A. V. Paul, E. Rieder, D. W. Kim, J. H. Van-boom, and E. Wimmer, Identification of an RNA Hairpin in Poliovirus RNA That Serves as the Primary Template in the In Vitro Uridylylation of VPg, Journal of Virology, vol.74, issue.22, pp.74-10359, 2000.
DOI : 10.1128/JVI.74.22.10359-10370.2000

B. A. Brown, M. S. Oberste, J. P. , A. Jr, M. L. Kennett et al., Molecular epidemiology and evolution of enterovirus 71 strains isolated from, J. Virol, pp.73-9969, 1970.

M. J. Cardosa, D. Perera, B. A. Brown, D. Cheon, H. M. Chan et al., Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes, Emerging Infectious Diseases, vol.9, issue.4, pp.461-468, 2003.
DOI : 10.3201/eid0904.020395

P. Mcminn, K. Lindsay, D. Perera, H. M. Chan, K. P. Chan et al., Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, J. Virol, pp.75-7732, 2001.

P. V. Tu, N. T. Thao, D. Perera, T. K. Huu, N. T. Tien et al., Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, Emerg. Infect. Dis, vol.13, pp.1733-1741, 2005.

K. Mizuta, C. Abiko, T. Murata, Y. Matsuzaki, T. Itagaki et al., Frequent importation of enterovirus 71 from surrounding countries into the local community of Yamagata, J. Clin. Microbiol, pp.43-6171, 1998.

P. C. Mcminn, An overview of the evolution of enterovirus 71 and its clinical and public health significance, FEMS Microbiology Reviews, vol.26, issue.1, pp.91-107, 2002.
DOI : 10.1111/j.1574-6976.2002.tb00601.x

S. Abubakar, H. Y. Chee, N. Shafee, K. B. Chua, and S. K. Lam, Molecular detection of enteroviruses from an outbreak of hand, foot and mouth disease in Malaysia in 1997, Scand, J. Infect. Dis, pp.31-331, 1999.

M. Ho, E. R. Chen, K. H. Hsu, S. J. Twu, K. T. Chen et al., An Epidemic of Enterovirus 71 Infection in Taiwan, New England Journal of Medicine, vol.341, issue.13, pp.341-929, 1999.
DOI : 10.1056/NEJM199909233411301

C. Y. Lu, C. Y. Lee, C. L. Kao, W. Y. Shao, P. I. Lee et al., Incidence and case-fatality rates resulting from the 1998 enterovirus 71 outbreak in Taiwan, Journal of Medical Virology, vol.5, issue.2, pp.67-217, 2002.
DOI : 10.1002/jmv.2210

L. Y. Chang, Enterovirus 71 in Taiwan, Pediatrics & Neonatology, vol.49, issue.4, pp.103-112, 2008.
DOI : 10.1016/S1875-9572(08)60023-6

C. C. Huang, C. C. Liu, Y. C. Chang, C. Y. Chen, S. T. Wang et al., Neurologic Complications in Children with Enterovirus 71 Infection, New England Journal of Medicine, vol.341, issue.13, pp.341-936, 1999.
DOI : 10.1056/NEJM199909233411302

H. Komatsu, Y. Shimizu, Y. Takeuchi, H. Ishiko, and H. Takada, Outbreak of severe neurologic involvement associated with enterovirus 71 infection, Pediatric Neurology, vol.20, issue.1, pp.17-23, 1999.
DOI : 10.1016/S0887-8994(98)00087-3

L. C. Lum, K. T. Wong, S. K. Lam, K. B. Chua, A. Y. Goh et al., Fatal enterovirus 71 encephalomyelitis, The Journal of Pediatrics, vol.133, issue.6, pp.133-795, 1998.
DOI : 10.1016/S0022-3476(98)70155-6

S. M. Wang, C. C. Liu, H. W. Tseng, J. R. Wang, C. C. Huang et al., Clinical Spectrum of Enterovirus 71 Infection in Children in Southern Taiwan, with an Emphasis on Neurological Complications, Clinical Infectious Diseases, vol.29, issue.1, pp.29-184, 1999.
DOI : 10.1086/520149

H. Song, S. Shih, Y. L. , and H. Zhuang, Advances in the study of enterovirus 71 infection, J. Pathogen Biol, vol.3, pp.947-949, 2008.

F. Yang, L. Ren, Z. Xiong, J. Li, Y. Xiao et al., Enterovirus 71 outbreak in the People's Republic of China, J. Clin. Microbiol, pp.47-2351, 2008.

Y. Zhang, X. J. Tan, H. Y. Wang, D. M. Yan, S. L. Zhu et al., An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China, Journal of Clinical Virology, vol.44, issue.4, pp.44-262, 2009.
DOI : 10.1016/j.jcv.2009.02.002

J. H. Chern, K. S. Shia, T. A. Hsu, C. L. Tai, C. C. Lee et al., Design, synthesis, and structure???activity relationships of pyrazolo[3,4-d]pyrimidines: a novel class of potent enterovirus inhibitors, Bioorganic & Medicinal Chemistry Letters, vol.14, issue.10, pp.2519-2525, 2004.
DOI : 10.1016/j.bmcl.2004.02.092

T. C. Chen, H. Y. Chang, P. F. Lin, J. H. Chern, J. T. Hsu et al., Novel Antiviral Agent DTriP-22 Targets RNA-Dependent RNA Polymerase of Enterovirus 71, Antimicrobial Agents and Chemotherapy, vol.53, issue.7, pp.2740-2747, 2009.
DOI : 10.1128/AAC.00101-09

Y. Wu, L. Z. , Y. Miao, Y. Yu, D. H. et al., Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China, Protein & Cell, vol.283, issue.5, pp.491-500, 2010.
DOI : 10.1007/s13238-010-0061-7

J. M. Bible, P. Pantelidis, P. K. Chan, and C. Y. Tong, Genetic evolution of enterovirus 71: epidemiological and pathological implications, Reviews in Medical Virology, vol.12, issue.6, pp.371-379, 2007.
DOI : 10.1002/rmv.538

M. Arita, H. Shimizu, N. Nagata, Y. Ami, Y. Suzaki et al., Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys, Journal of General Virology, vol.86, issue.5, pp.86-1391, 2005.
DOI : 10.1099/vir.0.80784-0

A. Murayama, L. Weng, T. Date, D. Akazawa, X. Tian et al., RNA Polymerase Activity and Specific RNA Structure Are Required for Efficient HCV Replication in Cultured Cells, PLoS Pathogens, vol.274, issue.12, p.1000885, 2010.
DOI : 10.1371/journal.ppat.1000885.s005

URL : https://hal.archives-ouvertes.fr/pasteur-00624881

J. J. Arnold and C. E. Cameron, Poliovirus RNA-dependent RNA polymerase (3D(pol)) Assembly of stable, elongation-competent complexes by using a symmetrical primer-template substrate (sym/sub, J. Biol. Chem, pp.275-5329, 2000.

L. Weng, J. Du, J. Zhou, J. Ding, T. Wakita et al., Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain, Archives of Virology, vol.74, issue.5, pp.765-773, 2009.
DOI : 10.1007/s00705-009-0366-0

URL : https://hal.archives-ouvertes.fr/pasteur-00625244

M. S. Oberste and J. B. Flanegan, Measurement of poliovirus RNA polymerase binding to poliovirion and nonviral RNAs using a filter-binding assay, Nucleic Acids Research, vol.16, issue.21, pp.10339-10352, 1988.
DOI : 10.1093/nar/16.21.10339

M. Kobayashi, T. Toyoda, and A. Ishihama, Influenza virus PB1 protein is the minimal and essential subunit of RNA polymerase, Archives of Virology, vol.88, issue.3-4, pp.525-539, 1996.
DOI : 10.1007/BF01718315

G. Luo, R. K. Hamatake, D. M. Mathis, J. Racela, K. L. Rigat et al., De Novo Initiation of RNA Synthesis by the RNA-Dependent RNA Polymerase (NS5B) of Hepatitis C Virus, Journal of Virology, vol.74, issue.2, pp.74-851, 2000.
DOI : 10.1128/JVI.74.2.851-863.2000

J. J. Arnold and C. E. Cameron, Poliovirus RNA-dependent RNA polymerase (3Dpol) is sufficient for template switching in vitro, J. Biol. Chem, pp.274-2706, 1999.

T. A. Steitz, DNA Polymerases: Structural Diversity and Common Mechanisms, Journal of Biological Chemistry, vol.274, issue.25, pp.17395-17398, 1999.
DOI : 10.1074/jbc.274.25.17395

C. Ferrer-orta, A. Arias, C. Escarmis, and N. Verdaguer, A comparison of viral RNA-dependent RNA polymerases, Current Opinion in Structural Biology, vol.16, issue.1, pp.27-34, 2006.
DOI : 10.1016/j.sbi.2005.12.002

C. A. Brautigam and T. A. Steitz, Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes, Current Opinion in Structural Biology, vol.8, issue.1, pp.54-63, 1998.
DOI : 10.1016/S0959-440X(98)80010-9

A. Arias, J. J. Arnold, M. Sierra, E. D. Smidansky, E. Domingo et al., Determinants of RNA-Dependent RNA Polymerase (In)fidelity Revealed by Kinetic Analysis of the Polymerase Encoded by a Foot-and-Mouth Disease Virus Mutant with Reduced Sensitivity to Ribavirin, Journal of Virology, vol.82, issue.24, pp.82-12346, 2008.
DOI : 10.1128/JVI.01297-08

M. Hung, C. S. Gibbs, and M. Tsiang, Biochemical characterization of rhinovirus RNA-dependent RNA polymerase, Antiviral Research, vol.56, issue.2, pp.99-114, 2002.
DOI : 10.1016/S0166-3542(02)00101-8

A. Gruez, B. Selisko, M. Roberts, G. Bricogne, C. Bussetta et al., The Crystal Structure of Coxsackievirus B3 RNA-Dependent RNA Polymerase in Complex with Its Protein Primer VPg Confirms the Existence of a Second VPg Binding Site on Picornaviridae Polymerases, Journal of Virology, vol.82, issue.19, pp.9577-9590, 2008.
DOI : 10.1128/JVI.00631-08

G. Campagnola, M. Weygandt, K. Scoggin, and O. Peersen, Crystal Structure of Coxsackievirus B3 3Dpol Highlights the Functional Importance of Residue 5 in Picornavirus Polymerases, Journal of Virology, vol.82, issue.19, pp.9458-9464, 2008.
DOI : 10.1128/JVI.00647-08

S. Tabor and C. C. Richardson, Effect of manganese ions on the incorporation of dideoxynucleotides by bacteriophage T7 DNA polymerase and Escherichia coli DNA polymerase I., Proceedings of the National Academy of Sciences, vol.86, issue.11, pp.86-4076, 1989.
DOI : 10.1073/pnas.86.11.4076

A. Palmenberg and P. Kaesberg, Synthesis of complementary strands of heterologous RNAs with Qbeta replicase, Proc. Natl. Acad. Sci. U. S. A, pp.71-1371, 1974.

A. Romani, Regulation of magnesium homeostasis and transport in mammalian cells, Archives of Biochemistry and Biophysics, vol.458, issue.1, pp.90-102, 2007.
DOI : 10.1016/j.abb.2006.07.012

M. Morello, A. Canini, P. Mattioli, R. P. Sorge, A. Alimonti et al., Sub-cellular localization of manganese in the basal ganglia of normal and manganese-treated rats, NeuroToxicology, vol.29, issue.1, pp.60-72, 2008.
DOI : 10.1016/j.neuro.2007.09.001

K. Kalia, W. Jiang, and W. Zheng, Manganese accumulates primarily in nuclei of cultured brain cells, NeuroToxicology, vol.29, issue.3, pp.466-470, 2008.
DOI : 10.1016/j.neuro.2008.02.012

D. W. Gohara, S. Crotty, J. J. Arnold, J. D. Yoder, R. Andino et al., Poliovirus RNAdependent RNA polymerase (3Dpol): structural, biochemical, and biological analysis of conserved structural motifs A and B, J. Biol. Chem, pp.275-25523, 2000.

X. Chen, Q. Zhang, J. Li, W. Cao, J. X. Zhang et al., Analysis of recombination and natural selection in human enterovirus 71, Virology, vol.398, issue.2, pp.251-261, 2010.
DOI : 10.1016/j.virol.2009.12.007

N. Z. Ding, X. M. Wang, S. W. Sun, Q. Song, S. N. Li et al., Appearance of mosaic enterovirus 71 in the 2008 outbreak of China, Virus Research, vol.145, issue.1, 2009.
DOI : 10.1016/j.virusres.2009.06.006

S. C. Huang, Y. W. Hsu, H. C. Wang, S. W. Huang, D. Kiang et al., Appearance of intratypic recombination of enterovirus 71 in Taiwan from 2002 to 2005, Virus Research, vol.131, issue.2, pp.250-259, 2002.
DOI : 10.1016/j.virusres.2007.10.002

Y. Zhang, Z. Zhu, W. Yang, J. Ren, X. Tan et al., An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of Hand Foot and Mouth Disease in Fuyang city of China, An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of Hand Foot and Mouth Disease in Fuyang city of China, p.94, 2010.
DOI : 10.1186/1743-422X-7-94

A. Arias, R. Agudo, C. Ferrer-orta, R. Perez-luque, A. Airaksinen et al., Mutant Viral Polymerase in the Transition of Virus to Error Catastrophe Identifies a Critical Site for RNA Binding, Journal of Molecular Biology, vol.353, issue.5, pp.353-1021, 2005.
DOI : 10.1016/j.jmb.2005.09.022

J. D. Pata, S. C. Schultz, and K. Kirkegaard, Functional oligomerization of poliovirus RNAdependent RNA polymerase, RNA, vol.1, pp.466-477, 1995.

N. and L. Novere, MELTING, computing the melting temperature of nucleic acid duplex, Bioinformatics, vol.17, issue.12, pp.17-1226, 2001.
DOI : 10.1093/bioinformatics/17.12.1226

K. L. Neufeld, J. M. Galarza, O. C. Richards, D. F. Summers, and E. Ehrenfeld, Identification of terminal adenylyl transferase activity of the poliovirus polymerase 3Dpol, J. Virol, pp.68-5811, 1994.

J. L. Hansen, A. M. Long, and S. C. Schultz, Structure of the RNA-dependent RNA polymerase of poliovirus, Structure, vol.5, issue.8, pp.1109-1122, 1997.
DOI : 10.1016/S0969-2126(97)00261-X

M. T. Beckman and K. Kirkegaard, Site Size of Cooperative Single-stranded RNA Binding by Poliovirus RNA-dependent RNA Polymerase, Journal of Biological Chemistry, vol.273, issue.12, pp.6724-6730, 1998.
DOI : 10.1074/jbc.273.12.6724

S. Zhang, L. Weng, L. Geng, J. Wang, J. Zhou et al., Biochemical and kinetic analysis of the influenza virus RNA polymerase purified from insect cells, Biochemical and Biophysical Research Communications, vol.391, issue.1, pp.391-570, 2010.
DOI : 10.1016/j.bbrc.2009.11.100

URL : https://hal.archives-ouvertes.fr/pasteur-00624863

J. J. Arnold, S. K. Ghosh, and C. E. Cameron, Poliovirus RNA-dependent RNA polymerase (3D(pol)). Divalent cation modulation of primer, template, and nucleotide selection, J. Biol. Chem, pp.274-37060, 1999.

Z. H. Li, C. M. Li, P. Ling, F. H. Shen, S. H. Chen et al., Ribavirin Reduces Mortality in Enterovirus 71???Infected Mice by Decreasing Viral Replication, The Journal of Infectious Diseases, vol.197, issue.6, pp.854-857, 2008.
DOI : 10.1086/527326

A. V. Paul, X. Cao, K. S. Harris, J. Lama, and E. Wimmer, Studies with poliovirus polymerase 3Dpol. Stimulation of poly(U) synthesis in vitro by purified poliovirus protein 3AB, J. Biol. Chem, pp.269-29173, 1994.