Differences in the salivary effects of wild-caught versus colonized Phlebotomus papatasi (Diptera: Psychodidae) on the development of zoonotic cutaneous leishmaniasis in BALB/c mice.

Abstract : Preimmunization of mice with salivary gland homogenate (SGH) of long-term colonized (F29) female Phlebotomus papatasi Scopoli (Diptera: Psychodidae) induced protection against Leishmania major Yakimoff & Schokhor (Kinetoplastida: Trypanosomatidae) co-inoculated with the same type of SGH. In contrast, preimmunization of mice with SGH of wild-caught female P. papatasi did not confer protection against L. major co-inoculated with the same type of SGH. Similarly, SGH from recently colonized (F1) female P. papatasi did not protect mice against L. major. These results suggest that when developing a sand fly saliva-based vaccine, the natural vector populations should be considered.
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https://hal-riip.archives-ouvertes.fr/pasteur-00604860
Contributor : Hichem Ben Hassine <>
Submitted on : Wednesday, June 29, 2011 - 7:01:10 PM
Last modification on : Monday, April 29, 2019 - 6:02:05 PM

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  • HAL Id : pasteur-00604860, version 1
  • PUBMED : 20180311

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S. Ben Hadj Ahmed, I. Chelbi, B. Kaabi, S. Cherni, M. Derbali, et al.. Differences in the salivary effects of wild-caught versus colonized Phlebotomus papatasi (Diptera: Psychodidae) on the development of zoonotic cutaneous leishmaniasis in BALB/c mice.. Journal of Medical Entomology, Entomological Society of America, 2010, 47 (1), pp.74-9. ⟨pasteur-00604860⟩

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