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High sensitivity and specificity of the Pastorex latex agglutination test for Neisseria meningitidis serogroup A during a clinical trial in Niger.

Abstract : There is a great need for a rapid diagnostic test to guide vaccine choice during outbreaks of meningococcal meningitis in resource-poor countries. During a randomised clinical trial conducted during an epidemic of Neisseria meningitidis serogroup A in Niger in 2003, the sensitivity and specificity of the Pastorex latex agglutination test for this serogroup under optimal field conditions were assessed, using culture and/or PCR as the gold standard. Results from 484 samples showed a sensitivity of 88% (95% CI 85-91%) and a specificity of 93% (95% CI 90-95%). Pastorex could be a good alternative to current methods, as it can be performed in a local laboratory with rapid results and is highly specific. Sensitivity can be improved with prior microscopy where feasible. A study specifically to evaluate the Pastorex test under epidemic conditions, using laboratories with limited resources, is recommended.
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https://hal-riip.archives-ouvertes.fr/pasteur-00561847
Contributor : Sani Haladou <>
Submitted on : Wednesday, February 2, 2011 - 10:28:42 AM
Last modification on : Monday, October 8, 2018 - 5:44:05 PM

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T. Borel, A. M. C. Rose, M. Guillerm, F. Sidikou, S. Gerstl, et al.. High sensitivity and specificity of the Pastorex latex agglutination test for Neisseria meningitidis serogroup A during a clinical trial in Niger.. Transactions of the Royal Society of Tropical Medicine and Hygiene / Transactions of the Royal Society for Tropical Medicine and Hygiene, 2006, 100 (10), pp.964-9. ⟨10.1016/j.trstmh.2006.03.002⟩. ⟨pasteur-00561847⟩

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