R. Carter and L. Miller, Evidence for environmental modulation of gametocytogenesis in Plasmodium falciparum in continuous culture, Bull World Health Organ, vol.57, pp.37-52, 1979.

R. Sinden, G. Butcher, O. Billker, and S. Fleck, Regulation of Infectivity of Plasmodium to the Mosquito Vector, Adv Parasitol, vol.38, pp.53-117, 1996.
DOI : 10.1016/S0065-308X(08)60033-0

A. Buckling, L. Ranford-cartwright, A. Miles, and A. Read, Chloroquine increases Plasmodium falciparum gametocytogenesis in vitro, Parasitology, vol.118, issue.4, pp.339-346, 1999.
DOI : 10.1017/S0031182099003960

E. Ali, M. Mackinnon, A. Abdel-muhsin, S. Ahmed, and D. Walliker, Increased density but not prevalence of gametocytes following drug treatment of Plasmodium falciparum, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.100, issue.2, pp.176-183, 2006.
DOI : 10.1016/j.trstmh.2005.04.021

W. Trager and G. Gill, In Vitro, The Journal of Protozoology, vol.69, issue.Suppl. 1, pp.429-432, 1992.
DOI : 10.1111/j.1550-7408.1992.tb01476.x

R. Price, F. Nosten, J. Simpson, C. Luxemburger, and L. Phaipun, Risk factors for gametocyte carriage in uncomplicated falciparum malaria, Am J Trop Med Hyg, vol.60, pp.1019-1023, 1999.

M. Nacher, P. Singhasivanon, U. Silachamroon, S. Treeprasertsuk, and T. Tosukhowong, Decreased Hemoglobin Concentrations, Hyperparasitemia, and Severe Malaria Are Associated with Increased Plasmodium falciparum Gametocyte Carriage, The Journal of Parasitology, vol.88, issue.1, pp.97-101, 2002.
DOI : 10.2307/3285398

A. Githeko, A. Brandling-bennett, M. Beier, F. Atieli, and M. Owaga, The reservoir of Plasmodium falciparum malaria in a holoendemic area of western Kenya, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.86, issue.4, pp.355-358, 1992.
DOI : 10.1016/0035-9203(92)90216-Y

C. Boudin, M. Olivier, J. Molez, J. Chiron, and P. Ambroise-thomas, High human malarial infectivity to laboratory-bred Anopheles gambiae in a village in Burkina Faso, Am J Trop Med Hyg, vol.48, pp.700-706, 1993.

S. Bonnet, C. Gouagna, R. Paul, I. Safeukui, and J. Meunier, Estimation of malaria transmission from humans to mosquitoes in two neighbouring villages in south Cameroon: evaluation and comparison of several indices, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.97, issue.1, pp.53-59, 2003.
DOI : 10.1016/S0035-9203(03)90022-8

A. Abdel-wahab, A. Abdel-muhsin, E. Ali, S. Suleiman, and S. Ahmed, Clones in Natural Infections in an Area of Highly Seasonal Transmission, The Journal of Infectious Diseases, vol.185, issue.12, pp.1838-1842, 2002.
DOI : 10.1086/340638

J. Bousema, L. Gouagna, C. Drakeley, A. Meutstege, and B. Okech, Plasmodium falciparum gametocyte carriage in asymptomatic children in western Kenya, Malaria Journal, vol.3, issue.1, p.18, 2004.
DOI : 10.1186/1475-2875-3-18

P. Schneider, J. Bousema, L. Gouagna, S. Otieno, and M. Van-de-vegte-bolmer, Submicroscopic Plasmodium falciparum gametocyte densities frequently result in mosquito infection, Am J Trop Med Hyg, vol.76, pp.470-474, 2007.

S. Shekalaghe, J. Bousema, K. Kunei, P. Lushino, and A. Masokoto, Submicroscopic Plasmodium falciparum gametocyte carriage is common in an area of low and seasonal transmission in Tanzania, Tropical Medicine & International Health, vol.29, issue.4, pp.547-553, 2007.
DOI : 10.1111/j.1365-3156.2007.01821.x

S. Dunyo, P. Milligan, T. Edwards, C. Sutherland, and G. Targett, Gametocytaemia after Drug Treatment of Asymptomatic Plasmodium falciparum, PLoS Clinical Trials, vol.62, issue.4, p.20, 2006.
DOI : 10.1371/journal.pctr.0010020.sd002

D. Kwiatkowski, How Malaria Has Affected the Human Genome and What Human Genetics Can Teach Us about Malaria, The American Journal of Human Genetics, vol.77, issue.2, pp.171-192, 2005.
DOI : 10.1086/432519

A. Allison, Protection Afforded by Sickle-cell Trait Against Subtertian Malarial Infection, BMJ, vol.1, issue.4857, pp.290-294, 1954.
DOI : 10.1136/bmj.1.4857.290

D. Weatherall, J. Ledingham, and D. Warrell, Oxford Textbook of Medicine, 2003.

J. Haldane, THE RATE OF MUTATION OF HUMAN GENES, Hereditas, vol.XIV, issue.S1, pp.267-272, 1949.
DOI : 10.1111/j.1601-5223.1949.tb03339.x

E. Perry, Endemic Malaria of the Jeypore Hill Tracts of the Madras Presidency, Indian Journal of Medical Research, vol.2, p.459, 1914.

J. Baird, T. Jones, . Purnomo, S. Masbar, and S. Ratiwayanto, Evidence for specific suppression of gametocytemia by Plasmodium falciparum in residents of hyperendemic Irian Jaya, Am J Trop Med Hyg, vol.44, pp.183-190, 1991.

G. Paganotti, C. Palladino, D. Modiano, B. Sirima, and L. Råberg, Genetic complexity and gametocyte production of Plasmodium falciparum in Fulani and Mossi communities in Burkina Faso, Parasitology, vol.33, issue.05, pp.607-614, 2006.
DOI : 10.1098/rspb.2001.1808

L. Abel, M. Cot, L. Mulder, P. Carnevale, and J. Feingold, Segregation analysis detects a major gene controlling blood infection levels in human malaria, 1992.

A. Garcia, M. Cot, J. Chippaux, S. Ranque, and J. Feingold, Genetic control of blood infection levels in human malaria: evidence for a complex genetic model, Am J Trop Med Hyg, vol.58, pp.480-488, 1998.

A. Garcia, S. Marquet, B. Bucheton, D. Hillaire, and M. Cot, Linkage analysis of blood Plasmodium falciparum levels: interest of the 5q31?q33 chromosome region, Am J Trop Med Hyg, vol.58, pp.705-709, 1998.

P. Rihet, L. Abel, Y. Traore, T. Traore-leroux, and C. Aucan, Human malaria: Segregation analysis of blood infection levels in a suburban area and a rural area in Burkina Faso, Genetic Epidemiology, vol.56, issue.5, pp.435-450, 1998.
DOI : 10.1002/(SICI)1098-2272(1998)15:5<435::AID-GEPI1>3.0.CO;2-#

P. Rihet, Y. Traore, L. Abel, C. Aucan, and T. Traore-leroux, Malaria in Humans: Plasmodium falciparum Blood Infection Levels Are Linked to Chromosome 5q31-q33, The American Journal of Human Genetics, vol.63, issue.2, pp.498-505, 1998.
DOI : 10.1086/301967

R. Paul, T. Coulson, A. Raibaud, and P. Brey, Sex Determination in Malaria Parasites, Science, vol.287, issue.5450, pp.128-131, 2000.
DOI : 10.1126/science.287.5450.128

R. Paul, P. Brey, and V. Robert, Plasmodium sex determination and transmission to mosquitoes, Trends in Parasitology, vol.18, issue.1, pp.32-38, 2002.
DOI : 10.1016/S1471-4922(01)02122-5

D. Weatherall, Common genetic disorders of the red cell and the ???malaria hypothesis???, Annals of Tropical Medicine & Parasitology, vol.60, issue.35, pp.539-548, 1987.
DOI : 10.1080/00034983.1987.11812155

L. Gouagna, G. Bancone, F. Yao, B. Yameogo, and K. Dabiré, Genetic variation in human HBB is associated with Plasmodium falciparum transmission, Nature Genetics, vol.13, issue.4, pp.328-331, 2010.
DOI : 10.1038/ng.554

R. Paul, F. Ariey, and V. Robert, The evolutionary ecology of Plasmodium, Ecology Letters, vol.66, issue.9, pp.866-880, 2003.
DOI : 10.1016/S1471-4922(01)02058-X

R. Carter, K. Mendis, L. Miller, L. Molineaux, and A. Saul, Malaria transmission-blocking vaccines?how can their development be supported, Nature Medicine, vol.6, issue.3, pp.241-244, 2000.
DOI : 10.1038/73062

S. Khan, B. Franke-fayard, G. Mair, E. Lasonder, and C. Janse, Proteome Analysis of Separated Male and Female Gametocytes Reveals Novel Sex-Specific Plasmodium Biology, Cell, vol.121, issue.5, pp.675-687, 2005.
DOI : 10.1016/j.cell.2005.03.027

P. Graves, R. Carter, and K. Mcneill, Gametocyte production in cloned lines of Plasmodium falciparum, Am J Trop Med Hyg, vol.33, pp.1045-1050, 1984.

D. Weatherall, Phenotype?genotype relationships in monogenic disease: lessons from the thalassaemias, Nature Reviews Genetics, vol.2, issue.4, pp.245-255, 2001.
DOI : 10.1038/35066048

J. Trape, C. Rogier, L. Konate, N. Diagne, and H. Bouganali, The Dielmo project: a longitudinal study of natural malaria infection and the mechanisms of protective immunity in a community living in a holoendemic area of Senegal, Am J Trop Med Hyg, vol.51, pp.123-137, 1994.

C. Rogier, A. Tall, N. Diagne, D. Fontenille, and A. Spiegel, Plasmodium falciparum clinical malaria: lessons from longitudinal studies in Senegal, Parassitologia, vol.41, pp.255-259, 1999.

A. Sakuntabhai, R. Ndiaye, I. Casadémont, C. Peerapittayamonkol, and C. Rogier, Genetic Determination and Linkage Mapping of Plasmodium falciparum Malaria Related Traits in Senegal, PLoS ONE, vol.71, issue.4, p.2000, 2008.
DOI : 10.1371/journal.pone.0002000.t003

W. Phimpraphi, R. Paul, S. Yimsamran, S. Puangsa-art, and N. Thanyavanich, Longitudinal study of Plasmodium falciparum and Plasmodium vivax in a Karen population in Thailand, Malaria Journal, vol.7, issue.1, p.99, 2008.
DOI : 10.1186/1475-2875-7-99

D. Fontenille, L. Lochouarn, N. Diagne, C. Sokhna, and J. Lemasson, High annual and seasonal variations in malaria transmission by anophelines and vector species composition in Dielmo, a holoendemic area in Senegal, Am J Trop Med Hyg, vol.56, pp.247-253, 1997.

D. Fontenille, L. Lochouarn, M. Diatta, C. Sokhna, and I. Dia, Four years' entomological study of the transmission of seasonal malaria in Senegal and the bionomics of Anopheles gambiae and A. arabiensis, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.91, issue.6, pp.647-652, 1997.
DOI : 10.1016/S0035-9203(97)90506-X

N. Cancre, A. Tall, C. Rogier, F. J. Sarr, and O. , Bayesian Analysis of an Epidemiologic Model of Plasmodium falciparum Malaria Infection in Ndiop, Senegal, American Journal of Epidemiology, vol.152, issue.8, pp.760-770, 2000.
DOI : 10.1093/aje/152.8.760

URL : https://hal.archives-ouvertes.fr/ineris-00961851

C. Rogier, D. Commenges, and J. Trape, Evidence for an age-dependent pyrogenic threshold of Plasmodium falciparum parasitemia in highly endemic populations, Am J Trop Med Hyg, vol.54, pp.613-619, 1996.

R. Muirhead-thomson, Low Gametocyte Thresholds of Infection of Anopheles with Plasmodium Falciparum, BMJ, vol.1, issue.4853, pp.68-70, 1954.
DOI : 10.1136/bmj.1.4853.68

G. Jeffery and D. Eyles, Infectivity to mosquitoes of Plasmodium falciparum as related to gametocyte density and duration of infection, Am J Trop Med Hyg, vol.4, pp.781-789, 1955.

M. Oesterholt, M. Alifrangis, C. Sutherland, S. Omar, and P. Sawa, Submicroscopic Gametocytes and the Transmission of Antifolate-Resistant Plasmodium falciparum in Western Kenya, PLoS ONE, vol.36, issue.2, p.4364, 2009.
DOI : 10.1371/journal.pone.0004364.t002

C. Drakeley, K. Flobbe, B. Greenwood, and G. Targett, gametocytes in Gambian adults, Annals of Tropical Medicine & Parasitology, vol.59, issue.4, pp.399-401, 2000.
DOI : 10.1017/S0031182000047478

M. Smalley and R. Sinden, Plasmodium falciparum gametocytes: their longevity and infectivity, Parasitology, vol.64, issue.01, pp.1-8, 1977.
DOI : 10.1038/192733a0

G. Snounou, S. Viriyakosol, W. Jarra, S. Thaithong, and K. Brown, Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections, Molecular and Biochemical Parasitology, vol.58, issue.2, pp.283-292, 1993.
DOI : 10.1016/0166-6851(93)90050-8

L. Roch, K. Zhou, Y. Blair, P. Grainger, M. Moch et al., Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle, Science, vol.301, issue.5639, pp.1503-1508, 2003.
DOI : 10.1126/science.1087025

S. Rozen and H. Skaletsky, Primer3 on the WWW for General Users and for Biologist Programmers, Bioinformatics Methods and Protocols: Methods in Molecular Biology, pp.365-386, 2000.
DOI : 10.1385/1-59259-192-2:365

S. Chong, C. Boehm, D. Higgs, and G. Cutting, Single-tube multiplex- PCR screen for common deletional determinants of alpha-thalassemia, Blood, vol.95, pp.360-362, 2000.

L. Almasy and J. Blangero, Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees, The American Journal of Human Genetics, vol.62, issue.5, pp.1198-1211, 1998.
DOI : 10.1086/301844

W. Phimpraphi, R. Paul, B. Witoonpanich, C. Turbpaiboon, and C. Peerapittayamongkol, Heritability of P. falciparum and P. vivax Malaria in a Karen Population in Thailand, PLoS ONE, vol.9, issue.12, p.3887, 2008.
DOI : 10.1371/journal.pone.0003887.t006

R. Carter and P. Graves, Gametocytes. In: Wernsdorfer WH, McGregor I, eds. Malaria. Principles and practice of malariology, pp.1-59, 1988.

M. Mackinnon, T. Mwangi, R. Snow, K. Marsh, and T. Williams, Heritability of Malaria in Africa, PLoS Medicine, vol.97, issue.12, p.340, 2005.
DOI : 10.1371/journal.pmed.0020340.t001

C. Timmann, J. Evans, I. Konig, A. Kleensang, and F. Ruschendorf, Genome-Wide Linkage Analysis of Malaria Infection Intensity and Mild Disease, PLoS Genetics, vol.71, issue.3, p.48, 2007.
DOI : 0002-9297(2002)071[0238:PRQLAO]2.0.CO;2

M. Mackinnon, D. Gunawardena, J. Rajakaruna, S. Weerasingha, and K. Mendis, Quantifying genetic and nongenetic contributions to malarial infection in a Sri Lankan population, Proceedings of the National Academy of Sciences, vol.97, issue.23, pp.12661-12666, 2000.
DOI : 10.1073/pnas.220267997

B. Greenwood, Asymptomatic malaria infections ??? Do they matter?, Parasitology Today, vol.3, issue.7, pp.206-214, 1987.
DOI : 10.1016/0169-4758(87)90061-5

J. Flint, A. Hill, D. Bowden, S. Oppenheimer, and P. Sill, High frequencies of ??-thalassaemia are the result of natural selection by malaria, Nature, vol.38, issue.6072, pp.744-750, 1986.
DOI : 10.1038/321744a0

T. Williams, K. Maitland, S. Bennett, M. Ganczakowski, and T. Peto, High incidence of malaria in ??-thalassaemic children, Nature, vol.383, issue.6600, pp.522-525, 1996.
DOI : 10.1038/383522a0

V. Robert, T. Tchuinkam, B. Mulder, J. Bodo, and J. Verhave, Effect of the sickle cell trait status of gametocyte carriers of Plasmodium falciparum on infectivity to anophelines, Am J Trop Med Hyg, vol.54, pp.111-113, 1996.

D. Wilson, Rural hyper-endemic malaria in Tanganyika Territory, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.29, issue.6, pp.583-618, 1936.
DOI : 10.1016/S0035-9203(36)90040-8

G. Macdonald, COMMUNITY ASPECTS OF IMMUNITIY TO MALARIA, British Medical Bulletin, vol.8, issue.1, pp.33-36, 1951.
DOI : 10.1093/oxfordjournals.bmb.a074051

R. Rosenberg, R. Andre, and S. Ketrangsee, Seasonal fluctuation of Plasmodium falciparum gametocytaemia, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.84, issue.1, pp.29-33, 1990.
DOI : 10.1016/0035-9203(90)90369-P

R. Paul, M. Diallo, and P. Brey, Mosquitoes and transmission of malaria parasites ? not just vectors, Malaria Journal, vol.3, issue.1, p.39, 2004.
DOI : 10.1186/1475-2875-3-39

C. Drakeley, I. Carneiro, H. Reyburn, R. Malima, and J. Lusingu, Prevalence in Northeastern Tanzania, The Journal of Infectious Diseases, vol.191, issue.10, pp.1589-1598, 2005.
DOI : 10.1086/429669

R. Hayward, B. Tiwari, K. Piper, D. Baruch, and K. Day, Virulence and transmission success of the malarial parasite Plasmodium falciparum, Proceedings of the National Academy of Sciences, vol.96, issue.8, pp.4563-4568, 1999.
DOI : 10.1073/pnas.96.8.4563

K. Piper, R. Hayward, M. Cox, and K. Day, Malaria transmission and naturally acquired immunity to PfEMP-1, Infect Immun, vol.67, pp.6369-6374, 1999.

C. Drakeley, C. Sutherland, J. Bousema, R. Sauerwein, and G. Targett, The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersion, Trends in Parasitology, vol.22, issue.9, pp.424-430, 2006.
DOI : 10.1016/j.pt.2006.07.001

M. Saeed, W. Roeffen, N. Alexander, C. Drakeley, and G. Targett, Plasmodium falciparum Antigens on the Surface of the Gametocyte-Infected Erythrocyte, PLoS ONE, vol.25, issue.4, p.2280, 2008.
DOI : 10.1371/journal.pone.0002280.t002

M. Smalley and J. Brown, Plasmodium falciparum gametocytogenesis stimulated by lymphocytes and serum from infected Gambian children, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.75, issue.2, pp.316-317, 1981.
DOI : 10.1016/0035-9203(81)90348-5

D. Kwiatkowski, I. Sambou, P. Twumasi, B. Greenwood, and A. Hill, TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria, The Lancet, vol.336, issue.8725, pp.1201-1204, 1990.
DOI : 10.1016/0140-6736(90)92827-5

M. Dyer and K. Day, Commitment to Gametocytogenesis in Plasmodium falciparum, Parasitology Today, vol.16, issue.3, pp.102-107, 2000.
DOI : 10.1016/S0169-4758(99)01608-7

E. Nassir, A. Abdel-muhsin, S. Suliaman, F. Kenyon, and A. Kheir, Impact of genetic complexity on longevity and gametocytogenesis of Plasmodium falciparum during the dry and transmission-free season of eastern Sudan, International Journal for Parasitology, vol.35, issue.1, pp.49-55, 2005.
DOI : 10.1016/j.ijpara.2004.10.014

J. Bousema, C. Drakeley, P. Mens, T. Arens, and R. Houben, Increased Plasmodium falciparum gametocyte production in mixed infections with P. malariae, Am J Trop Med Hyg, vol.78, pp.442-448, 2008.