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Rapid identification of multidrug-resistant tuberculosis isolates in treatment failure or relapse patients in Bangui, Central African Republic.

Abstract : Multidrug-resistant (MDR) strains were identified in 40% of 54 strains from patients presenting with tuberculosis (TB) treatment failure or relapse in Bangui, Central African Republic. Results obtained with the MTBDRplus line-probe assay or rpoB sequencing were 86% concordant with rifampicin (RMP) resistant phenotypes, while the amplification refractory mutation system test was 71% concordant. No mutation was found in RMP-susceptible strains. MTBDRplus and sequencing were concordant with the detection of the S315T mutation in katG in 95% of MDR strains. Sequencing of pncA suggested pyrazinamide resistance in 50% of MDR strains. Knowledge of these resistances should help to implement treatment in low-income countries.
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https://hal-riip.archives-ouvertes.fr/pasteur-00540451
Contributor : Mirdad Kazanji <>
Submitted on : Friday, November 26, 2010 - 4:59:17 PM
Last modification on : Monday, January 13, 2020 - 5:08:06 PM

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  • HAL Id : pasteur-00540451, version 1
  • PUBMED : 20487620

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F. Minime-Lingoupou, C. Pierre-Audigier, E. Kassa-Kélémbho, N. Barilone, G. Zandanga, et al.. Rapid identification of multidrug-resistant tuberculosis isolates in treatment failure or relapse patients in Bangui, Central African Republic.. International Journal of Tuberculosis and Lung Disease, International Union Against Tuberculosis and Lung Disease, 2010, 14 (6), pp.782-5. ⟨pasteur-00540451⟩

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