CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.

Effrosini G Panayotopoulou (1) , Dionyssios N Sgouras (1) , Konstantinos S Papadakos (1) , Kalliopi Petraki (1) , Sébastien Breurec (2) , Spyros Michopoulos (3) , Gerassimos J. Mantzaris (4) , George Papatheodoridis (5) , Andreas Mentis (1) , Athanasios Archimandritis (5)

1 Institut Pasteur Hellénique
2 Institut Pasteur de Dakar
3 Gastroenterology Clinic
4 Gastroenterology Clinic
5 Second Department of Internal Medicine

Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632).

Domains: Bacteriology

Effrosini G Panayotopoulou, Dionyssios N Sgouras, Konstantinos S Papadakos, Kalliopi Petraki, Sébastien Breurec, et al.. CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.. Journal of Clinical Microbiology, 2010, 48 (6), pp.2237-9. ⟨10.1128/JCM.00662-10⟩. ⟨pasteur-00583691⟩