Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: a randomised non-inferiority study.

N. Nathan 1 T. Borel 1 A. Djibo 2 D. Evans 1 S. Djibo 3 J. F. Corty 4 M. Guillerm 4 K. P. Alberti 1 L. Pinoges 1 P. J. Guerin 1, * D. Legros 1
* Corresponding author
1 Epicentre [Paris] [Médecins Sans Frontières]
2 Ministère de la Santé Publique et de la Lutte contre les Endémies
3 CERMES - Centre de Recherche Médicale et Sanitaire (Niamey, Niger)
4 MSF - Médecins Sans Frontières
Abstract : Single-dose ceftriaxone provides an alternative treatment for epidemic meningococcal meningitis--its efficacy, ease of use, and low cost favour its use. National and international health partners should consider ceftriaxone as an alternative first-line treatment to chloramphenicol for epidemic meningococcal meningitis.
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Submitted on : Wednesday, February 2, 2011 - 10:47:46 AM
Last modification on : Monday, October 8, 2018 - 5:44:05 PM

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N. Nathan, T. Borel, A. Djibo, D. Evans, S. Djibo, et al.. Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: a randomised non-inferiority study.. The Lancet, Elsevier, 2005, 366 (9482), pp.308-13. ⟨10.1016/S0140-6736(05)66792-X⟩. ⟨pasteur-00561858⟩

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