J. S. Peiris, S. T. Lai, L. L. Poon, Y. Guan, L. Y. Yam et al., Coronavirus as a possible cause of severe acute respiratory syndrome, The Lancet, vol.361, issue.9366, pp.1319-1325, 2003.
DOI : 10.1016/S0140-6736(03)13077-2

R. A. Fouchier, T. Kuiken, M. Schutten, G. Van-amerongen, G. J. Van-doornum et al., Aetiology: Koch's postulates fulfilled for SARS virus, Nature, vol.78, issue.6937, 2003.
DOI : 10.1038/89098

E. J. Snijder, P. J. Bredenbeek, J. C. Dobbe, V. Thiel, J. Ziebuhr et al., Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage, Journal of Molecular Biology, vol.331, issue.5, pp.331-991, 2003.
DOI : 10.1016/S0022-2836(03)00865-9

Y. J. Tan, S. G. Lim, and W. Hong, Understanding the accessory viral proteins unique to the severe acute respiratory syndrome (SARS) coronavirus, Antiviral Research, vol.72, issue.2, pp.72-78, 2006.
DOI : 10.1016/j.antiviral.2006.05.010

R. L. Upton and . Roper, The Genome sequence of the SARS-associated coronavirus, Science, vol.300, pp.1399-1404, 2003.

K. Narayanan, C. Huang, and S. Makino, SARS coronavirus accessory proteins, SARS coronavirus accessory proteins, pp.113-121, 2008.
DOI : 10.1016/j.virusres.2007.10.009

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720074

S. Shen, P. S. Lin, Y. C. Chao, A. Zhang, X. Yang et al., The severe acute respiratory syndrome coronavirus 3a is a novel structural protein, Biochemical and Biophysical Research Communications, vol.330, issue.1, pp.330-286, 2005.
DOI : 10.1016/j.bbrc.2005.02.153

N. Ito, E. C. Mossel, K. Narayanan, V. L. Popov, C. Huang et al., Severe Acute Respiratory Syndrome Coronavirus 3a Protein Is a Viral Structural Protein, Journal of Virology, vol.79, issue.5, pp.79-3182, 2005.
DOI : 10.1128/JVI.79.5.3182-3186.2005

C. Huang, N. Ito, C. T. Tseng, and S. Makino, Severe Acute Respiratory Syndrome Coronavirus 7a Accessory Protein Is a Viral Structural Protein, Journal of Virology, vol.80, issue.15, pp.80-7287, 2006.
DOI : 10.1128/JVI.00414-06

C. Huang, C. J. Peters, and S. Makino, Severe Acute Respiratory Syndrome Coronavirus Accessory Protein 6 Is a Virion-Associated Protein and Is Released from 6 Protein-Expressing Cells, Journal of Virology, vol.81, issue.10, pp.81-5423, 2007.
DOI : 10.1128/JVI.02307-06

S. Pfefferle, V. Krahling, V. Ditt, K. Grywna, E. Muhlberger et al., Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo, Virology Journal, vol.6, issue.1, 2009.
DOI : 10.1186/1743-422X-6-131

C. Y. Chen, Y. H. Ping, H. C. Lee, K. H. Chen, Y. M. Lee et al., Open Reading Frame 8a of the Human Severe Acute Respiratory Syndrome Coronavirus Not Only Promotes Viral Replication but Also Induces Apoptosis, The Journal of Infectious Diseases, vol.196, issue.3, pp.405-415, 2007.
DOI : 10.1086/519166

J. Zhao, A. Falcon, H. Zhou, J. Netland, L. Enjuanes et al., Severe Acute Respiratory Syndrome Coronavirus Protein 6 Is Required for Optimal Replication, Journal of Virology, vol.83, issue.5, p.83, 2009.
DOI : 10.1128/JVI.02371-08

B. J. Haijema, H. Volders, and P. J. Rottier, Live, Attenuated Coronavirus Vaccines through the Directed Deletion of Group-Specific Genes Provide Protection against Feline Infectious Peritonitis, Journal of Virology, vol.78, issue.8, pp.78-3863, 2004.
DOI : 10.1128/JVI.78.8.3863-3871.2004

C. A. De-haan, P. S. Masters, X. Shen, S. Weiss, and P. J. Rottier, The Group-Specific Murine Coronavirus Genes Are Not Essential, but Their Deletion, by Reverse Genetics, Is Attenuating in the Natural Host, Virology, vol.296, issue.1, pp.177-189, 2002.
DOI : 10.1006/viro.2002.1412

S. K. Lau, P. C. Woo, K. S. Li, Y. Huang, H. W. Tsoi et al., Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats, Proc. Natl. Acad. Sci. U S A, pp.14040-14045, 2005.
DOI : 10.1073/pnas.0506735102

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236580

S. M. Chinese, Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China, Science, vol.303, pp.1666-1669, 2004.

W. Chan, K. F. Lim, K. Y. Shortridge, J. S. Yuen, L. L. Peiris et al., Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China, Science, vol.302, pp.276-278, 2003.

W. Li, Z. Shi, M. Yu, W. Ren, C. Smith et al., Bats Are Natural Reservoirs of SARS-Like Coronaviruses, Bats are natural reservoirs of SARS-like coronaviruses, pp.676-679, 2005.
DOI : 10.1126/science.1118391

B. Kan, M. Wang, H. Jing, H. Xu, X. Jiang et al., Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms, J. Virol, p.79, 2005.

T. M. Le, H. H. Wong, F. P. Tay, S. Fang, C. T. Keng et al., Expression, post-translational modification and biochemical characterization of proteins encoded by subgenomic mRNA8 of the severe acute respiratory syndrome coronavirus, FEBS Journal, vol.34, issue.16, pp.4211-4222, 2007.
DOI : 10.1111/j.1742-4658.2007.05947.x

M. Oostra, C. A. De-haan, and P. J. Rottier, The 29-Nucleotide Deletion Present in Human but Not in Animal Severe Acute Respiratory Syndrome Coronaviruses Disrupts the Functional Expression of Open Reading Frame 8, Journal of Virology, vol.81, issue.24, p.81, 2007.
DOI : 10.1128/JVI.01631-07

S. C. Sung, C. Y. Chao, K. S. Jeng, J. Y. Yang, and M. M. Lai, The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6, Virology, vol.387, issue.2, 2009.
DOI : 10.1016/j.virol.2009.02.021

P. Y. Law, Y. M. Liu, H. Geng, K. H. Kwan, M. M. Waye et al., Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome-associated coronavirus, FEBS Letters, vol.331, issue.15, pp.3643-3648, 2006.
DOI : 10.1016/j.febslet.2006.05.051

C. T. Keng, Y. W. Choi, M. R. Welkers, D. Z. Chan, S. Shen et al., The human severe acute respiratory syndrome coronavirus (SARS-CoV) 8b protein is distinct from its counterpart in animal SARS-CoV and down-regulates the expression of the envelope protein in infected cells, Virology, vol.354, issue.1, pp.132-142, 2006.
DOI : 10.1016/j.virol.2006.06.026

A. Hershko and A. Ciechanover, THE UBIQUITIN SYSTEM, Annual Review of Biochemistry, vol.67, issue.1, pp.425-479, 1998.
DOI : 10.1146/annurev.biochem.67.1.425

L. Banks, D. Pim, and M. Thomas, Viruses and the 26S proteasome: hacking into destruction, Trends in Biochemical Sciences, vol.28, issue.8, pp.452-459, 2003.
DOI : 10.1016/S0968-0004(03)00141-5

K. D. Wilkinson, Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome, Seminars in Cell & Developmental Biology, vol.11, issue.3, pp.141-148, 2000.
DOI : 10.1006/scdb.2000.0164

A. Ciechanover and R. Ben-saadon, N-terminal ubiquitination: more protein substrates join in, Trends in Cell Biology, vol.14, issue.3, 2004.
DOI : 10.1016/j.tcb.2004.01.004

Y. J. Tan, P. Y. Goh, B. C. Fielding, S. Shen, C. F. Chou et al., Profiles of Antibody Responses against Severe Acute Respiratory Syndrome Coronavirus Recombinant Proteins and Their Potential Use as Diagnostic Markers, Clinical and Vaccine Immunology, vol.11, issue.2, pp.362-371, 2004.
DOI : 10.1128/CDLI.11.2.362-371.2004

C. T. Keng, A. Zhang, S. Shen, K. M. Lip, B. C. Fielding et al., Amino Acids 1055 to 1192 in the S2 Region of Severe Acute Respiratory Syndrome Coronavirus S Protein Induce Neutralizing Antibodies: Implications for the Development of Vaccines and Antiviral Agents, Journal of Virology, vol.79, issue.6, pp.79-3289, 2005.
DOI : 10.1128/JVI.79.6.3289-3296.2005

S. Akerstrom, M. Mousavi-jazi, J. Klingstrom, M. Leijon, A. Lundkvist et al., Nitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus, Journal of Virology, vol.79, issue.3, p.79, 2005.
DOI : 10.1128/JVI.79.3.1966-1969.2005

B. Nal, C. Chan, F. Kien, L. Siu, J. Tse et al., Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E, Journal of General Virology, vol.86, issue.5, pp.1423-1434, 2005.
DOI : 10.1099/vir.0.80671-0

V. C. Cheng, S. K. Lau, P. C. Woo, and K. Y. Yuen, Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection, Clinical Microbiology Reviews, vol.20, issue.4, pp.660-694, 2007.
DOI : 10.1128/CMR.00023-07

D. Vijaykrishna, G. J. Smith, J. X. Zhang, J. S. Peiris, H. Chen et al., Evolutionary insights into the ecology of coronaviruses, J. Virol, pp.81-4012, 2007.

M. Guo, H. Y. Pan, W. Z. He, J. C. Manuguerra, A. Fontanet et al., Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human, Proc. Natl. Acad. Sci. U S A, pp.2430-2435, 2005.

E. Domingo, C. Escarmis, N. Sevilla, A. Moya, S. F. Elena et al., Basic concepts in RNA virus evolution, FASEB J, pp.10-859, 1996.

M. Orlowski and S. Wilk, Ubiquitin-independent proteolytic functions of the proteasome, Archives of Biochemistry and Biophysics, vol.415, issue.1, pp.415-416, 2003.
DOI : 10.1016/S0003-9861(03)00197-8

J. M. Baugh, E. G. Viktorova, and E. V. Pilipenko, Proteasomes Can Degrade a Significant Proportion of Cellular Proteins Independent of Ubiquitination, Journal of Molecular Biology, vol.386, issue.3, pp.386-814, 2009.
DOI : 10.1016/j.jmb.2008.12.081

M. L. Dediego, E. Alvarez, F. Almazan, M. T. Rejas, E. Lamirande et al., A Severe Acute Respiratory Syndrome Coronavirus That Lacks the E Gene Is Attenuated In Vitro and In Vivo, Journal of Virology, vol.81, issue.4, pp.81-1701, 2007.
DOI : 10.1128/JVI.01467-06

M. L. Dediego, L. Pewe, E. Alvarez, M. T. Rejas, S. Perlman et al., Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice, Virology, vol.376, issue.2, pp.379-389, 2008.
DOI : 10.1016/j.virol.2008.03.005

M. T. Vossen, E. M. Westerhout, C. Soderberg-naucler, and E. J. Wiertz, Viral immune evasion: a masterpiece of evolution, Immunogenetics, vol.54, issue.8, pp.527-542, 2002.
DOI : 10.1007/s00251-002-0493-1

S. Bonhoeffer and P. Sniegowski, Virus evolution: The importance of being erroneous, Nature, vol.347, issue.6914, pp.367-369, 2002.
DOI : 10.1073/pnas.111085598