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A novel depolarizing activity of scorpion venom fraction M1 due to activation of skeletal muscle nicotinic receptors.

Abstract : A depolarizing activity following interaction with nicotinic acetylcholine receptors (nAchRs) in skeletal muscle cells, was observed for the first time in the non-toxic venom fraction (M1) of the yellow scorpion Buthus occitanus tunetanus (Bot). The effects of M1 fraction were tested on cultured rat myotubes by recording changes in [Ca2+]i. When applied, M1 (10 microg/mL) induced a transient increase of [Ca2+]i which could be blocked by a prior application of alpha-Bungarotoxin (alpha-Bg-Tx).
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https://hal-riip.archives-ouvertes.fr/pasteur-00614376
Contributor : Institut Pasteur Tunis <>
Submitted on : Thursday, August 11, 2011 - 9:41:58 AM
Last modification on : Wednesday, May 22, 2019 - 9:34:01 AM

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Amani Cheikh, Rym Benkhalifa, Daniel Potreau, Guy Raymond, Mohamed El Ayeb, et al.. A novel depolarizing activity of scorpion venom fraction M1 due to activation of skeletal muscle nicotinic receptors.. Toxicon, Elsevier, 2007, 49 (1), pp.117-22. ⟨10.1016/j.toxicon.2006.09.011⟩. ⟨pasteur-00614376⟩

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