First Data on HIV-1 Resistance Mutations to Antiretroviral Drugs in Central African Republic.

Sandrine Moussa (1) , Patricia Pinson (2) , Pulchérie Pelembi (1) , Jean-Chrysostome Gody (3) , Olivia Mbitikon (3) , Valentin Fikouma (4) , Paulette Mbay (4) , Hervé J Fleury (2)

1 Institut Pasteur de Bangui
2 Variabilité génomique des virus
3 Complexe pédiatrique
4 CTA/CRF - Hopital Communautaire

Abstract In a background of high genomic HIV-1 variability with a predominance of CRF11_cpx and CRF22_01A1, we have studied the emergence of resistance mutations in isolates from Central African patients at failure of d4T-AZT/3TC/NVP-EFV plus two at failure of a PI-including regimen; the resistance mutations observed are those which are expected on HIV-1 subtype B.

Domains: Life Sciences [q-bio]; Other [q-bio.OT]

Sandrine Moussa, Patricia Pinson, Pulchérie Pelembi, Jean-Chrysostome Gody, Olivia Mbitikon, et al.. First Data on HIV-1 Resistance Mutations to Antiretroviral Drugs in Central African Republic.. AIDS Research and Human Retroviruses, 2010, 26 (11), pp.1247-8. ⟨10.1089/aid.2010.0091⟩. ⟨pasteur-00540395⟩