Identification of two novel variants in PRKAG2 gene in Tunisian type 2 diabetic patients with family history of cardiovascular disease.

S. Nouira (1, 2) , I. Arfa (1) , Imen Kmmoun.I (2) , A. Abid (3) , H. Ouragini (1) , I. Dorboz (1) , W. Ghazouani (1) , S. Ben Fadhel (1) , M. M. Zorgati (1) , S. Ben Ammar (1) , S. Blousa-Chabchoub , S. Kachboura (2) , S. Abdelhak (1)

1 Institut Pasteur de Tunis
2 Unit UR 09/04, Cardiology Department,
3 National Institute of Nutrition,

We report the identification of two novel polymorphisms in the PRKAG2 gene and preliminary association study between 5'-UTR and exon 1 polymorphisms with susceptibility to type 2 diabetes. No association with type 2 diabetes was identified. However, one of these newly identified polymorphisms (p.Ser20Ile) is likely associated with cardiac disease.

S. Nouira, I. Arfa, Imen Kmmoun.I, A. Abid, H. Ouragini, et al.. Identification of two novel variants in PRKAG2 gene in Tunisian type 2 diabetic patients with family history of cardiovascular disease.. Diabetes Research and Clinical Practice, 2010, 87 (2), pp.e7-10. ⟨10.1016/j.diabres.2009.11.009⟩. ⟨pasteur-00621006⟩