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Journal Articles Antimicrobial Agents and Chemotherapy Year : 2008

Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae.

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Abstract

Fluoroquinolone resistance in Streptococcus pneumoniae mainly involves stepwise mutations predominantly in the parC and gyrA genes. We have developed a single-run real-time PCR assay for detection of the four most common mutations in the quinolone resistance-determining regions of these genes. This assay provides a useful tool for both clinical and epidemiological use.

Dates and versions

pasteur-00451015 , version 1 (27-01-2010)

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S. Page, F. Vernel-Pauillac, O. O'Connor, S. Bremont, F. Charavay, et al.. Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae.. Antimicrobial Agents and Chemotherapy, 2008, 52 (11), pp.4155-8. ⟨10.1128/AAC.00082-08⟩. ⟨pasteur-00451015⟩
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