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[Dysfibrinogenemia and thrombosis. A case report].

Abstract : BACKGROUND: Congenital dysfibrinogenemia is a functional disorder of the fibrinogen that represents a rare cause of thrombophilia. AIM: To report a Tunisian case of the association dysfibrinogenemia and thrombosis. CASE: A woman with inherited dysfibrinogenemia associated with mild tendency to bleeding experienced a deep vein thrombosis of the lower-extremity at 26 years of age and a fatal pulmonary embolism a few years later. Paradoxically coagulation function of fibrinogen was markedly altered in vitro with a significantly prolonged prothrombin time, activated partial thromboplastin time and thrombin time, a functional fibrinogen level that was undetected and a severely impaired fibrin polymerisation. The thromboembolic events in the patient could be related to dysfibrinogenemia since the main causes of thrombophilia were excluded. CONCLUSION: Although it is rare, this cause of thrombophilia must not be misdiagnosed, systematic measuring of prothrombin time, activated partial thromboplastin time and functional fibrinogen might be helpful.
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https://hal-riip.archives-ouvertes.fr/pasteur-00620986
Contributor : Institut Pasteur Tunis <>
Submitted on : Thursday, September 22, 2011 - 4:10:55 PM
Last modification on : Monday, October 8, 2018 - 5:44:07 PM

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  • HAL Id : pasteur-00620986, version 1
  • PUBMED : 20890827

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Imen Kraiem, Sami Guermazi, Héla Ben Abid, Balkis Meddeb. [Dysfibrinogenemia and thrombosis. A case report].. Tunisie Medicale, Maghreb-Editions; 1999, 2010, 88 (10), pp.757-60. ⟨pasteur-00620986⟩

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