Smallpox vaccine safety is dependent on T cells and not B cells. - Archive ouverte HAL Access content directly
Journal Articles Journal of Infectious Diseases Year : 2011

Smallpox vaccine safety is dependent on T cells and not B cells.

(1) , (1) , (1) , (2) , (1) , (1) , (3) , (4) , (5) , (6) , (6) , (7) , (8) , (8) , (8) , (8) , (1)
1
2
3
4
5
6
7
8
Jean-Michel Heraud

Abstract

(See the editorial commentary by Bray, on pages 1037-9.) The licensed smallpox vaccine, ACAM2000, is a cell culture derivative of Dryvax. Both ACAM2000 and Dryvax are administered by skin scarification and can cause progressive vaccinia, with skin lesions that disseminate to distal sites. We have investigated the immunologic basis of the containment of vaccinia in the skin with the goal to identify safer vaccines for smallpox. Macaques were depleted systemically of T or B cells and vaccinated with either Dryvax or an attenuated vaccinia vaccine, LC16m8. B cell depletion did not affect the size of skin lesions induced by either vaccine. However, while depletion of both CD4(+) and CD8(+) T cells had no adverse effects on LC16m8-vaccinated animals, it caused progressive vaccinia in macaques immunized with Dryvax. As both Dryvax and LC16m8 vaccines protect healthy macaques from a lethal monkeypox intravenous challenge, our data identify LC16m8 as a safer and effective alternative to ACAM2000 and Dryvax vaccines for immunocompromised individuals.
Fichier principal
Vignette du fichier
LC16m8_JID_2011.pdf (879.31 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

pasteur-00589392 , version 1 (08-10-2011)

Identifiers

Cite

Shari N Gordon, Valentina Cecchinato, Vibeke Andresen, Jean-Michel Heraud, Anna Hryniewicz, et al.. Smallpox vaccine safety is dependent on T cells and not B cells.. Journal of Infectious Diseases, 2011, 203 (8), pp.1043-53. ⟨10.1093/infdis/jiq162⟩. ⟨pasteur-00589392⟩
125 View
631 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More