Age- Matched Comparison of Children Hospitalized for 2009 Pandemic H1N1 Influenza with Those Hospitalized for Seasonal H1N1 and H3N2.

Susan S. Chiu 1, * Kwok-Hung Chan 2 Wilfred H. S. Wong 1 Eunice L. Y. Chan 1 J. S. M. Peiris 2, 3
* Corresponding author
1 Department of Paediatrics and Adolescent Medicine [HKU]
2 Department of Microbiology [HKU]
3 Centre de recherche Université de Hong-Kong-Pasteur
Abstract : BACKGROUND: A wide spectrum of clinical manifestation ranging from deaths to a mild course of disease has been reported in children infected with the 2009 pandemic H1N1 (pH1N1) influenza. METHODOLOGY/MAJOR FINDINGS: We conducted an age-matched control study comparing children hospitalized for pH1N1 with historic controls infected with seasonal H1N1 and H3N2 influenza to correct for the effect of age on disease susceptibility and clinical manifestations. We also compared children with pH1N1 to children concurrently admitted for seasonal influenza during the pandemic period to adjust for differences in health-seeking behavior during the pandemic or other potential bias associated with historic controls. There was no death or intensive care admission. Children with pH1N1 were more likely to have at least one risk condition for influenza, an underlying chronic pulmonary condition, more likely to have asthma exacerbation and to be treated with oseltamivir. There was no difference in other aspects of the clinical course or outcome. CONCLUSION: Disease manifestation of children hospitalized for pH1N1 infection was mild in our patient population.
Document type :
Journal articles
Complete list of metadatas

Cited literature [24 references]  Display  Hide  Download
https://hal-riip.archives-ouvertes.fr/pasteur-00614345
Contributor : Francois Kien <>
Submitted on : Thursday, August 11, 2011 - 5:33:05 PM
Last modification on : Thursday, July 11, 2019 - 2:10:06 PM
Long-term archiving on : Saturday, November 12, 2011 - 2:20:55 AM

File

journal.pone.0021837.pdf
Publisher files allowed on an open archive

Identifiers

Collections

RIIP | RIIP_HONGKONG

Citation

Susan S. Chiu, Kwok-Hung Chan, Wilfred H. S. Wong, Eunice L. Y. Chan, J. S. M. Peiris. Age- Matched Comparison of Children Hospitalized for 2009 Pandemic H1N1 Influenza with Those Hospitalized for Seasonal H1N1 and H3N2.. PLoS ONE, Public Library of Science, 2011, 6 (7), pp.e21837. ⟨10.1371/journal.pone.0021837⟩. ⟨pasteur-00614345⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

237

Files downloads

206

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD