CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease. - Archive ouverte HAL Access content directly
Journal Articles Journal of Clinical Microbiology Year : 2010

CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.

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Abstract

Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632).

Dates and versions

pasteur-00583691 , version 1 (06-04-2011)

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Effrosini G Panayotopoulou, Dionyssios N Sgouras, Konstantinos S Papadakos, Kalliopi Petraki, Sébastien Breurec, et al.. CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.. Journal of Clinical Microbiology, 2010, 48 (6), pp.2237-9. ⟨10.1128/JCM.00662-10⟩. ⟨pasteur-00583691⟩
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