Drug-resistant tuberculosis in Eastern Europe: challenges and ways forward, Public Health Action, vol.4, issue.2, pp.3-12, 2014. ,
DOI : 10.5588/pha.14.0087
Multidrug-resistant and extensively drug-resistant tuberculosis: a review of current concepts and future challenges, Clinical Medicine, vol.14, issue.3, pp.279-28514, 2014. ,
DOI : 10.7861/clinmedicine.14-3-279
Novel approaches to tuberculosis vaccine development, International Journal of Infectious Diseases, vol.56, pp.263-267, 2017. ,
DOI : 10.1016/j.ijid.2016.10.018
URL : https://doi.org/10.1016/j.ijid.2016.10.018
Raising awareness of the importance of funding for tuberculosis small-molecule research, Drug Discovery Today, vol.22, issue.3, pp.487-491, 2017. ,
DOI : 10.1016/j.drudis.2016.09.012
Experimental Models of Foamy Macrophages and Approaches for Dissecting the Mechanisms of Lipid Accumulation and Consumption during Dormancy and Reactivation of Tuberculosis, Frontiers in Cellular and Infection Microbiology, vol.24, issue.98, 2016. ,
DOI : 10.1016/j.ceb.2012.05.012
URL : https://hal.archives-ouvertes.fr/hal-01455789
Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis, Tuberculosis, vol.83, issue.1-3, pp.91-97, 2003. ,
DOI : 10.1016/S1472-9792(02)00089-6
Bacterial Growth and Cell Division: a Mycobacterial Perspective, Microbiology and Molecular Biology Reviews, vol.72, issue.1, pp.126-15600028, 2008. ,
DOI : 10.1128/MMBR.00028-07
Advances in the development of new tuberculosis drugs and treatment regimens, Nature Reviews Drug Discovery, vol.109, issue.5, pp.388-404, 2013. ,
DOI : 10.1073/pnas.1205735109
Cyclophostin, acetylocholinesterase inhibitor from Streptomyces lavendulae., The Journal of Antibiotics, vol.46, issue.8, pp.1315-13181315, 1993. ,
DOI : 10.7164/antibiotics.46.1315
Cyclipostins, Novel Hormone-sensitive Lipase Inhibitors from Streptomyces sp. DSM 13381. II. Isolation, Structure Elucidation and Biological Properties., The Journal of Antibiotics, vol.55, issue.5, pp.480-494, 2002. ,
DOI : 10.7164/antibiotics.55.480
Treating mycobacterial infections with cyclipostins. Sanofi-Aventis Deutschland GmbH patent WO, p.25449, 2008. ,
Synthesis and Biological Evaluation of a Phosphonate Analog of the Natural Acetyl Cholinesterase Inhibitor Cyclophostin, The Journal of Organic Chemistry, vol.73, issue.21, pp.8386-8391, 2008. ,
DOI : 10.1021/jo801453v
The First Total Synthesis of (??)-Cyclophostin and (??)-Cyclipostin P: Inhibitors of the Serine Hydrolases Acetyl Cholinesterase and Hormone Sensitive Lipase, Organic Letters, vol.13, issue.12, pp.3094-3097, 2011. ,
DOI : 10.1021/ol200991x
Synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of human acetylcholinesterase, Bioorganic & Medicinal Chemistry, vol.18, issue.6, pp.2265-2274, 2010. ,
DOI : 10.1016/j.bmc.2010.01.063
Synthesis and Kinetic Evaluation of Cyclophostin and Cyclipostins Phosphonate Analogs As Selective and Potent Inhibitors of Microbial Lipases, Journal of Medicinal Chemistry, vol.55, issue.22, pp.10204-10219, 2012. ,
DOI : 10.1021/jm301216x
Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin, Bioorganic & Medicinal Chemistry, vol.23, issue.24, pp.7529-7534044, 2015. ,
DOI : 10.1016/j.bmc.2015.10.044
Rat hormone sensitive lipase inhibition by cyclipostins and their analogs, Bioorganic & Medicinal Chemistry, vol.23, issue.5, pp.944-952028, 2015. ,
DOI : 10.1016/j.bmc.2015.01.028
URL : http://europepmc.org/articles/pmc4340684?pdf=render
High Content Screening Identifies Decaprenyl-Phosphoribose 2??? Epimerase as a Target for Intracellular Antimycobacterial Inhibitors, PLoS Pathogens, vol.149, issue.10, 2009. ,
DOI : 10.1371/journal.ppat.1000645.s010
Ethionamide Boosters: Synthesis, Biological Activity, and Structure???Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors, Journal of Medicinal Chemistry, vol.54, issue.8, pp.2994-3010, 2011. ,
DOI : 10.1021/jm200076a
Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry, Annual Review of Biochemistry, vol.77, issue.1, pp.383-414, 2008. ,
DOI : 10.1146/annurev.biochem.75.101304.124125
Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes, 9<1067::AID- PROT1067>3.0.CO, pp.1067-10712, 2001. ,
DOI : 10.1002/1615-9861(200109)1:9<1067::AID-PROT1067>3.0.CO;2-4
Activity-based protein profiling: The serine hydrolases, Proceedings of the National Academy of Sciences, vol.19, issue.11, pp.14694-14699, 1999. ,
DOI : 10.1002/elps.1150191103
URL : http://www.pnas.org/content/96/26/14694.full.pdf
Discovering potent and selective reversible inhibitors of enzymes in complex proteomes, Nature Biotechnology, vol.9, issue.6, pp.687-691, 2003. ,
DOI : 10.1016/S1074-5521(02)00248-X
Targeting Lipid Esterases in Mycobacteria Grown Under Different Physiological Conditions Using Activity-based Profiling with Tetrahydrolipstatin (THL), Molecular & Cellular Proteomics, vol.18, issue.2, pp.435-448, 2014. ,
DOI : 10.1039/c0cc01276a
Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases, MedChemComm, vol.7, issue.4, pp.1797-1801, 2016. ,
DOI : 10.1371/journal.pone.0046493
URL : http://pubs.rsc.org/en/content/articlepdf/2016/md/c6md00231e
Systematic Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis Defines Changes Associated with Persistence, Cell Chemical Biology, vol.23, issue.2, pp.290-298, 2016. ,
DOI : 10.1016/j.chembiol.2016.01.003
Evidence for Diversifying Selection in a Set of Mycobacterium tuberculosis Genes in Response to Antibiotic- and Nonantibiotic-Related Pressure, Molecular Biology and Evolution, vol.7, issue.6, pp.1326-1336, 2013. ,
DOI : 10.1089/10665270050081478
Structural and Functional Characterization of Rv2966c Protein Reveals an RsmD-like Methyltransferase from Mycobacterium tuberculosis and the Role of Its N-terminal Domain in Target Recognition, The Journal of Biological Chemistry, vol.286, 2011. ,
Abstract, Biological Chemistry, vol.394, issue.7, pp.871-8771515, 2013. ,
DOI : 10.1515/hsz-2013-0126
: testing a putative role in menaquinone biosynthesis, Acta Crystallographica Section D Biological Crystallography, vol.57, issue.8, pp.909-917, 2010. ,
DOI : 10.1107/S0907444910025771
H37Rv and its Probable Role in Xenobiotic Degradation, Journal of Cellular Biochemistry, vol.3, issue.2, pp.390-40125285, 2016. ,
DOI : 10.1371/journal.pone.0002375
Expression and characterization of the protein Rv1399c from Mycobacterium tuberculosis, European Journal of Biochemistry, vol.34, issue.19, pp.3953-3961, 2004. ,
DOI : 10.1016/0005-2760(88)90036-7
Characterization of an acid inducible lipase Rv3203 from Mycobacterium tuberculosis H37Rv, Molecular Biology Reports, vol.257, issue.23, pp.285-296, 2014. ,
DOI : 10.1371/journal.pone.0004281
possibly involved in the metabolism of host cell membrane lipids, Biochemical Journal, vol.408, issue.3, pp.417-427, 2007. ,
DOI : 10.1042/BJ20070745
A Monoacylglycerol Lipase from Mycobacterium smegmatis Involved in Bacterial Cell Interaction, Journal of Bacteriology, vol.192, issue.18, pp.4776-478500261, 2010. ,
DOI : 10.1128/JB.00261-10
show very different lipolytic activities reflecting their physiological function, The FASEB Journal, vol.24, issue.6, pp.1893-190309, 2010. ,
DOI : 10.1111/j.1365-2958.2007.05761.x
URL : https://hal.archives-ouvertes.fr/hal-00497518
Identification of Residues Involved in Substrate Specificity and Cytotoxicity of Two Closely Related Cutinases from Mycobacterium tuberculosis, PLoS ONE, vol.1791, issue.7, 2013. ,
DOI : 10.1371/journal.pone.0066913.t003
Characterization of a Novel Esterase Rv0045c from Mycobacterium tuberculosis, PLoS ONE, vol.5, issue.10, 2010. ,
DOI : 10.1371/journal.pone.0013143.t001
Genes required for mycobacterial growth defined by high density mutagenesis, Molecular Microbiology, vol.1, issue.Suppl 1), pp.77-84, 2003. ,
DOI : 10.1099/00221287-113-2-409
URL : http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2958.2003.03425.x/pdf
The mycobacterial antigens 85 complex ??? from structure to function and beyond: Response, Trends in Microbiology, vol.8, issue.10, pp.966-842, 2000. ,
DOI : 10.1016/S0966-842X(00)01843-6
Antigen 85 Isoforms Have Unique Substrates and Activities Determined by Non-active Site Regions, Journal of Biological Chemistry, vol.1473, issue.36, pp.25041-25053, 2014. ,
DOI : 10.1128/AAC.16.2.240
URL : http://www.jbc.org/content/289/36/25041.full.pdf
ABSTRACT, Antimicrobial Agents and Chemotherapy, vol.56, issue.4, pp.1735-174305742, 2012. ,
DOI : 10.1128/AAC.05742-11
A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebraf ish embr yos. Molecular Microbiolog y 80, pp.919-934, 2011. ,
Synthetic Lethality Reveals Mechanisms of Mycobacterium tuberculosis Resistance to ??-Lactams, mBio, vol.5, issue.5, pp.1767-1781, 1767. ,
DOI : 10.1128/mBio.01767-14
From The Cover: Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages, Proceedings of the National Academy of Sciences, pp.8327-83320503272102, 2005. ,
DOI : 10.1016/j.tim.2004.10.005
Mycobacterium tuberculosis Rv2224c modulates innate immune responses, Proceedings of the National Academy of Sciences, vol.98, issue.22, pp.264-2690710601105, 2008. ,
DOI : 10.1073/pnas.231275498
URL : http://www.pnas.org/content/105/1/264.full.pdf
Characterization of a Carbon-Carbon Hydrolase from Mycobacterium tuberculosis Involved in Cholesterol Metabolism, Journal of Biological Chemistry, vol.255, issue.1, pp.434-443058081, 2010. ,
DOI : 10.1016/j.jmb.2006.11.016
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach, British Journal of Pharmacology, vol.5, issue.14, pp.2209-2224, 2017. ,
DOI : 10.1371/journal.ppat.1000344
LigPlot+: Multiple Ligand???Protein Interaction Diagrams for Drug Discovery, Journal of Chemical Information and Modeling, vol.51, issue.10, pp.2778-2786, 2011. ,
DOI : 10.1021/ci200227u
A Novel Lipase Belonging to the Hormone-sensitive Lipase Family Induced under Starvation to Utilize Stored Triacylglycerol in Mycobacterium tuberculosis, Journal of Biological Chemistry, vol.281, issue.7, pp.3866-3875, 2006. ,
DOI : 10.1074/jbc.M505556200
Mycobacterial lipolytic enzymes: A gold mine for tuberculosis research, Biochimie, vol.95, issue.1, pp.66-73, 2013. ,
DOI : 10.1016/j.biochi.2012.07.008
The ??/?? Hydrolase Fold Proteins of Mycobacterium tuberculosis, with Reference to their Contribution to Virulence, Current Protein & Peptide Science, vol.18, issue.3, pp.190-2101389203717666160729093515, 2017. ,
DOI : 10.2174/1389203717666160729093515
Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence, PLoS Pathogens, vol.39, issue.11, 2008. ,
DOI : 10.1371/journal.ppat.1000204.s002
Triacylglycerol Utilization Is Required for Regrowth of In Vitro Hypoxic Nonreplicating Mycobacterium bovis Bacillus Calmette-Guerin, Journal of Bacteriology, vol.191, issue.16, pp.5037-504300530, 2009. ,
DOI : 10.1128/JB.00530-09
MmPPOX Inhibits Mycobacterium tuberculosis Lipolytic Enzymes Belonging to the Hormone-Sensitive Lipase Family and Alters Mycobacterial Growth, PLoS ONE, vol.7, issue.9, 2012. ,
DOI : 10.1371/journal.pone.0046493.s004
ABSTRACT, Antimicrobial Agents and Chemotherapy, vol.60, issue.10, pp.6193-619900872, 2016. ,
DOI : 10.1128/AAC.00872-16
Phosphonates as analogues of natural phosphates, Chemical Reviews, vol.77, issue.3, pp.349-367, 1977. ,
DOI : 10.1021/cr60307a003
Mycobacterium tuberculosis ??RD1 ??panCD: A safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis, Vaccine, vol.24, issue.37-39, pp.6309-6320, 2006. ,
DOI : 10.1016/j.vaccine.2006.05.097
Electrophoresis of Mycobacteria. Mycobacteria protocols, pp.117-130, 2015. ,
The M. tuberculosis antigen 85 complex and mycolyltransferase activity, Letters in Applied Microbiology, vol.68, issue.4, pp.233-237, 2002. ,
DOI : 10.1038/72413
Resazurin Microtiter Assay Plate: Simple and Inexpensive Method for Detection of Drug Resistance in Mycobacterium tuberculosis, Antimicrobial Agents and Chemotherapy, vol.46, issue.8, pp.2720-2722, 2002. ,
DOI : 10.1128/AAC.46.8.2720-2722.2002
Resazurin Microtiter Assay Plate Testing of Mycobacterium tuberculosis Susceptibilities to Second-Line Drugs: Rapid, Simple, and Inexpensive Method, Antimicrobial Agents and Chemotherapy, vol.47, issue.11, pp.3616-3619, 2003. ,
DOI : 10.1128/AAC.47.11.3616-3619.2003
A Simple and Cost Efficient Method to Avoid Unequal Evaporation in Cellular Screening Assays, Which Restores Cellular Metabolic Activity, Int. J. Appl. Sci. Technol, vol.2, pp.17-21, 2012. ,
Bénarouche post-doctoral fellowship was supported by an ATER position from Aix-Marseille University. A. Madani was supported by a PhD fellowship from the Association Grégory Lemarchal and Vaincre la Mucoviscidose (projet n°RF20160501651). Dr, is acknowledged for providing M. tb mc 2 6230 and Kris Huygen for providing the Ag85 monoclonal antibody ,