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Journal articles
Lack of protection of pre-immunization with saliva of long-term colonized Phlebotomus papatasi against experimental challenge with Leishmania major and saliva of wild-caught P. papatasi.
Abstract : Immunity to saliva of Phlebotomus papatasi protects against Leishmania major infection as determined by co-inoculation of parasites with salivary gland homogenates (SGHs) of this vector. These results were obtained with long-term colonized female P. papatasi. We investigated the effect of pre-immunization with SGH of long-term colonized P. papatasi against L. major infection co-inoculated with SGH of wild-caught P. papatasi. Our results showed that pre-exposure to SGH of long-term, colonized P. papatasi do not confer protection against infection with L. major co-inoculated with SGH of wild-caught P. papatasi. These preliminary results strongly suggest that the effectiveness of a vector saliva-based vaccine derived from colonized sand fly populations may be affected by inconsistent immune response after natural exposure.
https://hal-riip.archives-ouvertes.fr/pasteur-00620991
Contributor : Institut Pasteur Tunis Connect in order to contact the contributor
Submitted on : Thursday, September 22, 2011 - 3:51:47 PM
Last modification on : Monday, April 29, 2019 - 5:48:03 PM
Contributor : Institut Pasteur Tunis Connect in order to contact the contributor
Submitted on : Thursday, September 22, 2011 - 3:51:47 PM
Last modification on : Monday, April 29, 2019 - 5:48:03 PM
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