Immunogenicity, safety, and memory of different schedules of Neisseria meningitidis A/C-diphtheria toxoid conjugate vaccine in infants in Niger. - RIIP - Réseau International des Instituts Pasteur Accéder directement au contenu
Article Dans Une Revue Vaccine Année : 2004

Immunogenicity, safety, and memory of different schedules of Neisseria meningitidis A/C-diphtheria toxoid conjugate vaccine in infants in Niger.

Résumé

We studied one to four doses of meningococcal polysaccharides A and C conjugated to diphtheria toxoid (Men D) versus A/C polysaccharide (Men PS) vaccine in 618 infants in Niger. Men PS at 24 months permitted evaluating memory. Two Men D doses (at 3 and 9 months) induced higher serum bactericidal activity (SBA) than other regimens. SBA titers after Men PS at 24 months were higher in those given Men D in infancy versus Men PS. While responses were lower for serogroup C, hyporesponsiveness was not evident. Men D was well-tolerated. A single Men D dose in infancy appeared to induce memory.

Dates et versions

pasteur-00561871 , version 1 (02-02-2011)

Identifiants

Citer

J.-P. Chippaux, A. Garba, C. Ethevenaux, G. Campagne, F. de Chabalier, et al.. Immunogenicity, safety, and memory of different schedules of Neisseria meningitidis A/C-diphtheria toxoid conjugate vaccine in infants in Niger.. Vaccine, 2004, 22 (25-26), pp.3303-11. ⟨10.1016/j.vaccine.2004.02.028⟩. ⟨pasteur-00561871⟩
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