Evaluation of two new commercial tests for the diagnosis of acute dengue virus infection using NS1 antigen detection in human serum.

Philippe Dussart; Laure Petit; Bhety Labeau; Laetitia Bremand; Alexandre Leduc; David Moua; Séverine Matheus; Laurence Baril

Evaluation of two new commercial tests for the diagnosis of acute dengue virus infection using NS1 antigen detection in human serum.

Philippe Dussart ^{1, *} Laure Petit ² Bhety Labeau ¹ Laetitia Bremand ¹ Alexandre Leduc David Moua ¹ Séverine Matheus ¹ Laurence Baril ³

* Corresponding author

1 Institut Pasteur de la Guyane

2 Epidémiologie des Maladies Emergentes

3 Institut Pasteur de Dakar

Abstract : Our findings support the use of diagnostic tools based on the NS1 antigen detection for the diagnosis of acute DENV infection. The immunochromatographic test, Dengue NS1 Ag STRIP-the first rapid diagnostic test for DENV infection-was highly sensitive and specific, and would therefore be a suitable first-line test in the field. The pan-E Dengue Early ELISA was less sensitive than the Platelia test; this two-step ELISA should be combined with DENV IgM antibody detection for the diagnosis of DENV infection.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Microbiology and Parasitology / Virology

Complete list of metadatas

https://hal-riip.archives-ouvertes.fr/pasteur-00584083
Contributor : Séverine Matheus <>
Submitted on : Thursday, April 7, 2011 - 2:45:33 PM
Last modification on : Thursday, February 7, 2019 - 3:47:05 PM

Evaluation of two new commercial tests for the diagnosis of acute dengue virus infection using NS1 antigen detection in human serum.

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Evaluation of two new commercial tests for the diagnosis of acute dengue virus infection using NS1 antigen detection in human serum.

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