Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae.

S. Page 1 F. Vernel-Pauillac 1 O. O'Connor 1 S. Bremont 2 F. Charavay 1 P. Courvalin 2 C. Goarant 1 S. Le Hello 1, 2
1 Institut Pasteur de Nouvelle-Calédonie
2 Agents antibactériens
Abstract : Fluoroquinolone resistance in Streptococcus pneumoniae mainly involves stepwise mutations predominantly in the parC and gyrA genes. We have developed a single-run real-time PCR assay for detection of the four most common mutations in the quinolone resistance-determining regions of these genes. This assay provides a useful tool for both clinical and epidemiological use.
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Journal articles
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https://hal-riip.archives-ouvertes.fr/pasteur-00451015
Contributor : Cyrille Goarant <>
Submitted on : Wednesday, January 27, 2010 - 11:10:27 PM
Last modification on : Monday, January 13, 2020 - 5:08:05 PM

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PASTEUR | RIIP | RIIP_NOUVELLECALEDONIE

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S. Page, F. Vernel-Pauillac, O. O'Connor, S. Bremont, F. Charavay, et al.. Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2008, 52 (11), pp.4155-8. ⟨10.1128/AAC.00082-08⟩. ⟨pasteur-00451015⟩

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