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Journal articles
CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.
Effrosini G Panayotopoulou
1
Dionyssios N Sgouras
1, *
Konstantinos S Papadakos
1
Kalliopi Petraki
1
Sébastien Breurec
2
Spyros Michopoulos
3
Gerassimos Mantzaris
4
George Papatheodoridis
5
Andreas Mentis
1
Athanasios Archimandritis
5
*
Corresponding author
Effrosini G Panayotopoulou 1
Author
Dionyssios N Sgouras 1
Correspondent author
Konstantinos S Papadakos 1
Author
Kalliopi Petraki 1
Author
Sébastien Breurec 2
Author IdHAL : sebastien-breurec ORCID : https://orcid.org/0000-0003-4188-0377
Spyros Michopoulos 3
Author
Gerassimos J. Mantzaris 4
Author
George Papatheodoridis 5
Author
Andreas Mentis 1
Author
Athanasios Archimandritis 5
Author
1
Institut Pasteur Hellénique (127 avenue Vassilissis Sofias Athènes 115 21 - Greece)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
2
Institut Pasteur de Dakar (B.P. 220 Dakar - Senegal)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
5
Second Department of Internal Medicine (Athens - Greece)
- Athens University School of Medicine (France)
Abstract : Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632).
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Journal articles
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https://hal-riip.archives-ouvertes.fr/pasteur-00583691
Contributor : Sébastien Breurec <>
Submitted on : Wednesday, April 6, 2011 - 12:18:27 PM
Last modification on : Thursday, September 5, 2019 - 3:18:09 PM
Contributor : Sébastien Breurec <>
Submitted on : Wednesday, April 6, 2011 - 12:18:27 PM
Last modification on : Thursday, September 5, 2019 - 3:18:09 PM
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- HAL Id : pasteur-00583691, version 1
- DOI : 10.1128/JCM.00662-10
- PUBMED : 20392907
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Effrosini G Panayotopoulou, Dionyssios N Sgouras, Konstantinos S Papadakos, Kalliopi Petraki, Sébastien Breurec, et al.. CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.. Journal of Clinical Microbiology, American Society for Microbiology, 2010, 48 (6), pp.2237-9. ⟨10.1128/JCM.00662-10⟩. ⟨pasteur-00583691⟩
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