J. Schulman and E. Kilbourne, Induction of partial specific heterotypic immunity in mice by a single infection with influenza a virus, J Bacteriol, vol.89, pp.170-174, 1965.

R. Yetter, W. Barber, and P. Small, Heterosubtypic immunity to influenza in ferrets, Infect Immun, vol.29, pp.650-653, 1980.

P. Heinen, E. De-boer-luijtze, and A. Bianchi, Respiratory and systemic humoral and cellular immune responses of pigs to a heterosubtypic influenza A virus infection, Journal of General Virology, vol.82, issue.11, pp.2697-2707, 2001.
DOI : 10.1099/0022-1317-82-11-2697

S. Seo and R. Webster, Cross-Reactive, Cell-Mediated Immunity and Protection of Chickens from Lethal H5N1 Influenza Virus Infection in Hong Kong Poultry Markets, Journal of Virology, vol.75, issue.6, pp.2516-2525, 2001.
DOI : 10.1128/JVI.75.6.2516-2525.2001

S. Epstein, Control of influenza virus infection by immunity to conserved viral features, Expert Review of Anti-infective Therapy, vol.1, issue.4, pp.627-638, 2003.
DOI : 10.1586/14787210.1.4.627

T. Ichinohe, S. Tamura, A. Kawaguchi, A. Ninomiya, and M. Imai, Cross???Protection against H5N1 Influenza Virus Infection Is Afforded by Intranasal Inoculation with Seasonal Trivalent Inactivated Influenza Vaccine, The Journal of Infectious Diseases, vol.196, issue.9, pp.1313-1320, 2007.
DOI : 10.1086/521304

A. Slepushkin, The effect of a previous attack of A1 influenza on susceptibility to A2 virus during the 1957 outbreak, Bull Word Health Organ, vol.20, pp.297-301, 1959.

S. Epstein, Prior H1N1 Influenza Infection and Susceptibility of Cleveland Family Study Participants during the H2N2 Pandemic of 1957: An Experiment of Nature, The Journal of Infectious Diseases, vol.193, issue.1, pp.49-53, 2006.
DOI : 10.1086/498980

K. Grebe, J. Yewdell, and J. Bennink, Heterosubtypic immunity to influenza A virus: where do we stand?, Microbes and Infection, vol.10, issue.9, pp.1024-1029, 2008.
DOI : 10.1016/j.micinf.2008.07.002

M. Sandbulte, G. Jimenez, A. Boon, L. Smith, and J. Treanor, Cross-Reactive Neuraminidase Antibodies Afford Partial Protection against H5N1 in Mice and Are Present in Unexposed Humans, PLoS Medicine, vol.41, issue.2, 2007.
DOI : 10.1371/journal.pmed.0040059.g005

I. Stephenson, K. Nicholson, R. Glück, R. Mischler, and R. Newman, Safety and antigenicity of whole virus and subunit influenza A/Hong Kong/1073/99 (H9N2) vaccine in healthy adults: phase I randomised trial, The Lancet, vol.362, issue.9400, pp.1959-1966, 2003.
DOI : 10.1016/S0140-6736(03)15014-3

J. Treanor, J. Campbell, K. Zangwill, T. Rowe, and M. Wolff, Safety and Immunogenicity of an Inactivated Subvirion Influenza A (H5N1) Vaccine, New England Journal of Medicine, vol.354, issue.13, pp.1343-1351, 2006.
DOI : 10.1056/NEJMoa055778

M. Throsby, E. Van-den-brink, M. Jongeneelen, L. Poon, and P. Alard, Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells, PLoS ONE, vol.81, issue.12, 2008.
DOI : 10.1371/journal.pone.0003942.s001

D. Ekiert, G. Bhabha, M. Elsliger, R. Friesen, and M. Jongeneelen, Antibody Recognition of a Highly Conserved Influenza Virus Epitope, Science, vol.324, issue.5924, 2009.
DOI : 10.1126/science.1171491

J. Sui, W. Hwang, S. Perez, G. Wei, and D. Aird, Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses, Nature Structural & Molecular Biology, vol.371, issue.3, pp.265-273, 2009.
DOI : 10.1038/nsmb.1566

J. Garcia, K. Fries, N. Lagarde, E. Ma, and P. Buchy, Optimization and evaluation of an influenza A (H5) pseudotyped lentiviral particle-based serological assay, Journal of Clinical Virology, vol.47, issue.1
DOI : 10.1016/j.jcv.2009.10.009

URL : https://hal.archives-ouvertes.fr/pasteur-00561333

S. Chiu, J. Peiris, K. Chan, W. Wong, and Y. Lau, Immunogenicity and Safety of Intradermal Influenza Immunization at a Reduced Dose in Healthy Children, PEDIATRICS, vol.119, issue.6, pp.1076-1082, 2007.
DOI : 10.1542/peds.2006-3176

URL : https://hal.archives-ouvertes.fr/pasteur-00589024

S. Hui, L. Chu, J. Peiris, K. Chan, and D. Chu, Immune response to influenza vaccination in community-dwelling Chinese elderly persons, Vaccine, vol.24, issue.25, pp.5371-5380, 2006.
DOI : 10.1016/j.vaccine.2006.04.032

I. Nefkens, J. Garcia, N. Lagarde, K. Chu, and M. Peiris, Hemagglutinin pseudotyped lentiviral particles: Characterization of a new method for avian H5N1 influenza sero-diagnosis, Journal of Clinical Virology, vol.39, issue.1, pp.27-33, 2007.
DOI : 10.1016/j.jcv.2007.02.005

URL : https://hal.archives-ouvertes.fr/pasteur-00589029

A. Hill, The possible effects of aggregation of the molecules of hemoglobin on its dissociation curves, J Physiol (Lond.), vol.40, pp.4-7, 1910.

Y. Choi, T. Nguyen, H. Ozaki, R. Webby, and P. Puthavathana, Studies of H5N1 Influenza Virus Infection of Pigs by Using Viruses Isolated in Vietnam and Thailand in 2004, Journal of Virology, vol.79, issue.16, pp.10821-10825, 2005.
DOI : 10.1128/JVI.79.16.10821-10825.2005

J. Bresson, C. Perronne, O. Launay, C. Gerdil, and M. Saville, Safety and immunogenicity of an inactivated split-virion influenza A/VietnamH5N1) vaccine: phase I randomised trial, Lancet, vol.1194, issue.367, pp.1657-1664, 2004.

K. Levie, I. Leroux-roels, K. Hoppenbrouwers, A. Kervyn, and C. Vandermeulen, An Adjuvanted, Low???Dose, Pandemic Influenza A (H5N1) Vaccine Candidate Is Safe, Immunogenic, and Induces Cross???Reactive Immune Responses in Healthy Adults, The Journal of Infectious Diseases, vol.198, issue.5, pp.642-649, 2008.
DOI : 10.1086/590913

J. Katz, W. Lim, C. Bridges, T. Rowe, and J. Hu-primmer, Antibody Response in Individuals Infected with Avian Influenza A (H5N1) Viruses and Detection of Anti???H5 Antibody among Household and Social Contacts, The Journal of Infectious Diseases, vol.180, issue.6, pp.1763-1770, 1999.
DOI : 10.1086/315137

D. Laddy, J. Yan, M. Kutzler, D. Kobasa, and G. Kobinger, Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens, PLoS ONE, vol.80, issue.6, 2008.
DOI : 10.1371/journal.pone.0002517.t002

S. Khurana, A. Suguitan, . Jr, Y. Rivera, C. Simmons et al., Antigenic Fingerprinting of H5N1 Avian Influenza Using Convalescent Sera and Monoclonal Antibodies Reveals Potential Vaccine and Diagnostic Targets, PLoS Medicine, vol.80, issue.1, 2009.
DOI : 10.1371/journal.pmed.1000049.s006

R. Yoshida, M. Igarashi, H. Ozaki, N. Kishida, and D. Tomabechi, Crossprotective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses, Plos Pathogens, vol.5, 2009.

T. Wang and P. Palese, Universal epitopes of influenza virus hemagglutinins?, Nature Structural & Molecular Biology, vol.7, issue.3, pp.233-234, 2009.
DOI : 10.1038/nsmb.1574

A. Kashyap, J. Steel, A. Oner, M. Dillon, and R. Swale, Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies, Proceedings of the National Academy of Sciences, vol.105, issue.16, pp.5986-5991, 2008.
DOI : 10.1073/pnas.0801367105

S. Vong, B. Coghlan, M. Sek, D. Holl, and H. Seng, Low Frequency of Poultry-to-Human H5N1 Transmission, Southern Cambodia, 2005, Emerging Infectious Diseases, vol.12, issue.10, pp.1542-1547, 2005.
DOI : 10.3201/eid1210.060424

A. Abdel-ghafar, T. Chotpitayasunondh, Z. Gao, F. Hayden, and D. Nguyen, Update on avian influenza A (H5N1) virus infection in humans, WHO. Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian Influenza A (H5N1) Virus, pp.261-273, 2008.