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Rapid identification of multidrug-resistant tuberculosis isolates in treatment failure or relapse patients in Bangui, Central African Republic.

Abstract : Multidrug-resistant (MDR) strains were identified in 40% of 54 strains from patients presenting with tuberculosis (TB) treatment failure or relapse in Bangui, Central African Republic. Results obtained with the MTBDRplus line-probe assay or rpoB sequencing were 86% concordant with rifampicin (RMP) resistant phenotypes, while the amplification refractory mutation system test was 71% concordant. No mutation was found in RMP-susceptible strains. MTBDRplus and sequencing were concordant with the detection of the S315T mutation in katG in 95% of MDR strains. Sequencing of pncA suggested pyrazinamide resistance in 50% of MDR strains. Knowledge of these resistances should help to implement treatment in low-income countries.
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https://hal-riip.archives-ouvertes.fr/pasteur-00540451
Contributor : Mirdad Kazanji Connect in order to contact the contributor
Submitted on : Friday, November 26, 2010 - 4:59:17 PM
Last modification on : Thursday, April 7, 2022 - 10:10:18 AM

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  • HAL Id : pasteur-00540451, version 1
  • PUBMED : 20487620

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F. Minime-Lingoupou, C. Pierre-Audigier, E. Kassa-Kélémbho, N. Barilone, G. Zandanga, et al.. Rapid identification of multidrug-resistant tuberculosis isolates in treatment failure or relapse patients in Bangui, Central African Republic.. International Journal of Tuberculosis and Lung Disease, 2010, 14 (6), pp.782-5. ⟨pasteur-00540451⟩

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