Island biogeography reveals the deep history of SIV.

Michael Worobey (1) , Paul Telfer (2, 3) , Sandrine Souquière (2) , Meredith Hunter (3) , Clint A Coleman (3) , Michael J Metzger (3) , Patricia Reed (2, 3) , Maria Makuwa (2) , Gail Hearn (4) , Shaya Honarvar (4) , Pierre Roques (2) , Cristian Apetrei (3) , Mirdad Kazanji (2, 5) , Preston A Marx

1 University of Arizona
2 CIRMF - Centre International de Recherches Médicales de Franceville
3 Tulane National Primate Research Center
4 College of Information Science & Technology
5 IP - Institut Pasteur [Paris]

Simian immunodeficiency virus (SIV) lineages have been identified that are endemic to Bioko Island. The time the island formed offers a geological time scale calibration point for dating the most recent common ancestor of SIV. The Bioko viruses cover the whole range of SIV genetic diversity, and each Bioko SIV clade is most closely related to viruses circulating in hosts of the same genus on the African mainland rather than to SIVs of other Bioko species. Our phylogeographic approach establishes that SIV is ancient and at least 32,000 years old. Our conservative calibration point and analyses of gene sequence saturation and dating bias suggest it may be much older.

Domaines: Autre [q-bio.OT]

Michael Worobey, Paul Telfer, Sandrine Souquière, Meredith Hunter, Clint A Coleman, et al.. Island biogeography reveals the deep history of SIV.. Science, 2010, 329 (5998), pp.1487. ⟨10.1126/science.1193550⟩. ⟨pasteur-00540189⟩