Immunogenicity, safety, and memory of different schedules of Neisseria meningitidis A/C-diphtheria toxoid conjugate vaccine in infants in Niger.

J.-P. Chippaux (1) , A. Garba (1) , C. Ethevenaux (2) , G. Campagne (1) , F. de Chabalier (1) , S. Djibo (1) , P. Nicolas (3) , H. Ali (1) , M. Charrondière (2) , R. Ryall (2) , M. Bybel (2) , A. Schuchat (4)

1 CERMES - Centre de Recherche Médicale et Sanitaire (Niamey, Niger)
2 AVENTIS PASTEUR SA
3 IMTSSA - Institut de Médecine Tropicale du Service de Santé des Armées
4 CDC - Centers for Disease Control and Prevention [Atlanta]

We studied one to four doses of meningococcal polysaccharides A and C conjugated to diphtheria toxoid (Men D) versus A/C polysaccharide (Men PS) vaccine in 618 infants in Niger. Men PS at 24 months permitted evaluating memory. Two Men D doses (at 3 and 9 months) induced higher serum bactericidal activity (SBA) than other regimens. SBA titers after Men PS at 24 months were higher in those given Men D in infancy versus Men PS. While responses were lower for serogroup C, hyporesponsiveness was not evident. Men D was well-tolerated. A single Men D dose in infancy appeared to induce memory.

Domains: Life Sciences [q-bio]; Microbiology and Parasitology

J.-P. Chippaux, A. Garba, C. Ethevenaux, G. Campagne, F. de Chabalier, et al.. Immunogenicity, safety, and memory of different schedules of Neisseria meningitidis A/C-diphtheria toxoid conjugate vaccine in infants in Niger.. Vaccine, 2004, 22 (25-26), pp.3303-11. ⟨10.1016/j.vaccine.2004.02.028⟩. ⟨pasteur-00561871⟩