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Differences in the salivary effects of wild-caught versus colonized Phlebotomus papatasi (Diptera: Psychodidae) on the development of zoonotic cutaneous leishmaniasis in BALB/c mice.

Abstract : Preimmunization of mice with salivary gland homogenate (SGH) of long-term colonized (F29) female Phlebotomus papatasi Scopoli (Diptera: Psychodidae) induced protection against Leishmania major Yakimoff & Schokhor (Kinetoplastida: Trypanosomatidae) co-inoculated with the same type of SGH. In contrast, preimmunization of mice with SGH of wild-caught female P. papatasi did not confer protection against L. major co-inoculated with the same type of SGH. Similarly, SGH from recently colonized (F1) female P. papatasi did not protect mice against L. major. These results suggest that when developing a sand fly saliva-based vaccine, the natural vector populations should be considered.
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https://hal-riip.archives-ouvertes.fr/pasteur-00604860
Contributor : Hichem Ben Hassine <>
Submitted on : Wednesday, June 29, 2011 - 7:01:10 PM
Last modification on : Thursday, October 24, 2019 - 11:07:19 AM

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S. Ben Hadj Ahmed, I. Chelbi, B. Kaabi, S. Cherni, M. Derbali, et al.. Differences in the salivary effects of wild-caught versus colonized Phlebotomus papatasi (Diptera: Psychodidae) on the development of zoonotic cutaneous leishmaniasis in BALB/c mice.. Journal of Medical Entomology, Entomological Society of America, 2010, 47 (1), pp.74-79. ⟨10.1093/jmedent/47.1.74⟩. ⟨pasteur-00604860⟩

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