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Journal articles
Antibiotic susceptibility of Helicobacter pylori isolates in Dakar, Senegal.
Abstract : Background: Helicobacter pylori is the primary cause of peptic ulcer disease and an etiologic agent in the development of gastric cancer. A high frequency of H. pylori infection has been reported from resource-poor regions. H. pylori infection is curable with regimens of multiple antimicrobial agents. However, antibiotic resistance is a leading cause of treatment failure. In Africa, there are very little data concerning the susceptibility of H. pylori isolates to antibiotics.
Methodology: H. pylori isolates from gastric biopsies from outpatients ≥ 18 years old affected by a gastro-duodenal ulcer were used in this study. Susceptibility testing was performed for amoxicillin, ciprofloxacin and metronidazole by using the Epsilometer test (E-test) method.
Results: H. pylori strains were isolated from 40 patients of whom 36 were diagnosed as having duodenal ulcer, two with gastric ulcer, and two with gastro-duodenal ulcer. Thirty-six (90%) of the isolates were resistant to metronidazole (MICs ≥ 8 µg/l), whereas all isolates were susceptible to amoxicillin (MICs ≤ 0. 5 µg/ml) and ciprofloxacin (MICs ≤ 1µg/ml).
Conclusion: These data suggest that metronidazole should not be used therapeutically among Senegalese patients in first-line therapy, while ciprofloxacin could be recommended in association with amoxicillin and a proton pump inhibitor in Senegal.
Cited literature [20 references]
https://hal-riip.archives-ouvertes.fr/pasteur-00584222
Contributor : Sébastien Breurec Connect in order to contact the contributor
Submitted on : Tuesday, May 3, 2011 - 4:55:48 PM
Last modification on : Monday, November 22, 2021 - 5:46:02 PM
Long-term archiving on: : Thursday, August 4, 2011 - 2:24:38 AM
Contributor : Sébastien Breurec Connect in order to contact the contributor
Submitted on : Tuesday, May 3, 2011 - 4:55:48 PM
Last modification on : Monday, November 22, 2021 - 5:46:02 PM
Long-term archiving on: : Thursday, August 4, 2011 - 2:24:38 AM
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