S. Lemon, C. Walker, M. Alter, and M. Yi, Hepatitis C virus, Fields Virology 5 ed. PhiladelphiaPA: Lippincott-Raven Publishers, pp.1253-1304, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00441475

A. Wasley and M. Alter, Epidemiology of Hepatitis C: Geographic Differences and Temporal Trends, Seminars in Liver Disease, vol.20, issue.Number 01, pp.1-16, 2000.
DOI : 10.1055/s-2000-9506

A. Grakoui, C. Wychowski, C. Lin, S. Feinstone, and C. Rice, Expression and identification of hepatitis C virus polyprotein cleavage products, J Virol, vol.67, pp.1385-1395, 1993.

M. Hijikata, H. Mizushima, Y. Tanji, Y. Komoda, and Y. Hirowatari, Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus., Proceedings of the National Academy of Sciences, vol.90, issue.22, pp.10773-10777, 1993.
DOI : 10.1073/pnas.90.22.10773

K. Tsukiyama-kohara, N. Iizuka, M. Kohara, and A. Nomoto, Internal ribosome entry site within hepatitis C virus RNA, J Virol, vol.66, pp.1476-1483, 1992.

T. Tanaka, N. Kato, M. Cho, and K. Shimotohno, A Novel Sequence Found at the 3???-Terminus of Hepatitis C Virus Genome, Biochemical and Biophysical Research Communications, vol.215, issue.2, pp.744-749, 1995.
DOI : 10.1006/bbrc.1995.2526

S. You, D. Stump, A. Branch, and C. Rice, A cis-Acting Replication Element in the Sequence Encoding the NS5B RNA-Dependent RNA Polymerase Is Required for Hepatitis C Virus RNA Replication, Journal of Virology, vol.78, issue.3, pp.1352-1366, 2004.
DOI : 10.1128/JVI.78.3.1352-1366.2004

T. Wakita, T. Pietschmann, T. Kato, T. Date, and M. Miyamoto, Production of infectious hepatitis C virus in tissue culture from a cloned viral genome, Nature Medicine, vol.37, issue.7, pp.791-796, 2005.
DOI : 10.1002/jmv.10297

J. Zhong, P. Gastaminza, G. Cheng, S. Kapadia, and T. Kato, Robust hepatitis C virus infection in vitro, Proceedings of the National Academy of Sciences, vol.102, issue.26, pp.9294-9299, 2005.
DOI : 10.1073/pnas.0503596102

B. Lindenbach, M. Evans, A. Syder, B. Wolk, and T. Tellinghuisen, Complete Replication of Hepatitis C Virus in Cell Culture, Science, vol.309, issue.5734, pp.623-626, 2005.
DOI : 10.1126/science.1114016

T. Pietschmann, A. Kaul, G. Koutsoudakis, A. Shavinskaya, and S. Kallis, Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras, Proceedings of the National Academy of Sciences, vol.103, issue.19, pp.7408-7413, 2006.
DOI : 10.1073/pnas.0504877103

A. Murayama, T. Date, K. Morikawa, D. Akazawa, and M. Miyamoto, The NS3 Helicase and NS5B-to-3'X Regions Are Important for Efficient Hepatitis C Virus Strain JFH-1 Replication in Huh7 Cells, Journal of Virology, vol.81, issue.15, pp.8030-8040, 2007.
DOI : 10.1128/JVI.02088-06

L. Weng, J. Du, J. Zhou, J. Ding, and T. Wakita, Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain, Archives of Virology, vol.74, issue.5, pp.765-773, 2009.
DOI : 10.1007/s00705-009-0366-0

URL : https://hal.archives-ouvertes.fr/pasteur-00625244

P. Friebe and R. Bartenschlager, Genetic Analysis of Sequences in the 3' Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication, Journal of Virology, vol.76, issue.11, pp.5326-5338, 2002.
DOI : 10.1128/JVI.76.11.5326-5338.2002

M. Yanagi, R. Purcell, S. Emerson, and J. Bukh, Hepatitis C Virus: An Infectious Molecular Clone of a Second Major Genotype (2a) and Lack of Viability of Intertypic 1a and 2a Chimeras, Virology, vol.262, issue.1, pp.250-263, 1999.
DOI : 10.1006/viro.1999.9889

S. You and C. Rice, 3' RNA Elements in Hepatitis C Virus Replication: Kissing Partners and Long Poly(U), Journal of Virology, vol.82, issue.1, pp.184-195, 2008.
DOI : 10.1128/JVI.01796-07

H. Nakabayashi, K. Taketa, K. Miyano, T. Yamane, and J. Sato, Growth of human hepatoma cells lines with differentiated functions in chemically defined medium, Cancer Res, vol.42, pp.3858-3863, 1982.

C. Kuiken, C. Combet, J. Bukh, I. Shin, and G. Deleage, A comprehensive system for consistent numbering of HCV sequences, proteins and epitopes, Hepatology, vol.4, issue.5, pp.1355-1361, 2006.
DOI : 10.1002/hep.21377

URL : https://hal.archives-ouvertes.fr/hal-00314898

M. Van-den-hoff, A. Moorman, and W. Lamers, Electroporation in ???intracellular??? buffer increases cell survival, Nucleic Acids Research, vol.20, issue.11, p.2902, 1992.
DOI : 10.1093/nar/20.11.2902

T. Kato, T. Date, M. Miyamoto, M. Sugiyama, and Y. Tanaka, Detection of Anti-Hepatitis C Virus Effects of Interferon and Ribavirin by a Sensitive Replicon System, Journal of Clinical Microbiology, vol.43, issue.11, pp.5679-5684, 2005.
DOI : 10.1128/JCM.43.11.5679-5684.2005

M. Zuker, Mfold web server for nucleic acid folding and hybridization prediction, Nucleic Acids Research, vol.31, issue.13, pp.3406-3415, 2003.
DOI : 10.1093/nar/gkg595

URL : http://doi.org/10.1093/nar/gkg595

P. Friebe, J. Boudet, J. Simorre, and R. Bartenschlager, Kissing-Loop Interaction in the 3' End of the Hepatitis C Virus Genome Essential for RNA Replication, Journal of Virology, vol.79, issue.1, pp.380-392, 2005.
DOI : 10.1128/JVI.79.1.380-392.2005

V. Leveque, R. Johnson, S. Parsons, J. Ren, and C. Xie, Identification of a C-Terminal Regulatory Motif in Hepatitis C Virus RNA-Dependent RNA Polymerase: Structural and Biochemical Analysis, Journal of Virology, vol.77, issue.16, pp.9020-9028, 2003.
DOI : 10.1128/JVI.77.16.9020-9028.2003

W. Zhong, E. Ferrari, C. Lesburg, D. Maag, and S. Ghosh, Template/Primer Requirements and Single Nucleotide Incorporation by Hepatitis C Virus Nonstructural Protein 5B Polymerase, Journal of Virology, vol.74, issue.19, pp.9134-9143, 2000.
DOI : 10.1128/JVI.74.19.9134-9143.2000

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC102112

Z. Hong, C. Cameron, M. Walker, C. Castro, and N. Yao, A Novel Mechanism to Ensure Terminal Initiation by Hepatitis C Virus NS5B Polymerase, Virology, vol.285, issue.1, pp.6-11, 2001.
DOI : 10.1006/viro.2001.0948

P. Simister, M. Schmitt, M. Geitmann, O. Wicht, and U. Danielson, Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase, Journal of Virology, vol.83, issue.22, 2009.
DOI : 10.1128/JVI.01008-09

Z. Cai, M. Yi, C. Zhang, and G. Luo, Mutagenesis Analysis of the rGTP-Specific Binding Site of Hepatitis C Virus RNA-Dependent RNA Polymerase, Journal of Virology, vol.79, issue.18, pp.11607-11617, 2005.
DOI : 10.1128/JVI.79.18.11607-11617.2005

V. Arumugaswami, R. Remenyi, V. Kanagavel, E. Sue, N. Ho et al., High-Resolution Functional Profiling of Hepatitis C Virus Genome, PLoS Pathogens, vol.72, issue.10, 2008.
DOI : 10.1371/journal.ppat.1000182.s010

A. Kanai, K. Tanabe, and M. Kohara, Poly(U) binding activity of hepatitis C virus NS3 protein, a putative RNA helicase, FEBS Letters, vol.267, issue.3, pp.221-224, 1995.
DOI : 10.1016/0014-5793(95)01283-X

G. Luo, R. Hamatake, D. Mathis, J. Racela, and K. Rigat, De Novo Initiation of RNA Synthesis by the RNA-Dependent RNA Polymerase (NS5B) of Hepatitis C Virus, Journal of Virology, vol.74, issue.2, pp.851-863, 2000.
DOI : 10.1128/JVI.74.2.851-863.2000

L. Huang, J. Hwang, S. Sharma, M. Hargittai, and Y. Chen, Hepatitis C Virus Nonstructural Protein 5A (NS5A) Is an RNA-binding Protein, Journal of Biological Chemistry, vol.280, issue.43, pp.36417-36428, 2005.
DOI : 10.1074/jbc.M508175200

R. Gontarek, L. Gutshall, K. Herold, J. Tsai, and G. Sathe, hnRNP C and polypyrimidine tract-binding protein specifically interact with the pyrimidine-rich region within the 3'NTR of the HCV RNA genome, Nucleic Acids Research, vol.27, issue.6, pp.1457-1463, 1999.
DOI : 10.1093/nar/27.6.1457

G. Luo, Cellular Proteins Bind to the Poly(U) Tract of the 3??? Untranslated Region of Hepatitis C Virus RNA Genome, Virology, vol.256, issue.1, pp.105-118, 1999.
DOI : 10.1006/viro.1999.9639

J. Petrik, H. Parker, and G. Alexander, Human hepatic glyceraldehyde-3-phosphate dehydrogenase binds to the poly(U) tract of the 3??? non-coding region of hepatitis C virus genomic RNA, Journal of General Virology, vol.80, issue.12, pp.3109-3113, 1999.
DOI : 10.1099/0022-1317-80-12-3109

K. Spangberg, L. Wiklund, and S. Schwartz, Binding of the La autoantigen to the hepatitis C virus 3??? untranslated region protects the RNA from rapid degradation in vitro, Journal of General Virology, vol.82, issue.1, pp.113-120, 2001.
DOI : 10.1099/0022-1317-82-1-113

K. Spangberg, L. Wiklund, and S. Schwartz, HuR, a Protein Implicated in Oncogene and Growth Factor mRNA Decay, Binds to the 3??? Ends of Hepatitis C Virus RNA of Both Polarities, Virology, vol.274, issue.2, pp.378-390, 2000.
DOI : 10.1006/viro.2000.0461