Class and subclass selection in parasite-specific antibody responses.

Abstract : Antibodies are characteristically induced in many parasitic infection processes. The class and subclass of the antibody response is instrumental because each isotype has a distinct biological function. It is thus crucially important for an infected individual to mount the most appropriate secondary antibody response--that is the response that has the best chance of clearing the infection and/or controlling disease. This represents a fundamental of vaccine strategies. Immuno-epidemiological surveys and in vitro models of antibody production have helped to understand some of the goals which should be achieved when designing antiparasitic vaccines.
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Submitted on : Thursday, February 17, 2011 - 11:12:34 AM
Last modification on : Wednesday, December 4, 2019 - 11:14:05 AM

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Olivier Garraud, Ronald Perraut, Gilles Riveau, Thomas B Nutman. Class and subclass selection in parasite-specific antibody responses.. Trends in Parasitology, Elsevier, 2003, 19 (7), pp.300-4. ⟨10.1016/S1471-4922(03)00139-9⟩. ⟨pasteur-00566839⟩

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