J. Peiris, M. De-jong, and Y. Guan, Avian Influenza Virus (H5N1): a Threat to Human Health, Clinical Microbiology Reviews, vol.20, issue.2, pp.243-267, 2007.
DOI : 10.1128/CMR.00037-06

URL : https://hal.archives-ouvertes.fr/pasteur-00589027

M. Michaelis, H. Doerr, J. Cinatl, and J. , Novel swine-origin influenza A virus in humans: another pandemic knocking at the door, Medical Microbiology and Immunology, vol.52, issue.3, 2009.
DOI : 10.1007/s00430-009-0118-5

R. Garten, C. Davis, C. Russell, B. Shu, and S. Lindstrom, Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans, Science, vol.325, issue.5937, pp.197-201, 2009.
DOI : 10.1126/science.1176225

G. Smith, D. Vijaykrishna, J. Bahl, S. Lycett, and M. Worobey, Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic, Nature, vol.22, issue.7250, pp.1122-1125, 2009.
DOI : 10.1038/nature08182

J. Koen, A practical method for field diagnoses of swine diseases, Am J Vet Med, vol.14, pp.468-470, 1919.

R. Takano, C. Nidom, M. Kiso, Y. Muramoto, and S. Yamada, A comparison of the pathogenicity of avian and swine H5N1 influenza viruses in Indonesia, Archives of Virology, vol.204, issue.4, pp.677-681, 2009.
DOI : 10.1007/s00705-009-0353-5

M. Jong, C. Simmons, T. Thanh, V. Hien, and G. Smith, Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia, Nature Medicine, vol.99, issue.10, pp.1203-1207, 2006.
DOI : 10.1038/nm1477

R. Salomon, E. Hoffmann, and R. Webster, Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection, Proceedings of the National Academy of Sciences, vol.104, issue.30, pp.12479-12481, 2007.
DOI : 10.1073/pnas.0705289104

J. Peiris, W. Yu, C. Leung, C. Cheung, and W. Ng, Re-emergence of fatal human influenza A subtype H5N1 disease, The Lancet, vol.363, issue.9409, pp.617-619, 2004.
DOI : 10.1016/S0140-6736(04)15595-5

C. Baskin, H. Bielefeldt-ohmann, T. Tumpey, P. Sabourin, and J. Long, Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus, Proceedings of the National Academy of Sciences, vol.106, issue.9, pp.3455-3460, 2009.
DOI : 10.1073/pnas.0813234106

L. Perrone, J. Plowden, A. Garcia-sastre, J. Katz, and T. Tumpey, H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice, PLoS Pathogens, vol.10, issue.652, p.1000115, 2008.
DOI : 10.1371/journal.ppat.1000115.t002

L. Zitzow, T. Rowe, T. Morken, W. Shieh, and S. Zaki, Pathogenesis of Avian Influenza A (H5N1) Viruses in Ferrets, Journal of Virology, vol.76, issue.9, pp.4420-4429, 2002.
DOI : 10.1128/JVI.76.9.4420-4429.2002

M. Chan, C. Cheung, W. Chui, S. Tsao, and J. Nicholls, Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells, Respiratory Research, vol.431, issue.21, p.135, 2005.
DOI : 10.1038/nature02951

C. Cheung, L. Poon, A. Lau, W. Luk, and Y. Lau, Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?, The Lancet, vol.360, issue.9348, pp.1831-1837, 2002.
DOI : 10.1016/S0140-6736(02)11772-7

S. Lee, C. Cheung, J. Nicholls, K. Hui, and C. Leung, Hyperinduction of Cyclooxygenase???2???Mediated Proinflammatory Cascade: A Mechanism for the Pathogenesis of Avian Influenza H5N1 Infection, The Journal of Infectious Diseases, vol.198, issue.4, pp.525-535, 2008.
DOI : 10.1086/590499

URL : https://hal.archives-ouvertes.fr/pasteur-00588953

J. Nicholls, M. Chan, W. Chan, H. Wong, and C. Cheung, Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine, vol.312, issue.2, pp.147-149, 2007.
DOI : 10.1038/nm1529

D. Lynn, G. Winsor, C. Chan, N. Richard, and M. Laird, InnateDB: facilitating systems-level analyses of the mammalian innate immune response, Molecular Systems Biology, vol.36, p.218, 2008.
DOI : 10.1038/ni1087

S. Samarajiwa, S. Forster, K. Auchettl, and P. Hertzog, INTERFEROME: the database of interferon regulated genes, Nucleic Acids Research, vol.37, issue.Database, pp.852-857, 2009.
DOI : 10.1093/nar/gkn732

P. Shannon, A. Markiel, O. Ozier, N. Baliga, and J. Wang, Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks, Genome Research, vol.13, issue.11, pp.2498-2504, 2003.
DOI : 10.1101/gr.1239303

K. Mok, C. Wong, C. Cheung, M. Chan, and S. Lee, Viral Genetic Determinants of H5N1 Influenza Viruses That Contribute to Cytokine Dysregulation, The Journal of Infectious Diseases, vol.200, issue.7, 2009.
DOI : 10.1086/605606

URL : https://hal.archives-ouvertes.fr/pasteur-00588919

Z. He, J. Jiang, M. Kokkinaki, N. Golestaneh, and M. Hofmann, Gdnf Upregulates c-Fos Transcription via the Ras/Erk1/2 Pathway to Promote Mouse Spermatogonial Stem Cell Proliferation, Stem Cells, vol.121, issue.1, pp.266-278, 2008.
DOI : 10.1634/stemcells.2007-0436

K. Horsch, H. De-wet, M. Schuurmans, A. , F. Cato et al., Mitogen-Activated Protein Kinase Phosphatase 1/Dual Specificity Phosphatase 1 Mediates Glucocorticoid Inhibition of Osteoblast Proliferation, Molecular Endocrinology, vol.21, issue.12, pp.2929-2940, 2007.
DOI : 10.1210/me.2007-0153

B. Teunissen, P. Smeets, P. Willemsen, D. Windt, L. Van-der-vusse et al., Activation of PPAR?? inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts, Cardiovascular Research, vol.75, issue.3, pp.519-529, 2007.
DOI : 10.1016/j.cardiores.2007.04.026

J. Gatot, R. Gioia, T. Chau, F. Patrascu, and M. Warnier, Lipopolysaccharide-mediated Interferon Regulatory Factor Activation Involves TBK1-IKK??-dependent Lys63-linked Polyubiquitination and Phosphorylation of TANK/I-TRAF, Journal of Biological Chemistry, vol.282, issue.43, pp.31131-31146, 2007.
DOI : 10.1074/jbc.M701690200

G. Uze and D. Monneron, IL-28 and IL-29: Newcomers to the interferon family, Biochimie, vol.89, issue.6-7, pp.729-734, 2007.
DOI : 10.1016/j.biochi.2007.01.008

W. Alexander, R. Starr, D. Metcalf, S. Nicholson, and A. Farley, Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction, J Leukoc Biol, vol.66, pp.588-592, 1999.

M. Chong, A. Cornish, R. Darwiche, E. Stanley, and J. Purton, Suppressor of Cytokine Signaling-1 Is a Critical Regulator of Interleukin-7-Dependent CD8+ T Cell Differentiation, Immunity, vol.18, issue.4, pp.475-487, 2003.
DOI : 10.1016/S1074-7613(03)00078-5

S. Gingras, E. Parganas, A. De-pauw, J. Ihle, and P. Murray, Re-examination of the Role of Suppressor of Cytokine Signaling 1 (SOCS1) in the Regulation of Toll-like Receptor Signaling, Journal of Biological Chemistry, vol.279, issue.52, pp.54702-54707, 2004.
DOI : 10.1074/jbc.M411043200

I. Kinjyo, T. Hanada, K. Inagaki-ohara, H. Mori, and D. Aki, SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation, Immunity, vol.17, issue.5, pp.583-591, 2002.
DOI : 10.1016/S1074-7613(02)00446-6

A. Mansell, R. Smith, S. Doyle, P. Gray, and J. Fenner, Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation, Nature Immunology, vol.166, issue.2, pp.148-155, 2006.
DOI : 10.1038/ni1299

J. Pothlichet, M. Chignard, and M. Si-tahar, Cutting Edge: Innate Immune Response Triggered by Influenza A Virus Is Negatively Regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-Dependent Pathway, The Journal of Immunology, vol.180, issue.4, pp.2034-2038, 2008.
DOI : 10.4049/jimmunol.180.4.2034

URL : https://hal.archives-ouvertes.fr/pasteur-00206322

M. Chae, K. Kim, S. Park, I. Jang, and T. Seo, IRF-2 regulates NFkappaB activity by modulating the subcellular localization of NF-kappaB, 2008.

R. Billharz, H. Zeng, S. Proll, M. Korth, and S. Lederer, The NS1 Protein of the 1918 Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism Pathways, Journal of Virology, vol.83, issue.20, 2009.
DOI : 10.1128/JVI.00330-09

E. Bartee and G. Mcfadden, Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-??, Cytokine, vol.47, issue.3, pp.199-205, 2009.
DOI : 10.1016/j.cyto.2009.06.006

A. Yarilina, K. Park-min, T. Antoniv, X. Hu, and L. Ivashkiv, TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon???response genes, Nature Immunology, vol.181, issue.4, pp.378-387, 2008.
DOI : 10.1038/ni1576

K. Clark, L. Plater, P. M. Cohen, and P. , Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and I??B Kinase ??: A DISTINCT UPSTREAM KINASE MEDIATES SER-172 PHOSPHORYLATION AND ACTIVATION, Journal of Biological Chemistry, vol.284, issue.21, pp.14136-14146, 2009.
DOI : 10.1074/jbc.M109.000414

E. Oda, R. Ohki, H. Murasawa, J. Nemoto, and T. Shibue, Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis, Science, vol.288, issue.5468, pp.1053-1058, 2000.
DOI : 10.1126/science.288.5468.1053

A. Sesto, M. Navarro, F. Burslem, and J. Jorcano, Analysis of the ultraviolet B response in primary human keratinocytes using oligonucleotide microarrays, Proceedings of the National Academy of Sciences, vol.99, issue.5, pp.2965-2970, 2002.
DOI : 10.1073/pnas.052678999

D. Goubau, R. Romieu-mourez, M. Solis, E. Hernandez, and T. Mesplede, Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7, European Journal of Immunology, vol.37, issue.2, pp.527-540, 2009.
DOI : 10.1002/eji.200838832

E. Cheng, M. Wei, S. Weiler, R. Flavell, and T. Mak, BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis, Molecular Cell, vol.8, issue.3, pp.705-711, 2001.
DOI : 10.1016/S1097-2765(01)00320-3

URL : http://doi.org/10.1016/s1097-2765(01)00320-3

Q. Wei, G. Marchler, K. Edington, I. Karsch-mizrachi, and B. Paterson, RNA Interference Demonstrates a Role for nautilus in the Myogenic Conversion of Schneider Cells by daughterless, Developmental Biology, vol.228, issue.2, pp.239-255, 2000.
DOI : 10.1006/dbio.2000.9938

M. Kalai, V. Loo, G. , V. Berghe, T. Meeus et al., Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA, Cell Death and Differentiation, vol.93, issue.9, pp.981-994, 2002.
DOI : 10.1038/sj.cdd.4401051

C. Mok, D. Lee, C. Cheung, M. Peiris, and A. Lau, Differential onset of apoptosis in influenza A virus H5N1- and H1N1-infected human blood macrophages, Journal of General Virology, vol.88, issue.4, pp.1275-1280, 2007.
DOI : 10.1099/vir.0.82423-0

C. Cameron, M. Cameron, J. Bermejo-martin, L. Ran, and L. Xu, Gene Expression Analysis of Host Innate Immune Responses during Lethal H5N1 Infection in Ferrets, Journal of Virology, vol.82, issue.22, pp.11308-11317, 2008.
DOI : 10.1128/JVI.00691-08