Lack of protection of pre-immunization with saliva of long-term colonized Phlebotomus papatasi against experimental challenge with Leishmania major and saliva of wild-caught P. papatasi.

Sami Ben Hadj Ahmed; Belhassen Kaabi; Ifhem Chelbi; Mohamed Derbali; Saifedine Cherni; Dhafer Laouini; Elyes Zhioua

Lack of protection of pre-immunization with saliva of long-term colonized Phlebotomus papatasi against experimental challenge with Leishmania major and saliva of wild-caught P. papatasi.

Sami Ben Hadj Ahmed ^{1, 2} Belhassen Kaabi ¹ Ifhem Chelbi ¹ Mohamed Derbali ¹ Saifedine Cherni ¹ Dhafer Laouini ¹ Elyes Zhioua ^{1, *}

* Corresponding author

1 Institut Pasteur de Tunis

2 Department of Biology

Abstract : Immunity to saliva of Phlebotomus papatasi protects against Leishmania major infection as determined by co-inoculation of parasites with salivary gland homogenates (SGHs) of this vector. These results were obtained with long-term colonized female P. papatasi. We investigated the effect of pre-immunization with SGH of long-term colonized P. papatasi against L. major infection co-inoculated with SGH of wild-caught P. papatasi. Our results showed that pre-exposure to SGH of long-term, colonized P. papatasi do not confer protection against infection with L. major co-inoculated with SGH of wild-caught P. papatasi. These preliminary results strongly suggest that the effectiveness of a vector saliva-based vaccine derived from colonized sand fly populations may be affected by inconsistent immune response after natural exposure.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Microbiology and Parasitology

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https://hal-riip.archives-ouvertes.fr/pasteur-00620991
Contributor : Institut Pasteur Tunis <>
Submitted on : Thursday, September 22, 2011 - 3:51:47 PM
Last modification on : Monday, April 29, 2019 - 5:48:03 PM

Lack of protection of pre-immunization with saliva of long-term colonized Phlebotomus papatasi against experimental challenge with Leishmania major and saliva of wild-caught P. papatasi.

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Lack of protection of pre-immunization with saliva of long-term colonized Phlebotomus papatasi against experimental challenge with Leishmania major and saliva of wild-caught P. papatasi.

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