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Journal articles
Immunogenicity, safety, and memory of different schedules of Neisseria meningitidis A/C-diphtheria toxoid conjugate vaccine in infants in Niger.
J.-P. Chippaux
1
A. Garba
1
C. Ethevenaux
2
G. Campagne
1
F. de Chabalier
1
S. Djibo
1
P. Nicolas
3
H. Ali
1
M. Charrondière
2
R. Ryall
2
M. Bybel
2
A. Schuchat
4
1
CERMES - Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (BP 10887 Niamey - Niger)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
2
AVENTIS PASTEUR SA (1541 Avenue Marcel Mérieux 69280 MARCY L'Etoile - France)
- AVENTIS PASTEUR (France)
3
IMTSSA - Institut de Médecine Tropicale du Service de Santé des Armées (BP 50 13998 Marseille Armées. - France)
- Service de Santé des Armées (France)
4
CDC - Centers for Disease Control and Prevention [Atlanta] (1600 Clifton Rd. GA 30333 Atlanta, GA - United States)
- Centers for Disease Control and Prevention (United States)
Abstract : We studied one to four doses of meningococcal polysaccharides A and C conjugated to diphtheria toxoid (Men D) versus A/C polysaccharide (Men PS) vaccine in 618 infants in Niger. Men PS at 24 months permitted evaluating memory. Two Men D doses (at 3 and 9 months) induced higher serum bactericidal activity (SBA) than other regimens. SBA titers after Men PS at 24 months were higher in those given Men D in infancy versus Men PS. While responses were lower for serogroup C, hyporesponsiveness was not evident. Men D was well-tolerated. A single Men D dose in infancy appeared to induce memory.
Document type :
Journal articles
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https://hal-riip.archives-ouvertes.fr/pasteur-00561871
Contributor : Sani Haladou Connect in order to contact the contributor
Submitted on : Wednesday, February 2, 2011 - 11:00:18 AM
Last modification on : Tuesday, December 11, 2018 - 2:06:02 PM
Contributor : Sani Haladou Connect in order to contact the contributor
Submitted on : Wednesday, February 2, 2011 - 11:00:18 AM
Last modification on : Tuesday, December 11, 2018 - 2:06:02 PM
Identifiers
- HAL Id : pasteur-00561871, version 1
- DOI : 10.1016/j.vaccine.2004.02.028
- PUBMED : 15308353
Collections
SSA | RIIP | RIIP_CERMES
Citation
J.-P. Chippaux, A. Garba, C. Ethevenaux, G. Campagne, F. de Chabalier, et al.. Immunogenicity, safety, and memory of different schedules of Neisseria meningitidis A/C-diphtheria toxoid conjugate vaccine in infants in Niger.. Vaccine, Elsevier, 2004, 22 (25-26), pp.3303-11. ⟨10.1016/j.vaccine.2004.02.028⟩. ⟨pasteur-00561871⟩
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