S. Samper, M. Iglesias, M. Rabanaque, L. Gómez, M. Lafoz et al., Systematic Molecular Characterization of Multidrug-Resistant Mycobacterium tuberculosis Complex Isolates from Spain, Journal of Clinical Microbiology, vol.43, issue.3, pp.1220-1227, 2005.
DOI : 10.1128/JCM.43.3.1220-1227.2005

J. Kamerbeek, L. Schouls, A. Kolk, M. Van-agterveld, D. Van-soolingen et al., Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology, J Clin Microbiol, vol.35, pp.907-921, 1997.

P. Supply, C. Allix, S. Lesjean, M. Cardoso-oelemann, S. Rüsch-gerdes et al., Proposal for Standardization of Optimized Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat Typing of Mycobacterium tuberculosis, Journal of Clinical Microbiology, vol.44, issue.12, pp.4498-51001392, 2006.
DOI : 10.1128/JCM.01392-06

K. Brudey, J. Driscoll, L. Rigouts, W. Prodinger, A. Gori et al., Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (Spol- DB4) for classifi cation, population genetics and epidemiology, BMC Microbiology, vol.6, issue.1, pp.23-33, 2006.
DOI : 10.1186/1471-2180-6-23

G. Tudó, J. González, R. Obama, J. Rodríguez, J. Franco et al., Study of resistance to anti-tuberculosis drugs in fi ve districts of Equatorial Guinea: rates, risk factors, genotyping of gene mutations and molecular epidemiology, Int J Tuberc Lung Dis, vol.8, pp.15-22, 2004.

L. Herrera-león, T. Molina, P. Saíz, J. Sáez-nieto, and M. Jiménez, New Multiplex PCR for Rapid Detection of Isoniazid-Resistant Mycobacterium tuberculosis Clinical Isolates, Antimicrobial Agents and Chemotherapy, vol.49, issue.1, pp.144-151, 2005.
DOI : 10.1128/AAC.49.1.144-147.2005

S. Sreevatsan, X. Pan, K. Stockbauer, N. Connell, B. Kreiswirth et al., Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination, Proceedings of the National Academy of Sciences, vol.94, issue.18, pp.9869-74, 1997.
DOI : 10.1073/pnas.94.18.9869

S. Gagneux, K. Deriemer, T. Van, M. Kato-maeda, B. De-jong et al., Variable host-pathogen compatibility in Mycobacterium tuberculosis, Proceedings of the National Academy of Sciences, vol.103, issue.8, pp.2869-73, 2006.
DOI : 10.1073/pnas.0511240103

L. Lazzarini, R. Huard, N. Boechat, H. Gomes, M. Oelemann et al., Discovery of a Novel Mycobacterium tuberculosis Lineage That Is a Major Cause of Tuberculosis in Rio de Janeiro, Brazil, Journal of Clinical Microbiology, vol.45, issue.12, pp.3891-90201394, 2007.
DOI : 10.1128/JCM.01394-07

P. Address and . Gavín, Consultas Externas Planta 4ª, Hospital Universitario Miguel Servet, Calle Cardenal Gomá sn, Laboratorio de Investigación Molecular Zaragoza, vol.50009