A fatal case of acute hepatitis E among pregnant women, Central African Republic.

Abstract : ABSTRACT: BACKGROUND: Hepatitis E virus (HEV) is a major public health problem in developing countries. HEV infection in pregnant women is more common and more often fatal in the third trimester. The mortality rate due to HEV-induced hepatitis is as high as 15-20 per cent. The present study was designed to determine the potential factors responsible for high mortality rate among pregnant women. FINDINGS: Twenty one pregnant women attended the Maternity Center of Begoua in the Central African Republic during an outbreak of hepatitis E virus between July and October 2002 with symptoms of acute liver disease. Their mean gestational period was 29.9 (SD 8.3 weeks) and they were aged from 15 to 39 years old. The serology IgM showed that seven women (33%) had acute hepatitis E. Among them, one woman, aged 35 and her newborn died after an apparently normal preterm delivery. The 6 remaining young women, age 18 - 22, had preterm deliveries which included three live babies and three stillborn with one macerated. CONCLUSIONS: These results suggest that maternal age, in addition to hormonal, immunological and environmental factors, may be a risk factor for fatal outcome.
Document type :
Journal articles
Complete list of metadatas

Cited literature [13 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-00540462
Contributor : Mirdad Kazanji <>
Submitted on : Friday, November 26, 2010 - 5:06:53 PM
Last modification on : Monday, October 8, 2018 - 5:44:05 PM
Long-term archiving on: Sunday, February 27, 2011 - 3:01:13 AM

File

Goumba_et_al.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Charles M. Goumba, Emmanuel R. Yandoko-Nakouné, Narcisse P Komas. A fatal case of acute hepatitis E among pregnant women, Central African Republic.. BMC Research Notes, BioMed Central, 2010, 3, pp.103. ⟨10.1186/1756-0500-3-103⟩. ⟨pasteur-00540462⟩

Share

Metrics

Record views

233

Files downloads

180