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Article Dans Une Revue Frontiers in bioscience : a journal and virtual library Année : 2007

Towards a quantitative perception of human-microbial co-evolution.

Résumé

The influence of changes in population structures of modern humans and human pathogens is likely reciprocal. In my opinion, a quantitative approach to study this co-influence in a historical perspective requires, in particular, adequate estimators of genetic distances that are well developed for human but not yet for microbial populations. Here, I propose a simple measure of genetic distance between geographic populations within a microbial species based on the observed difference in the frequencies of its genotypes. Further, I apply the proposed method to principal components analysis of Mycobacterium tuberculosis, and interpret the geographic distribution of its VNTR haplotypes in the light of human historical and recent migrations. The proposed approach may be helpful for a quantitative understanding of human-microbial interactions that constitute an integral part of the global history.

Domaines

Biodiversité

Dates et versions

pasteur-00499539 , version 1 (09-07-2010)

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Citer

Igor Mokrousov. Towards a quantitative perception of human-microbial co-evolution.. Frontiers in bioscience : a journal and virtual library, 2007, 12, pp.4818-25. ⟨10.2741/2430⟩. ⟨pasteur-00499539⟩
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