Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Plasmodium vivax and the Duffy antigen: a paradigm revisited.

Abstract : The Duffy blood group antigen is the portal of entry of the Plasmodiumvivax malaria parasite into human red blood cells and the receptor for a number of CXC and CC chemokines. We review here epidemiological data and evidence derived from therapeutic or experimental human infections associating P. vivax and the Duffy glycoprotein and laboratory studies indicating that P. vivax uses the Duffy antigen as a receptor to invade the red cell. We then review recent field observations indicating that the conclusion of the absolute dependence on the presence of Duffy on the red cell for P. vivax infection and development into the red cell no longer holds true and that in some parts of the world, P. vivax infects and causes disease in Duffy-negative people.
Document type :
Journal articles
Complete list of metadata

Cited literature [61 references]  Display  Hide  Download
Contributor : Didier Menard Connect in order to contact the contributor
Submitted on : Tuesday, January 18, 2011 - 12:41:52 PM
Last modification on : Thursday, April 7, 2022 - 10:10:20 AM
Long-term archiving on: : Friday, December 2, 2016 - 6:20:55 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




O. Mercereau-Puijalon, D. Ménard. Plasmodium vivax and the Duffy antigen: a paradigm revisited.. Transfusion Clinique et Biologique, Elsevier, 2010, 17 (3), pp.176-83. ⟨10.1016/j.tracli.2010.06.005⟩. ⟨pasteur-00557028⟩



Record views