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CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.

Abstract : Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632).
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https://hal-riip.archives-ouvertes.fr/pasteur-00583691
Contributor : Sébastien Breurec <>
Submitted on : Wednesday, April 6, 2011 - 12:18:27 PM
Last modification on : Thursday, September 5, 2019 - 3:18:09 PM

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Effrosini G Panayotopoulou, Dionyssios N Sgouras, Konstantinos S Papadakos, Kalliopi Petraki, Sébastien Breurec, et al.. CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.. Journal of Clinical Microbiology, American Society for Microbiology, 2010, 48 (6), pp.2237-9. ⟨10.1128/JCM.00662-10⟩. ⟨pasteur-00583691⟩

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