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Analytical sensitivity of rapid influenza antigen detection tests for swine-origin influenza virus (H1N1).

Abstract : BACKGROUND: A novel swine origin influenza virus (S-OIV) (H1N1) is spreading worldwide and threatens to become pandemic. OBJECTIVES: Determine analytical sensitivity of selected commercially available rapid influenza antigen detection tests in detecting S-OIV H1N1. STUDY DESIGN: Serial dilutions of two S-OIV isolates, one seasonal influenza A (H1N1) isolate and a nasopharyngeal aspirate from a patient with S-OIV disease were tested in five commercially available influenza antigen detection tests and by virus isolation in cell culture. Viral M gene copy number was determined by quantitative PCR methods. RESULTS: The analytical sensitivity of the five influenza antigen detection tests for S-OIV (tissue culture infectious dose 50 (TCID(50)) log(10)3.3-4.7 was comparable with that of seasonal influenza (TCID(50) log(10)4.0-4.5). CONCLUSION: The analytical sensitivity of the selected influenza A antigen detection tests for detection of S-IOV was comparable with that of seasonal influenza H1N1.
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Submitted on : Wednesday, April 27, 2011 - 10:04:48 AM
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K. H. Chan, S. T. Lai, L. L. M. Poon, Y. Guan, K. Y. Yuen, et al.. Analytical sensitivity of rapid influenza antigen detection tests for swine-origin influenza virus (H1N1).. Journal of Clinical Virology, Elsevier, 2009, 45 (3), pp.205-7. ⟨10.1016/j.jcv.2009.05.034⟩. ⟨pasteur-00588942⟩

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