Heritability of the human infectious reservoir of malaria parasites.

Yaye Ramatoulaye Lawaly (1) , Anavaj Sakuntabhai (2, 3) , Laurence Marrama (1) , Lassana Konate (4) , Waraphon Phimpraphi (2, 5) , Cheikh Sokhna (6) , Adama Tall (1) , Fatoumata Diène Sarr (1) , Chayanon Peerapittayamongkol (2) , Chalisa Louicharoen (2, 7) , Bradley S Schneider (3) , Anaïs Levescot (2) , Arthur Talman (8) , Isabelle Casademont (2, 3) , Didier Menard (8, 9) , Jean-François Trape (6) , Christophe Rogier (10) , Jaranit Kaewkunwal (5) , Thanyachai Sura (11) , Issarang Nuchprayoon , Frederic Ariey (8) , Laurence Baril (1) , Pratap Singhasivanon (12) , Odile Mercereau-Puijalon (13) , Rick Paul (1, 2, 3)

1 Institut Pasteur de Dakar
2 Génétique de la Réponse aux Infections chez l'Homme
3 Pathogénie Virale Moléculaire
4 Faculté des Sciences et Techniques Dakar
5 Department of Tropical Hygiene
6 Paludologie afrotropicale
7 Graduate School [Bangkok, Thailande]
8 Institut Pasteur du Cambodge
9 Institut Pasteur de Madagascar
10 Unité de Recherche en Biologie et Epidémiologie Parasitaires
11 Department of Medicine
12 Department of Pediatrics
13 Virulence Parasitaire

The existence of a significant human genetic contribution to gametocyte prevalence in asymptomatic infections suggests that candidate gene and genome wide association approaches may be usefully applied to explore the underlying human genetics. Prospective epidemiological studies will provide an opportunity to generate novel and perhaps more epidemiologically pertinent gametocyte data with which similar analyses can be performed and the role of human genetics in parasite transmission ascertained.

Domains: Life Sciences [q-bio]; Microbiology and Parasitology

Yaye Ramatoulaye Lawaly, Anavaj Sakuntabhai, Laurence Marrama, Lassana Konate, Waraphon Phimpraphi, et al.. Heritability of the human infectious reservoir of malaria parasites.. PLoS ONE, 2010, 5 (6), pp.e11358. ⟨10.1371/journal.pone.0011358⟩. ⟨pasteur-00557029⟩