Multidrug-resistant Mycobacterium tuberculosis strain from Equatorial Guinea detected in Spain.

Patricia Gavín 1, * Maria J Iglesias Maria S Jiménez Laura Herrera-Leon Elena Rodríguez-Valín Nalin Rastogi 2 Josefa March Rosa González-Palacios Elia Palenque Rafael Ayarza Elena Hurra Isolina Campos-Herrero María A Vitoria María A Lezcano María J Revillo Carlos Martin Sofía Samper 1, 3
* Corresponding author
1 Instituto Aragones de Ciencias de la Salud [Zaragoza, Spain]
2 Institut Pasteur de la Guadeloupe
3 Hospital Universitario Miguel Servet
Abstract : This investigation focused on a specific Multidrug-Resistant (MDR) Mycobacterium tuberculosis strain from Equatorial Guinea that had been imported into Spain. Ten MDR isolates from as many patients from Equatorial Guinea were detected in Spain during 2000 through 2008. All the 10 isolates exhibited an identical genotypic pattern belonging to the Latin-American and Mediterranean (LAM) genotypic lineage of M. tuberculosis designated SIT177-LAM 9. Evidence of clonality was found for all the 10 isolates by different molecular epidemiology methods and mutations involved in drug resistance. The analysis of the RDRio deletion confirmed that the strain belonged to the major RDRio sublineage of the Latin-American and Mediterranean (LAM) genotypic lineage of M. tuberculosis which has disseminated globally.
Keywords : "Equatorial Guinea" "Spain" "Multidrug-Resistant" "Epidemiology" "Immigrants" "Spoligotyping" "MIRU-VNTR" "IS6110-RFLP" "SITVIT2" "Tuberculosis" "Mycobacterium" SITVIT2 IS6110-RFLP MIRU-VNTR Spoligotyping Immigrants Epidemiology Multidrug-Resistant Spain Equatorial Guinea Tuberculosis Mycobacterium
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Patricia Gavín, Maria J Iglesias, Maria S Jiménez, Laura Herrera-Leon, Elena Rodríguez-Valín, et al.. Multidrug-resistant Mycobacterium tuberculosis strain from Equatorial Guinea detected in Spain.. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2009, 15 (11), pp.1858-1860. ⟨10.3201/eid1511.090449⟩. ⟨pasteur-00511967⟩

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