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Immunogenicity, safety, and memory of different schedules of Neisseria meningitidis A/C-diphtheria toxoid conjugate vaccine in infants in Niger.

J.-P. Chippaux 1 A. Garba 1 C. Ethevenaux 2 G. Campagne 1 F. de Chabalier 1 S. Djibo 1 P. Nicolas 3 H. Ali 1 M. Charrondière 2 R. Ryall 2 M. Bybel 2 A. Schuchat 4
1 CERMES - Centre de Recherche Médicale et Sanitaire (Niamey, Niger)
2 AVENTIS PASTEUR SA
3 IMTSSA - Institut de Médecine Tropicale du Service de Santé des Armées
4 CDC - Centers for Disease Control and Prevention [Atlanta]
Abstract : We studied one to four doses of meningococcal polysaccharides A and C conjugated to diphtheria toxoid (Men D) versus A/C polysaccharide (Men PS) vaccine in 618 infants in Niger. Men PS at 24 months permitted evaluating memory. Two Men D doses (at 3 and 9 months) induced higher serum bactericidal activity (SBA) than other regimens. SBA titers after Men PS at 24 months were higher in those given Men D in infancy versus Men PS. While responses were lower for serogroup C, hyporesponsiveness was not evident. Men D was well-tolerated. A single Men D dose in infancy appeared to induce memory.
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https://hal-riip.archives-ouvertes.fr/pasteur-00561871
Contributor : Sani Haladou <>
Submitted on : Wednesday, February 2, 2011 - 11:00:18 AM
Last modification on : Tuesday, December 11, 2018 - 2:06:02 PM

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J.-P. Chippaux, A. Garba, C. Ethevenaux, G. Campagne, F. de Chabalier, et al.. Immunogenicity, safety, and memory of different schedules of Neisseria meningitidis A/C-diphtheria toxoid conjugate vaccine in infants in Niger.. Vaccine, Elsevier, 2004, 22 (25-26), pp.3303-11. ⟨10.1016/j.vaccine.2004.02.028⟩. ⟨pasteur-00561871⟩

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