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, The homology model was then compared to the 3D structure of ZIKV NS5MTase once it was released, showing full similarity, When the work was carried out, the 3D structure of ZIKV NS5-MTase was not elucidated yet. Thus, a homology model based on the DENV NS5 MTase was built
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, Compound 15 did not show any effect on DENV MTase and poorly inhibited the ZIKV MTase (25 % of inhibition). For this reason, the IC 50 of 15 against ZIKV MTase was not determined, 2019.