Multidrug-resistant Mycobacterium tuberculosis strain from Equatorial Guinea detected in Spain.

Patricia Gavín (1) , Maria J Iglesias , Maria S Jiménez , Laura Herrera-Leon , Elena Rodríguez-Valín , Nalin Rastogi (2) , Josefa March , Rosa González-Palacios , Elia Palenque , Rafael Ayarza , Elena Hurra , Isolina Campos-Herrero , María A Vitoria , María A Lezcano , María J Revillo , Carlos Martin , Sofía Samper (1, 3)

1 IACS - Instituto Aragonés de Ciencias de la Salud [Zaragoza]
2 Institut Pasteur de la Guadeloupe
3 Hospital Universitario Miguel Servet

This investigation focused on a specific Multidrug-Resistant (MDR) Mycobacterium tuberculosis strain from Equatorial Guinea that had been imported into Spain. Ten MDR isolates from as many patients from Equatorial Guinea were detected in Spain during 2000 through 2008. All the 10 isolates exhibited an identical genotypic pattern belonging to the Latin-American and Mediterranean (LAM) genotypic lineage of M. tuberculosis designated SIT177-LAM 9. Evidence of clonality was found for all the 10 isolates by different molecular epidemiology methods and mutations involved in drug resistance. The analysis of the RDRio deletion confirmed that the strain belonged to the major RDRio sublineage of the Latin-American and Mediterranean (LAM) genotypic lineage of M. tuberculosis which has disseminated globally.

Keywords: Mycobacterium; Tuberculosis; Equatorial Guinea; Spain; Multidrug-Resistant; Epidemiology; Immigrants; Spoligotyping; MIRU-VNTR; IS6110-RFLP; SITVIT2; "Mycobacterium"; "Tuberculosis"; "Equatorial Guinea"; "Spain"; "Multidrug-Resistant"; "Epidemiology"; "Immigrants"; "Spoligotyping"; "MIRU-VNTR"; "IS6110-RFLP"; "SITVIT2"

Domains: Bacteriology

Patricia Gavín, Maria J Iglesias, Maria S Jiménez, Laura Herrera-Leon, Elena Rodríguez-Valín, et al.. Multidrug-resistant Mycobacterium tuberculosis strain from Equatorial Guinea detected in Spain.. Emerging Infectious Diseases, 2009, 15 (11), pp.1858-1860. ⟨10.3201/eid1511.090449⟩. ⟨pasteur-00511967⟩