Lack of protection of pre-immunization with saliva of long-term colonized Phlebotomus papatasi against experimental challenge with Leishmania major and saliva of wild-caught P. papatasi.

Sami Ben Hadj Ahmed 1, 2 Belhassen Kaabi 1 Ifhem Chelbi 1 Mohamed Derbali 1 Saifedine Cherni 1 Dhafer Laouini 1 Elyes Zhioua 1, *
* Corresponding author
1 Institut Pasteur de Tunis
2 Department of Biology
Abstract : Immunity to saliva of Phlebotomus papatasi protects against Leishmania major infection as determined by co-inoculation of parasites with salivary gland homogenates (SGHs) of this vector. These results were obtained with long-term colonized female P. papatasi. We investigated the effect of pre-immunization with SGH of long-term colonized P. papatasi against L. major infection co-inoculated with SGH of wild-caught P. papatasi. Our results showed that pre-exposure to SGH of long-term, colonized P. papatasi do not confer protection against infection with L. major co-inoculated with SGH of wild-caught P. papatasi. These preliminary results strongly suggest that the effectiveness of a vector saliva-based vaccine derived from colonized sand fly populations may be affected by inconsistent immune response after natural exposure.
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Submitted on : Thursday, September 22, 2011 - 3:51:47 PM
Last modification on : Monday, April 29, 2019 - 5:48:03 PM

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Sami Ben Hadj Ahmed, Belhassen Kaabi, Ifhem Chelbi, Mohamed Derbali, Saifedine Cherni, et al.. Lack of protection of pre-immunization with saliva of long-term colonized Phlebotomus papatasi against experimental challenge with Leishmania major and saliva of wild-caught P. papatasi.. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2010, 83 (3), pp.512-4. ⟨10.4269/ajtmh.2010.09-0687⟩. ⟨pasteur-00620991⟩

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