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Epidemiologic and clinical features of cutaneous leishmaniasis in southeastern Tunisia.

Abstract : Species-specific diagnosis was performed in 66 patients with cutaneous leishmaniasis (CL) living in Tataouine focus in southeastern Tunisia. Leishmania DNA was extracted directly from dermal scrapings (n = 66) and from parasites obtained in culture (n = 12). Species were identified by using polymerase chain reaction-restriction fragment length polymorphism analysis for internal transcribed spacer region 1 and isoenzyme analysis. Leishmania tropica and L. major were identified in 31 (47%) and 35 (53%) cases respectively. Leishmania tropica CL cases were geographically scattered, and L. major CL cases were clustered. Lesions caused by L. tropica were mostly single (83.8%) and face-localized (55.8%), and lesions caused by L. major were multiple (57.1%; P < 0.001) and situated on limbs (83.7%; P < 0.001). For both species, most lesion onsets were reported during June-January. However, lesions that emerged during February-May were mainly caused by L. tropica (83.3%; P < 0.01). Moreover, the delay before seeking medical advice was higher for L. tropica infections than for L. major infections (P < 0.05).
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Submitted on : Friday, September 23, 2011 - 6:22:30 PM
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Nadia Bousslimi, Karim Aoun, Imène Ben-Abda, Nissaf Ben-Alaya-Bouafif, Mohamed Raouane, et al.. Epidemiologic and clinical features of cutaneous leishmaniasis in southeastern Tunisia.. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2010, 83 (5), pp.1034-9. ⟨10.4269/ajtmh.2010.10-0234⟩. ⟨pasteur-00620980⟩



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