Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Antibiotic susceptibility of Helicobacter pylori isolates in Dakar, Senegal.

Abstract : Background: Helicobacter pylori is the primary cause of peptic ulcer disease and an etiologic agent in the development of gastric cancer. A high frequency of H. pylori infection has been reported from resource-poor regions. H. pylori infection is curable with regimens of multiple antimicrobial agents. However, antibiotic resistance is a leading cause of treatment failure. In Africa, there are very little data concerning the susceptibility of H. pylori isolates to antibiotics. Methodology: H. pylori isolates from gastric biopsies from outpatients ≥ 18 years old affected by a gastro-duodenal ulcer were used in this study. Susceptibility testing was performed for amoxicillin, ciprofloxacin and metronidazole by using the Epsilometer test (E-test) method. Results: H. pylori strains were isolated from 40 patients of whom 36 were diagnosed as having duodenal ulcer, two with gastric ulcer, and two with gastro-duodenal ulcer. Thirty-six (90%) of the isolates were resistant to metronidazole (MICs ≥ 8 µg/l), whereas all isolates were susceptible to amoxicillin (MICs ≤ 0. 5 µg/ml) and ciprofloxacin (MICs ≤ 1µg/ml). Conclusion: These data suggest that metronidazole should not be used therapeutically among Senegalese patients in first-line therapy, while ciprofloxacin could be recommended in association with amoxicillin and a proton pump inhibitor in Senegal.
Document type :
Journal articles
Complete list of metadata

Cited literature [20 references]  Display  Hide  Download
Contributor : Sébastien Breurec Connect in order to contact the contributor
Submitted on : Tuesday, May 3, 2011 - 4:55:48 PM
Last modification on : Monday, November 22, 2021 - 5:46:02 PM
Long-term archiving on: : Thursday, August 4, 2011 - 2:24:38 AM


Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution 4.0 International License




Abdoulaye Seck, Mouhamadou Mbengue, Amy Gassama-Sow, Lamine Diouf, Mouhamadou Mourtalla Ka, et al.. Antibiotic susceptibility of Helicobacter pylori isolates in Dakar, Senegal.. Journal of Infection in Developing Countries, Independent, 2009, 3 (2), pp.137-140. ⟨10.3855/jidc.512⟩. ⟨pasteur-00584222⟩



Record views


Files downloads