties of hepatitis C virus during cell entry, Hepatology, vol.59, pp.776-788, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01010615

D. Lavillette, E. I. Pecheur, P. Donot, J. Fresquet, J. Molle et al., Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus, J Virol, vol.81, pp.8752-8765, 2007.

M. Lefevre, D. J. Felmlee, M. Parnot, T. F. Baumert, and C. Schuster, Syndecan 4 is involved in mediating HCV entry through interaction with lipoviral particle-associated apolipoprotein E, PLoS One, vol.9, p.95550, 2014.

Q. Shi, J. Jiang, and G. Luo, Syndecan-1 serves as the major receptor for attachment of hepatitis C virus to the surfaces of hepatocytes, J Virol, vol.87, pp.6866-6875, 2013.

H. Barth, C. Schafer, M. I. Adah, F. Zhang, R. J. Linhardt et al., Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate, J Biol Chem, vol.278, pp.41003-41012, 2003.

J. Jiang, X. Wu, H. Tang, and G. Luo, Apolipoprotein E mediates attachment of clinical hepatitis C virus to hepatocytes by binding to cell surface heparan sulfate proteoglycan receptors, PLoS One, vol.8, p.67982, 2013.

V. Agnello, G. Abel, M. Elfahal, G. B. Knight, and Q. Zhang, Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor, Proc Natl Acad Sci U S A, vol.96, pp.12766-12771, 1999.

A. Albecka, S. Belouzard, A. O. De-beeck, V. Descamps, L. Goueslain et al., Role of low-density lipoprotein receptor in the hepatitis C virus life cycle, Hepatology, vol.55, pp.998-1007, 2012.

M. J. Evans, T. Von-hahn, D. M. Tscherne, A. J. Syder, M. Panis et al., Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry, Nature, vol.446, pp.801-805, 2007.

A. Ploss, M. J. Evans, V. A. Gaysinskaya, M. Panis, H. You et al., Human occludin is a hepatitis C virus entry factor required for infection of mouse cells, Nature, vol.457, pp.882-886, 2009.

P. Maillard, T. Huby, U. Andreo, M. Moreau, J. Chapman et al., The interaction of natural hepatitis C virus with human scavenger receptor SR-BI/Cla1 is mediated by ApoB-containing lipoproteins, FASEB J, vol.20, pp.735-737, 2006.

M. N. Zahid, M. Turek, X. F. Thi, V. L. Guerin, M. Fofana et al., The postbinding activity of scavenger receptor class B type I mediates initiation of hepatitis C virus infection and viral dissemination, Hepatology, vol.57, pp.492-504, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-00850917

D. Bankwitz, E. Steinmann, J. Bitzegeio, S. Ciesek, M. Friesland et al., Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes, J Virol, vol.84, pp.5751-5763, 2010.

M. Dreux, V. L. Dao-thi, J. Fresquet, M. Guerin, J. Z. Verney et al., Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra-and extra-cellular domains, PLoS Pathog, vol.5, p.1000310, 2009.

J. Prentoe, T. B. Jensen, P. Meuleman, S. B. Serre, T. K. Scheel et al., Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization, J Virol, vol.85, pp.2224-2234, 2011.

L. Feneant, S. Levy, and L. Cocquerel, CD81 and hepatitis C virus (HCV) infection, Viruses, vol.6, pp.535-572, 2014.

N. R. Sharma, G. Mateu, M. Dreux, A. Grakoui, F. L. Cosset et al., Hepatitis C virus is primed by CD81 protein for low pH-dependent fusion, J Biol Chem, vol.286, pp.30361-30376, 2011.

H. J. Harris, C. Clerte, M. J. Farquhar, M. Goodall, K. Hu et al., Hepatoma polarization limits CD81 and hepatitis C virus dynamics, Cell Microbiol, vol.15, pp.430-445, 2013.

J. Potel, P. Rassam, C. Montpellier, L. Kaestner, E. Werkmeister et al., EWI-2wint promotes CD81 clustering that abrogates hepatitis C virus entry, Cell Microbiol, vol.15, pp.1234-1252, 2013.

H. J. Harris, C. Davis, J. G. Mullins, K. Hu, M. Goodall et al., Claudin association with CD81 defines hepatitis C virus entry, J Biol Chem, vol.285, pp.21092-21102, 2010.

H. J. Harris, M. J. Farquhar, C. J. Mee, C. Davis, G. M. Reynolds et al., CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry, J Virol, vol.82, pp.5007-5020, 2008.

M. J. Farquhar, K. Hu, H. J. Harris, C. Davis, C. L. Brimacombe et al., Hepatitis C virus induces CD81 and claudin-1 endocytosis, J Virol, vol.86, pp.4305-4316, 2012.

M. J. Farquhar, H. J. Harris, M. Diskar, S. Jones, C. J. Mee et al., Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity, J Virol, vol.82, pp.8797-8811, 2008.

J. Lupberger, M. B. Zeisel, F. Xiao, C. Thumann, I. Fofana et al., EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy, Nat Med, vol.17, pp.589-595, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00705829

S. Kim, H. Ishida, D. Yamane, M. Yi, D. C. Swinney et al., Contrasting roles of mitogen-activated protein kinases in cellular entry and replication of hepatitis C virus: MKNK1 facilitates cell entry, J Virol, vol.87, pp.4214-4224, 2013.

L. Zona, J. Lupberger, N. Sidahmed-adrar, C. Thumann, H. J. Harris et al., HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex, Cell Host Microbe, vol.13, pp.302-313, 2013.

Z. Liu, Y. Tian, K. Machida, M. M. Lai, G. Luo et al., Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry, J Biol Chem, vol.287, pp.41922-41930, 2012.

M. Brazzoli, A. Bianchi, S. Filippini, A. Weiner, Q. Zhu et al., CD81 is a central regulator of cellular events required for hepatitis C virus infection of human hepatocytes, J Virol, vol.82, pp.8316-8329, 2008.

I. Benedicto, F. Molina-jimenez, B. Bartosch, F. L. Cosset, D. Lavillette et al., The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infection, J Virol, vol.83, pp.8012-8020, 2009.

M. Sourisseau, M. L. Michta, C. Zony, B. Israelow, S. E. Hopcraft et al., Temporal analysis of hepatitis C virus cell entry with occludin directed blocking antibodies, PLoS Pathog, vol.9, p.1003244, 2013.

N. F. Fletcher, R. Sutaria, J. J. Barnes, A. Blahova, M. Meredith et al., Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner, Hepatology, vol.59, pp.1320-1330, 2014.

S. Liu, W. Yang, L. Shen, J. R. Turner, C. B. Coyne et al., Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection, J Virol, vol.83, pp.2011-2014, 2009.

M. Dorner, J. A. Horwitz, J. B. Robbins, W. T. Barry, Q. Feng et al., A genetically humanized mouse model for hepatitis C virus infection, Nature, vol.474, pp.208-211, 2011.

C. J. Mee, J. Grove, H. J. Harris, K. Hu, P. Balfe et al., Effect of cell polarization on hepatitis C virus entry, J Virol, vol.82, pp.461-470, 2008.

C. J. Mee, H. J. Harris, M. J. Farquhar, G. Wilson, G. Reynolds et al., Polarization restricts hepatitis C virus entry into HepG2 hepatoma cells, J Virol, vol.83, pp.6211-6221, 2009.

K. E. Coller, K. L. Berger, N. S. Heaton, J. D. Cooper, R. Yoon et al., RNA interference and single particle tracking analysis of hepatitis C virus endocytosis, PLoS Pathog, vol.5, p.1000702, 2009.

B. Sainz, N. Barretto, D. N. Martin, N. Hiraga, M. Imamura et al., Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor, Nat Med, vol.18, pp.281-285, 2012.

D. N. Martin and S. L. Uprichard, Identification of transferrin receptor 1 as a hepatitis C virus entry factor, Proc Natl Acad Sci U S A, vol.110, pp.10777-10782, 2013.

V. Rocha-perugini, C. Montpellier, D. Delgrange, C. Wychowski, F. Helle et al., The CD81 partner EWI-2wint inhibits hepatitis C virus entry, PLoS One, vol.3, p.1866, 2008.

V. L. Dao-thi, M. Dreux, and F. L. Cosset, Scavenger receptor class B type I and the hypervariable region-1 of hepatitis C virus in cell entry and neutralisation, Expert Rev Mol Med, vol.13, p.13, 2011.

S. W. Altmann, D. Jr, H. R. Zhu, L. J. Yao, X. Hoos et al., Niemannpick C1 like 1 protein is critical for intestinal cholesterol absorption, Science, vol.303, pp.1201-1204, 2004.

G. M. Reynolds, H. J. Harris, A. Jennings, K. Hu, J. Grove et al., Hepatitis C virus receptor expression in normal and diseased liver tissue, Hepatology, vol.47, pp.418-427, 2008.

E. Blanchard, S. Belouzard, L. Goueslain, T. Wakita, J. Dubuisson et al., Hepatitis C virus entry depends on clathrin-mediated endocytosis, J Virol, vol.80, pp.6964-6972, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00105504

S. Wieland, Z. Makowska, B. Campana, D. Calabrese, M. T. Dill et al., Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver, Hepatology, vol.59, pp.2121-2130, 2014.

C. L. Brimacombe, J. Grove, L. W. Meredith, K. Hu, A. J. Syder et al., Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission, J Virol, vol.85, pp.596-605, 2011.

M. T. Catanese, J. Loureiro, C. T. Jones, M. Dorner, T. Von-hahn et al., Different requirements for scavenger receptor class B type I in hepatitis C virus cellfree vs. cell-to-cell transmission, J Virol, vol.87, pp.8282-8293, 2013.

J. M. Timpe, Z. Stamataki, A. Jennings, K. Hu, M. J. Farquhar et al., Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies, Hepatology, vol.47, pp.17-24, 2008.

J. Witteveldt, M. J. Evans, J. Bitzegeio, G. Koutsoudakis, A. M. Owsianka et al., CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells, J Gen Virol, vol.90, pp.48-58, 2009.

V. Ramakrishnaiah, C. Thumann, I. Fofana, F. Habersetzer, Q. Pan et al., Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells, Proc Natl Acad Sci U S A, vol.110, pp.13109-13113, 2013.

M. Niepmann, Hepatitis C virus RNA translation, Curr Top Microbiol Immunol, vol.369, pp.143-166, 2013.

V. Lohmann, Hepatitis C virus RNA replication, Curr Top Microbiol Immunol, vol.369, pp.167-198, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00313684

D. Moradpour and F. Penin, Hepatitis C virus proteins: from structure to function, Curr Top Microbiol Immunol, vol.369, pp.113-142, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00972585

C. L. Jopling, M. Yi, A. M. Lancaster, S. M. Lemon, and P. Sarnow, Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA, Science, vol.309, pp.1577-1581, 2005.

T. Shimakami, D. Yamane, R. K. Jangra, B. J. Kempf, C. Spaniel et al., Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex, Proc Natl Acad Sci U S A, vol.109, pp.941-946, 2012.

Y. Li, T. Masaki, D. Yamane, D. R. Mcgivern, and S. M. Lemon, Competing and noncompeting activities of miR-122 and the 5 0 exonuclease Xrn1 in regulation of hepatitis C virus replication, Proc Natl Acad Sci U S A, vol.110, pp.1881-1886, 2013.

I. Romero-brey, A. Merz, A. Chiramel, J. Y. Lee, P. Chlanda et al., Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication, PLoS Pathog, vol.8, p.1003056, 2012.

P. Ferraris, E. Blanchard, and P. Roingeard, Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes, J Gen Virol, vol.91, pp.2230-2237, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00510829

M. Hilaire, E. Décembre, and M. Dreux, Autophagy: a home remodeler for hepatitis C virus, 2014.

M. Dreux and F. V. Chisari, Impact of the autophagy machinery on hepatitis C virus infection, Viruses, vol.3, pp.1342-1357, 2011.

J. Gouttenoire, P. Roingeard, F. Penin, and D. Moradpour, Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B, J Virol, vol.84, pp.12529-12537, 2010.

D. Egger, B. Wölk, R. Gosert, L. Bianchi, H. E. Blum et al., Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex, J Virol, vol.76, pp.5974-5984, 2002.

S. Reiss, I. Rebhan, P. Backes, I. Romero-brey, H. Erfle et al., Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment, Cell Host Microbe, vol.9, pp.32-45, 2011.

A. Shulla and G. Randall, Hepatitis C virus-host interactions, replication, and viral assembly, Curr Opin Virol, vol.2, pp.725-732, 2012.

M. A. Germain, L. Chatel-chaix, B. Gagne, E. Bonneil, P. Thibault et al., Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches, Mol Cell Proteomics, vol.13, pp.184-203, 2014.

S. Reiss, C. Harak, I. Romero-brey, D. Radujkovic, R. Klein et al., The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A, PLoS Pathog, vol.9, p.1003359, 2013.

H. Li, X. Yang, G. Yang, Z. Hong, L. Zhou et al., Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a PI4P-enriched microenvironment, J Virol, vol.88, pp.5956-5966, 2014.

D. Paul, S. Hoppe, G. Saher, J. Krijnse-locker, and R. Bartenschlager, Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment, J Virol, vol.87, pp.10612-10627, 2013.

H. Wang, J. W. Perry, A. S. Lauring, P. Neddermann, D. Francesco et al., Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking, Gastroenterology, vol.146, pp.1373-1385, 2014.

D. L. Diamond, A. J. Syder, J. M. Jacobs, C. M. Sorensen, K. A. Walters et al., Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics, PLoS Pathog, vol.6, p.1000719, 2010.

V. Madan, D. Paul, V. Lohmann, and R. Bartenschlager, Inhibition of HCV replication by cyclophilin antagonists is linked to replication fitness and occurs by inhibition of membranous web formation, Gastroenterology, vol.146, pp.1361-1372, 2014.

C. J. Neufeldt, M. A. Joyce, A. Levin, R. H. Steenbergen, D. Pang et al., Hepatitis C virus-induced cytoplasmic organelles use the nuclear transport machinery to establish an environment conducive to virus replication, PLoS Pathog, vol.9, p.1003744, 2013.

Y. Miyanari, K. Atsuzawa, N. Usuda, K. Watashi, T. Hishiki et al., The lipid droplet is an important organelle for hepatitis C virus production, Nat Cell Biol, vol.9, pp.1089-1097, 2007.

P. Targett-adams, S. Boulant, and J. Mclauchlan, Visualization of double-stranded RNA in cells supporting hepatitis C virus RNA replication, J Virol, vol.82, pp.2182-2195, 2008.

S. Salloum, H. Wang, C. Ferguson, R. G. Parton, and A. W. Tai, Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets, PLoS Pathog, vol.9, p.1003513, 2013.

D. Ploen, M. L. Hafirassou, K. Himmelsbach, D. Sauter, M. L. Biniossek et al., TIP47 plays a crucial role in the life cycle of hepatitis C virus, J Hepatol, vol.58, pp.1081-1088, 2013.

D. A. Vogt, G. Camus, E. Herker, B. R. Webster, C. L. Tsou et al., Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein, PLoS Pathog, vol.9, p.1003302, 2013.

N. S. Eyre, G. N. Fiches, A. L. Aloia, K. J. Helbig, E. M. Mccartney et al., Dynamic imaging of the hepatitis C virus NS5A protein during a productive infection, J Virol, vol.88, pp.3636-3652, 2014.

S. Boulant, C. Vanbelle, C. Ebel, F. Penin, and J. P. Lavergne, Hepatitis C virus core protein is a dimeric alpha-helical protein exhibiting membrane protein features, J Virol, vol.79, pp.11353-11365, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00313681

G. Barba, F. Harper, T. Harada, M. Kohara, S. Goulinet et al., Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets, Proc Natl Acad Sci U S A, vol.94, pp.1200-1205, 1997.

D. Moradpour, C. Englert, T. Wakita, and J. R. Wands, Characterization of cell lines allowing tightly regulated expression of hepatitis C virus core protein, Virology, vol.222, pp.51-63, 1996.

S. Boulant, R. Montserret, G. Hope, M. Ratinier, P. Targett-adams et al., Structural determinants that target the hepatitis C virus core protein to lipid droplets, J Biol Chem, vol.281, pp.22236-22247, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00313671

S. Boulant, M. W. Douglas, L. Moody, A. Budkowska, P. Targett-adams et al., Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule-and dynein-dependent manner, Traffic, vol.9, pp.1268-1282, 2008.

S. Boulant, P. Targett-adams, and J. Mclauchlan, Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus, J Gen Virol, vol.88, pp.2204-2213, 2007.

A. Shavinskaya, S. Boulant, F. Penin, J. Mclauchlan, and R. Bartenschlager, The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly, J Biol Chem, vol.282, pp.37158-37169, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00315148

N. A. Counihan, S. M. Rawlinson, and B. D. Lindenbach, Trafficking of hepatitis C virus core protein during virus particle assembly, PLoS Pathog, vol.7, p.1002302, 2011.

B. Boson, O. Granio, R. Bartenschlager, and F. L. Cosset, A concerted action of hepatitis C virus p7 and nonstructural protein 2 regulates core localization at the endoplasmic reticulum and virus assembly, PLoS Pathog, vol.7, p.1002144, 2011.

E. Herker, C. Harris, C. Hernandez, A. Carpentier, K. Kaehlcke et al., Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1, Nat Med, vol.16, pp.1295-1298, 2010.

N. Menzel, W. Fischl, K. Hueging, D. Bankwitz, A. Frentzen et al., MAPkinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles, PLoS Pathog, vol.8, p.1002829, 2012.

Q. Li, V. Pene, S. Krishnamurthy, H. Cha, and T. J. Liang, Hepatitis C virus infection activates an innate pathway involving IKK-alpha in lipogenesis and viral assembly, Nat Med, vol.19, pp.722-729, 2013.

G. Neveu, R. Barouch-bentov, A. Ziv-av, D. Gerber, Y. Jacob et al., Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly, PLoS Pathog, vol.8, p.1002845, 2012.

J. Dubuisson, H. H. Hsu, R. C. Cheung, H. B. Greenberg, D. G. Russell et al., Formation and intracellular localization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia and Sindbis viruses, J Virol, vol.68, pp.6147-6160, 1994.

V. Jirasko, R. Montserret, J. Y. Lee, J. Gouttenoire, D. Moradpour et al., Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly, PLoS Pathog, vol.6, p.1001233, 2010.

Y. Ma, M. Anantpadma, J. M. Timpe, S. Shanmugam, S. M. Singh et al., Hepatitis C virus NS2 protein serves as a scaffold for virus assembly by interacting with both structural and nonstructural proteins, J Virol, vol.85, pp.86-97, 2011.

C. I. Popescu, N. Callens, D. Trinel, P. Roingeard, D. Moradpour et al., NS2 protein of hepatitis C virus interacts with structural and nonstructural proteins towards virus assembly, PLoS Pathog, vol.7, p.1001278, 2011.

K. A. Stapleford and B. D. Lindenbach, Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes, J Virol, vol.85, pp.1706-1717, 2011.

R. Suzuki, M. Matsuda, K. Watashi, H. Aizaki, Y. Matsuura et al., Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2, PLoS Pathog, vol.9, p.1003589, 2013.

J. Gentzsch, C. Brohm, E. Steinmann, M. Friesland, N. Menzel et al., Hepatitis C virus p7 is critical for capsid assembly and envelopment, PLoS Pathog, vol.9, p.1003355, 2013.

N. Appel, M. Zayas, S. Miller, J. Krijnse-locker, T. Schaller et al., Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly, PLoS Pathog, vol.4, p.1000035, 2008.

T. Masaki, R. Suzuki, K. Murakami, H. Aizaki, K. Ishii et al., Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles, J Virol, vol.82, pp.7964-7976, 2008.

T. L. Tellinghuisen, K. L. Foss, and J. Treadaway, Regulation of hepatitis C virion production via phosphorylation of the NS5A protein, PLoS Pathog, vol.4, p.1000032, 2008.

T. K. Scheel, J. Prentoe, T. H. Carlsen, L. S. Mikkelsen, J. M. Gottwein et al., Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems, PLoS Pathog, vol.8, p.1002696, 2012.

G. Camus, E. Herker, A. A. Modi, J. T. Haas, H. R. Ramage et al., Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core, J Biol Chem, vol.288, pp.9915-9923, 2013.

T. Phan, A. Kohlway, P. Dimberu, A. M. Pyle, and B. D. Lindenbach, The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly, J Virol, vol.85, pp.1193-1204, 2011.

T. Pietschmann, M. Zayas, P. Meuleman, G. Long, N. Appel et al., Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations, PLoS Pathog, vol.5, p.1000475, 2009.

G. Mousseau, S. Kota, V. Takahashi, D. N. Frick, and A. D. Strosberg, Dimerizationdriven interaction of hepatitis C virus core protein with NS3 helicase, J Gen Virol, vol.92, pp.101-111, 2011.

D. M. Jones, A. M. Atoom, X. Zhang, S. Kottilil, and R. S. Russell, A genetic interaction between the core and NS3 proteins of hepatitis C virus is essential for production of infectious virus, J Virol, vol.85, pp.12351-12361, 2011.

L. Chatel-chaix, P. Melancon, M. E. Racine, M. Baril, and D. Lamarre, Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production, J Virol, vol.85, pp.11022-11037, 2011.

H. Gouklani, R. A. Bull, C. Beyer, F. Coulibaly, E. J. Gowans et al., Hepatitis C virus nonstructural protein 5B is involved in virus morphogenesis, J Virol, vol.86, pp.5080-5088, 2012.

D. M. Jones, A. H. Patel, P. Targett-adams, and J. Mclauchlan, The hepatitis C virus NS4B protein can trans-complement viral RNA replication and modulates production of infectious virus, J Virol, vol.83, pp.2163-2177, 2009.

P. Gastaminza, G. Cheng, S. Wieland, J. Zhong, W. Liao et al., Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion, J Virol, vol.82, pp.2120-2129, 2008.

H. Huang, F. Sun, D. M. Owen, W. Li, Y. Chen et al., Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins, Proc Natl Acad Sci U S A, vol.104, pp.5848-5853, 2007.

Y. Nahmias, J. Goldwasser, M. Casali, D. Van-poll, T. Wakita et al., Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin, Hepatology, vol.47, pp.1437-1445, 2008.

X. Li, H. Jiang, L. Qu, W. Yao, H. Cai et al., Hepatocyte nuclear factor 4alpha and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus, J Virol, vol.88, pp.612-627, 2014.

H. Yao and J. Ye, Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells, J Biol Chem, vol.283, pp.849-854, 2008.

D. Costa, D. Turek, M. Felmlee, D. J. Girardi, E. Pfeffer et al., Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells, J Virol, vol.86, pp.11919-11925, 2012.
URL : https://hal.archives-ouvertes.fr/inserm-00734834

K. Hueging, M. Doepke, G. Vieyres, D. Bankwitz, A. Frentzen et al., Apolipoprotein E codetermines tissue tropism of hepatitis C virus and is crucial for viral cell-to-cell transmission by contributing to a postenvelopment step of assembly, J Virol, vol.88, pp.1433-1446, 2014.

J. Jiang and G. Luo, Apolipoprotein E but not B is required for the formation of infectious hepatitis C virus particles, J Virol, vol.83, pp.12680-12691, 2009.

K. E. Coller, N. S. Heaton, K. L. Berger, J. D. Cooper, J. L. Saunders et al., Molecular determinants and dynamics of hepatitis C virus secretion, PLoS Pathog, vol.8, p.1002466, 2012.

L. Corless, C. M. Crump, S. D. Griffin, and M. Harris, Vps4 and the ESCRT-III complex are required for the release of infectious hepatitis C virus particles, J Gen Virol, vol.91, pp.362-372, 2010.

K. Tamai, M. Shiina, N. Tanaka, T. Nakano, A. Yamamoto et al., Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway, Virology, vol.422, pp.377-385, 2012.

Y. Ariumi, M. Kuroki, M. Maki, M. Ikeda, H. Dansako et al., The ESCRT system is required for hepatitis C virus production, PLoS One, vol.6, p.14517, 2011.

S. Welsch, B. Muller, and H. G. Krausslich, More than one door -Budding of enveloped viruses through cellular membranes, FEBS Lett, vol.581, pp.2089-2097, 2007.

M. Dreux, U. Garaigorta, B. Boyd, E. Decembre, J. Chung et al., Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity, Cell Host Microbe, vol.12, pp.558-570, 2012.

P. Gastaminza, S. B. Kapadia, and F. V. Chisari, Differential biophysical properties of infectious intracellular and secreted hepatitis C virus particles, J Virol, vol.80, pp.11074-11081, 2006.

A. L. Wozniak, S. Griffin, D. Rowlands, M. Harris, M. Yi et al., Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production, PLoS Pathog, vol.6, p.1001087, 2010.