C. Shepard, L. Finelli, and M. Alter, Global epidemiology of hepatitis C virus infection, The Lancet Infectious Diseases, vol.5, issue.9, pp.558-567, 2005.
DOI : 10.1016/S1473-3099(05)70216-4

T. Suzuki, H. Aizaki, K. Murakami, I. Shoji, and T. Wakita, Molecular biology of hepatitis C virus, Journal of Gastroenterology, vol.272, issue.Pt 6, pp.411-423, 2007.
DOI : 10.1007/s00535-007-2030-3

A. Varaklioti, N. Vassilaki, U. Georgopoulou, and P. Mavromara, Alternate Translation Occurs within the Core Coding Region of the Hepatitis C Viral Genome, Journal of Biological Chemistry, vol.277, issue.20, 2002.
DOI : 10.1074/jbc.M201722200

Z. Xu, J. Choi, T. Yen, W. Lu, and A. Strohecker, Synthesis of a novel hepatitis C virus protein by ribosomal frameshift, The EMBO Journal, vol.20, issue.14, pp.3840-3848, 2001.
DOI : 10.1093/emboj/20.14.3840

M. Baril and L. Brakier-gingras, Translation of the F protein of hepatitis C virus is initiated at a non-AUG codon in a +1 reading frame relative to the polyprotein, Nucleic Acids Research, vol.33, issue.5, pp.1474-1486, 2005.
DOI : 10.1093/nar/gki292

J. Roussel, A. Pillez, C. Montpellier, G. Duverlie, and A. Cahour, Characterization of the expression of the hepatitis C virus F protein, Journal of General Virology, vol.84, issue.7, pp.1751-1759, 2003.
DOI : 10.1099/vir.0.19065-0

N. Vassilaki and P. Mavromara, Two Alternative Translation Mechanisms Are Responsible for the Expression of the HCV ARFP/F/Core+1 Coding Open Reading Frame, Journal of Biological Chemistry, vol.278, issue.42, pp.40503-40513, 2003.
DOI : 10.1074/jbc.M305504200

C. Bain, P. Parroche, J. Lavergne, B. Duverger, and C. Vieux, Memory T-Cell-Mediated Immune Responses Specific to an Alternative Core Protein in Hepatitis C Virus Infection, Journal of Virology, vol.78, issue.19, pp.10460-10469, 2004.
DOI : 10.1128/JVI.78.19.10460-10469.2004
URL : https://hal.archives-ouvertes.fr/hal-00313685

W. Chuang and J. Allain, Differential reactivity of putative genotype 2 hepatitis C virus F protein between chronic and recovered infections, Journal of General Virology, vol.89, issue.8, pp.1890-1900, 2008.
DOI : 10.1099/vir.0.83677-0

M. Cohen, L. Bachmatov, Z. Ben-ari, Y. Rotman, and R. Tur-kaspa, Development of Specific Antibodies to an ARF Protein in Treated Patients with Chronic HCV Infection, Digestive Diseases and Sciences, vol.300, issue.Suppl 2, pp.2427-2432, 2007.
DOI : 10.1007/s10620-006-9630-2

Y. Morice, M. Ratinier, A. Miladi, S. Chevaliez, and G. Germanidis, Seroconversion to hepatitis C virus alternate reading frame protein during acute infection, Hepatology, vol.277, issue.5, pp.1449-1459, 2009.
DOI : 10.1002/hep.22821
URL : https://hal.archives-ouvertes.fr/inserm-00385238

M. Troesch, E. Jalbert, S. Canobio, M. Boulassel, and J. Routy, Characterization of humoral and cell-mediated immune responses directed against hepatitis C virus F protein in subjects co-infected with hepatitis C virus and HIV-1, AIDS, vol.19, issue.8, pp.775-784, 2005.
DOI : 10.1097/01.aids.0000168971.57681.6e

W. Wu, S. Shao, L. Zhao, J. Luan, and J. Cao, Hepatitis C Virus F Protein Up-Regulates c-myc and Down-Regulates p53 in Human Hepatoma HepG₂ Cells, Intervirology, vol.50, issue.5, pp.341-346, 2007.
DOI : 10.1159/000107271

F. Komurian-pradel, A. Rajoharison, J. Berland, V. Khouri, and M. Perret, Antigenic relevance of F protein in chronic hepatitis C virus infection, Hepatology, vol.84, issue.4, pp.900-909, 2004.
DOI : 10.1002/hep.20406

N. Vassilaki, H. Boleti, and P. Mavromara, Expression studies of the HCV-1a core+1 open reading frame in mammalian cells, Virus Research, vol.133, issue.2, pp.123-135, 2008.
DOI : 10.1016/j.virusres.2007.10.019

S. Boulant, M. Becchi, F. Penin, and J. Lavergne, Unusual Multiple Recoding Events Leading to Alternative Forms of Hepatitis C Virus Core Protein from Genotype 1b, Journal of Biological Chemistry, vol.278, issue.46, pp.45785-45792, 2003.
DOI : 10.1074/jbc.M307174200
URL : https://hal.archives-ouvertes.fr/hal-00313696

M. Ratinier, C. Boulant, C. Combet, P. Targett-addams, J. Mclauchlan et al., Transcriptional slippage prompts recoding in alternate reading frames in the hepatitis C virus (HCV) core sequence from strain HCV-1, Journal of General Virology, vol.89, issue.7, 2008.
DOI : 10.1099/vir.0.83614-0
URL : https://hal.archives-ouvertes.fr/hal-00315260

C. Yeh, S. Lu, C. Chu, and Y. Liaw, Molecular cloning of a defective hepatitis C virus genome from the ascitic fluid of a patient with hepatocellular carcinoma., Journal of General Virology, vol.78, issue.11, pp.2761-2770, 1997.
DOI : 10.1099/0022-1317-78-11-2761

N. Vassilaki, H. Boleti, and P. Mavromara, Expression studies of the core+1 protein of the hepatitis???C virus 1a in mammalian cells, FEBS Journal, vol.78, issue.16, pp.4057-4074, 2007.
DOI : 10.1111/j.1742-4658.2007.05929.x

K. Yuksek, W. Chen, D. Chien, and J. Ou, Ubiquitin-Independent Degradation of Hepatitis C Virus F Protein, Journal of Virology, vol.83, issue.2, pp.612-621, 2009.
DOI : 10.1128/JVI.00832-08

V. Lohmann, HCV Replicons: Overview and Basic Protocols, Methods Mol Biol, vol.510, pp.145-163, 2009.
DOI : 10.1007/978-1-59745-394-3_11

L. Mcmullan, A. Grakoui, M. Evans, K. Mihalik, and M. Puig, Evidence for a functional RNA element in the hepatitis C virus core gene, Proceedings of the National Academy of Sciences, vol.104, issue.8, pp.2879-2884, 2007.
DOI : 10.1073/pnas.0611267104

N. Vassilaki and P. Mavromara, The HCV ARFP/F/core+1 protein: Production and functional analysis of an unconventional viral product, IUBMB Life, vol.76, issue.Part 11, pp.739-752, 2009.
DOI : 10.1002/iub.201

T. Tellinghuisen and C. Rice, Interaction between hepatitis C virus proteins and host cell factors, Current Opinion in Microbiology, vol.5, issue.4, pp.419-427, 2002.
DOI : 10.1016/S1369-5274(02)00341-7

M. Irshad and I. Dhar, Hepatitis C Virus Core Protein: An Update on Its Molecular Biology, Cellular Functions and Clinical Implications, Medical Principles and Practice, vol.15, issue.6, pp.405-416, 2006.
DOI : 10.1159/000095485

M. Fiorucci, . Bs, A. Fournillier, J. Abraham, J. Lavergne et al., Expression of the alternative reading frame protein of Hepatitis C virus induces cytokines involved in hepatic injuries, Journal of General Virology, vol.88, issue.4, pp.1149-1162, 2007.
DOI : 10.1099/vir.0.82575-0
URL : https://hal.archives-ouvertes.fr/hal-00315111

A. Basu, R. Steele, R. Ray, and R. Ray, Functional properties of a 16 kDa protein translated from an alternative open reading frame of the core-encoding genomic region of hepatitis C virus, Journal of General Virology, vol.85, issue.8, pp.2299-2306, 2004.
DOI : 10.1099/vir.0.80028-0

M. Tsao, C. Chao, and C. Yeh, Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization, Biochemical and Biophysical Research Communications, vol.348, issue.1, pp.271-277, 2006.
DOI : 10.1016/j.bbrc.2006.07.062

S. Shao, W. Wu, Z. Bian, J. Yu, and P. Zhao, Hepatitis C virus F protein inhibits cell apoptosis by activation of intracellular NF-??B pathway, Hepatology Research, vol.79, issue.3, pp.282-289, 2009.
DOI : 10.1111/j.1872-034X.2008.00452.x

L. Imberti, E. Cariani, A. Bettinardi, A. Zonaro, and A. Albertini, An immunoassay for specific amplified HCV sequences, Journal of Virological Methods, vol.34, issue.3, pp.233-243, 1991.
DOI : 10.1016/0166-0934(91)90103-7

H. Okamoto, S. Okada, Y. Sugiyama, S. Yotsumoto, and T. Tanaka, The 59-terminal sequence of the hepatitis C virus genome Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 59-noncoding region, Jpn J Exp Med, vol.60, pp.167-177, 1990.

J. Felsenstein and G. Churchill, A Hidden Markov Model approach to variation among sites in rate of evolution, Molecular Biology and Evolution, vol.13, issue.1, pp.93-104, 1996.
DOI : 10.1093/oxfordjournals.molbev.a025575

P. Tsitoura, U. Georgopoulou, S. Petres, A. Varaklioti, and A. Karafoulidou, Evidence for cellular uptake of recombinant hepatitis C virus non-enveloped capsid-like particles, FEBS Letters, vol.281, issue.21, pp.4049-4057, 2007.
DOI : 10.1016/j.febslet.2007.07.032

A. Boumlic, Y. Nomine, S. Charbonnier, G. Dalagiorgou, and N. Vassilaki, Prevalence of intrinsic disorder in the hepatitis???C virus ARFP/Core+1/S protein, FEBS Journal, vol.4, issue.Pt 11, pp.774-789
DOI : 10.1111/j.1742-4658.2009.07527.x

P. Martin, Automated RIBA hepatitis C virus (HCV) strip immunoblot assay for reproducible HCV diagnosis, J Clin Microbiol, vol.36, pp.387-390, 1998.

J. Pawlotsky, Influence of hepatitis C virus (HCV) genotypes on HCV recombinant immunoblot assay patterns, J Clin Microbiol, vol.33, pp.1357-1359, 1995.

A. Nagasaka, S. Hige, M. Kurosawa, J. Yoshida, and Y. Karino, Nucleotide sequences of the hepatitis C virus core region in patients without anti-core antibody, Journal of Medical Virology, vol.19, issue.2, pp.91-94, 1996.
DOI : 10.1002/(SICI)1096-9071(199606)49:2<91::AID-JMV4>3.0.CO;2-E

J. Chamary and L. Hurst, Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals, Genome Biology, vol.6, issue.9, p.75, 2005.
DOI : 10.1186/gb-2005-6-9-r75

A. Branch, D. Stump, J. Gutierrez, F. Eng, and J. Walewski, The Hepatitis C Virus Alternate Reading Frame (ARF) and Its Family of Novel Products: The Alternate Reading Frame Protein/F-Protein, the Double-Frameshift Protein, and Others, Seminars in Liver Disease, vol.25, issue.01, pp.105-117, 2005.
DOI : 10.1055/s-2005-864786

P. Goymer, Synonymous mutations break their silence, Nature Reviews Genetics, vol.7, issue.2, pp.92-92, 2007.
DOI : 10.1038/nrg2056

C. Kimchi-sarfaty, J. Oh, I. Kim, Z. Sauna, and A. Calcagno, A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity, Science, vol.315, issue.5811, pp.525-528, 2007.
DOI : 10.1126/science.1135308

F. Eng, J. Walewski, A. Klepper, S. Fishman, and S. Desai, Internal Initiation Stimulates Production of p8 Minicore, a Member of a Newly Discovered Family of Hepatitis C Virus Core Protein Isoforms, Journal of Virology, vol.83, issue.7, pp.3104-3114, 2009.
DOI : 10.1128/JVI.01679-08