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Les Métalloprotéases des venins de serpents: structure, biosynthèse et fonction(s)

Abstract : The biochemical and the pharmacological characterization of snake venoms revealed an important structural and functional polymorphism of proteins which they contain. Among them, snake venom metalloproteases (SVMPs) constitute approximatively 20 to 60% of the whole venom proteins. During the last decades, a significant progress was performed against structure studies and the biosynthesis of the SVMPs. Indeed, several metalloproteases were isolated and characterized against their structural and pharmacological properties. In this review, we report the most important properties concerning the classification, the structure of the various domains of the SVMPs as well as their biosynthesis and their activities as potential therapeutic agents.
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https://hal-riip.archives-ouvertes.fr/pasteur-00621020
Contributor : Institut Pasteur Tunis <>
Submitted on : Friday, September 9, 2011 - 11:45:04 AM
Last modification on : Friday, November 29, 2019 - 10:43:29 AM

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  • HAL Id : pasteur-00621020, version 1
  • PUBMED : 21604456

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I. Limam, M. El Ayeb, N. Marrakchi. Les Métalloprotéases des venins de serpents: structure, biosynthèse et fonction(s). Archives de l'Institut Pasteur de Tunis, 2010, 87 (1-2), pp.3-15. ⟨pasteur-00621020⟩

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