N. J. Adams, R. W. Chamberlain, L. A. Taylor, F. Davidson, C. K. Lin et al., Complete Coding Sequence of Hepatitis C Virus Genotype 6a, Biochemical and Biophysical Research Communications, vol.234, issue.2, pp.393-396, 1997.
DOI : 10.1006/bbrc.1997.6627

H. Aizaki, K. J. Lee, V. M. Sung, H. Ishiko, and M. M. Lai, Characterization of the hepatitis C virus RNA replication complex associated with lipid rafts, Virology, vol.324, issue.2, pp.450-461, 2004.
DOI : 10.1016/j.virol.2004.03.034

H. Aizaki, K. Morikawa, M. Fukasawa, H. Hara, Y. Inoue et al., Critical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus Infection, Journal of Virology, vol.82, issue.12, pp.5715-5724, 2008.
DOI : 10.1128/JVI.02530-07

F. Amemiya, S. Maekawa, Y. Itakura, A. Kanayama, A. Matsui et al., Targeting Lipid Metabolism in the Treatment of Hepatitis C Virus Infection, The Journal of Infectious Diseases, vol.197, issue.3, pp.361-370, 2008.
DOI : 10.1086/525287

M. Binder, D. Quinkert, O. Bochkarova, R. Klein, N. Kezmic et al., Identification of Determinants Involved in Initiation of Hepatitis C Virus RNA Synthesis by Using Intergenotypic Replicase Chimeras, Journal of Virology, vol.81, issue.10, pp.5270-5283, 2007.
DOI : 10.1128/JVI.00032-07

B. K. Biswal, M. M. Cherney, M. Wang, L. Chan, C. G. Yannopoulos et al., Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors, Journal of Biological Chemistry, vol.280, issue.18, pp.18202-18210, 2005.
DOI : 10.1074/jbc.M413410200

K. J. Blight, J. A. Mckeating, J. Marcotrigiano, and C. M. Rice, Efficient Replication of Hepatitis C Virus Genotype 1a RNAs in Cell Culture, Journal of Virology, vol.77, issue.5, pp.3181-3190, 2003.
DOI : 10.1128/JVI.77.5.3181-3190.2003

R. W. Chamberlain, N. J. Adams, L. A. Taylor, P. Simmonds, and R. M. Elliott, The Complete Coding Sequence of Hepatitis C Virus Genotype 5a, the Predominant Genotype in South Africa, Biochemical and Biophysical Research Communications, vol.236, issue.1, pp.44-49, 1997.
DOI : 10.1006/bbrc.1997.6902

S. Chinnaswamy, I. Yarbrough, S. Palaninathan, C. T. Kumar, V. Vijayaraghavan et al., A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase, Journal of Biological Chemistry, vol.283, issue.29, pp.20535-20546, 2008.
DOI : 10.1074/jbc.M801490200

P. Y. Chou and G. D. Fasman, Prediction of protein conformation, Biochemistry, vol.13, issue.2, pp.222-245, 1974.
DOI : 10.1021/bi00699a002

T. Fujimoto, H. Kogo, K. Ishiguro, K. Tauchi, and R. Nomura, Caveolin-2 Is Targeted to Lipid Droplets, a New ???Membrane Domain??? in the Cell, The Journal of Cell Biology, vol.95, issue.5, pp.1079-1085, 2001.
DOI : 10.1016/S0005-2736(00)00294-7

J. M. Gottwein, T. K. Scheel, B. Callendret, Y. P. Li, H. B. Eccleston et al., Novel Infectious cDNA Clones of Hepatitis C Virus Genotype 3a (Strain S52) and 4a (Strain ED43): Genetic Analyses and In Vivo Pathogenesis Studies, Journal of Virology, vol.84, issue.10, pp.5277-5293
DOI : 10.1128/JVI.02667-09

D. Hammache, G. Pieroni, N. Yahi, O. Delezay, N. Koch et al., Specific Interaction of HIV-1 and HIV-2 Surface Envelope Glycoproteins with Monolayers of Galactosylceramide and Ganglioside GM3, Journal of Biological Chemistry, vol.273, issue.14, pp.7967-7971, 1998.
DOI : 10.1074/jbc.273.14.7967

J. Q. Hang, Y. Yang, S. F. Harris, V. Leveque, H. J. Whittington et al., Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus, Journal of Biological Chemistry, vol.284, issue.23, pp.15517-15529, 2009.
DOI : 10.1074/jbc.M808889200

H. Huang, F. Sun, D. M. Owen, W. Li, Y. Chen et al., Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins, Proceedings of the National Academy of Sciences, vol.104, issue.14, pp.5848-5853, 2007.
DOI : 10.1073/pnas.0700760104

N. Ishii, K. Watashi, T. Hishiki, K. Goto, D. Inoue et al., Diverse Effects of Cyclosporine on Hepatitis C Virus Strain Replication, Journal of Virology, vol.80, issue.9, pp.4510-4520, 2006.
DOI : 10.1128/JVI.80.9.4510-4520.2006

T. Kashiwagi, K. Hara, M. Kohara, K. Kohara, J. Iwahashi et al., Kinetic Analysis of C-Terminally Truncated RNA-Dependent RNA Polymerase of Hepatitis C Virus, Biochemical and Biophysical Research Communications, vol.290, issue.4, pp.1188-1194, 2002.
DOI : 10.1006/bbrc.2001.6333

T. Kato, T. Date, M. Miyamoto, A. Furusaka, K. Tokushige et al., Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon, Gastroenterology, vol.125, issue.6, pp.1808-1817, 2003.
DOI : 10.1053/j.gastro.2003.09.023

K. Kiyosawa, T. Sodeyama, E. Tanaka, Y. Gibo, K. Yoshizawa et al., Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: Analysis by detection of antibody to hepatitis C virus, Hepatology, vol.27, issue.4, pp.671-675, 1990.
DOI : 10.1002/hep.1840120409

M. Lambot, S. Fretier, A. Op-de-beeck, B. Quatannens, S. Lestavel et al., Reconstitution of Hepatitis C Virus Envelope Glycoproteins into Liposomes as a Surrogate Model to Study Virus Attachment, Journal of Biological Chemistry, vol.277, issue.23, pp.20625-20630, 2002.
DOI : 10.1074/jbc.M111020200

S. Lemon, C. Walker, M. Alter, and M. Yi, Hepatitis C virus, Fields virology, pp.1253-1304, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00441475

R. Mahfoud, N. Garmy, M. Maresca, N. Yahi, A. Puigserver et al., Identification of a Common Sphingolipid-binding Domain in Alzheimer, Prion, and HIV-1 Proteins, Journal of Biological Chemistry, vol.277, issue.13, pp.11292-11296, 2002.
DOI : 10.1074/jbc.M111679200

Y. Miyake, Y. Kozutsumi, S. Nakamura, T. Fujita, and T. Kawasaki, Serine Palmitoyltransferase Is the Primary Target of a Sphingosine-like Immunosuppressant, ISP-1/Myriocin, Biochemical and Biophysical Research Communications, vol.211, issue.2, pp.396-403, 1995.
DOI : 10.1006/bbrc.1995.1827

Y. Miyanari, K. Atsuzawa, N. Usuda, K. Watashi, T. Hishiki et al., The lipid droplet is an important organelle for hepatitis C virus production, Nature Cell Biology, vol.71, issue.9, pp.1089-1097, 2007.
DOI : 10.1007/s00418-005-0061-5

A. Murayama, T. Date, K. Morikawa, D. Akazawa, M. Miyamoto et al., The NS3 Helicase and NS5B-to-3'X Regions Are Important for Efficient Hepatitis C Virus Strain JFH-1 Replication in Huh7 Cells, Journal of Virology, vol.81, issue.15, pp.8030-8040, 2007.
DOI : 10.1128/JVI.02088-06

A. Murayama, L. Weng, T. Date, D. Akazawa, X. Tian et al., RNA Polymerase Activity and Specific RNA Structure Are Required for Efficient HCV Replication in Cultured Cells, PLoS Pathogens, vol.274, issue.12, p.1000885, 2010.
DOI : 10.1371/journal.ppat.1000885.s005

URL : https://hal.archives-ouvertes.fr/pasteur-00624881

A. G. Ostermeyer, J. M. Paci, Y. Zeng, D. M. Lublin, S. Munro et al., Accumulation of Caveolin in the Endoplasmic Reticulum Redirects the Protein to Lipid Storage Droplets, The Journal of Cell Biology, vol.19, issue.5, pp.1071-1078, 2001.
DOI : 10.1074/jbc.270.11.5772

I. Saito, T. Miyamura, A. Ohbayashi, H. Harada, T. Katayama et al., Hepatitis C virus infection is associated with the development of hepatocellular carcinoma., Proceedings of the National Academy of Sciences, vol.87, issue.17, pp.6547-6549, 1990.
DOI : 10.1073/pnas.87.17.6547

H. Sakamoto, K. Okamoto, M. Aoki, H. Kato, A. Katsume et al., Host sphingolipid biosynthesis as a target for hepatitis C virus therapy, Nature Chemical Biology, vol.228, issue.6, pp.333-337, 2005.
DOI : 10.1128/JVI.78.7.3480-3488.2004

S. T. Shi, K. J. Lee, H. Aizaki, S. B. Hwang, and M. M. Lai, Hepatitis C Virus RNA Replication Occurs on a Detergent-Resistant Membrane That Cofractionates with Caveolin-2, Journal of Virology, vol.77, issue.7, pp.4160-4168, 2003.
DOI : 10.1128/JVI.77.7.4160-4168.2003

P. Simister, M. Schmitt, M. Geitmann, O. Wicht, U. H. Danielson et al., Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase, Journal of Virology, vol.83, issue.22, pp.11926-11939, 2009.
DOI : 10.1128/JVI.01008-09

K. Tsukiyama-kohara, S. Tone, I. Maruyama, K. Inoue, A. Katsume et al., Activation of the CKI-CDK-Rb-E2F Pathway in Full Genome Hepatitis C Virus-expressing Cells, Journal of Biological Chemistry, vol.279, issue.15, pp.14531-14541, 2004.
DOI : 10.1074/jbc.M312822200

T. Umehara, M. Sudoh, F. Yasui, C. Matsuda, Y. Hayashi et al., Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model, Biochemical and Biophysical Research Communications, vol.346, issue.1, pp.67-73, 2006.
DOI : 10.1016/j.bbrc.2006.05.085

A. Wasley and M. J. Alter, Epidemiology of Hepatitis C: Geographic Differences and Temporal Trends, Seminars in Liver Disease, vol.20, issue.Number 01, pp.1-16, 2000.
DOI : 10.1055/s-2000-9506

K. Watashi, N. Ishii, M. Hijikata, D. Inoue, T. Murata et al., Cyclophilin B Is a Functional Regulator of Hepatitis C Virus RNA Polymerase, Molecular Cell, vol.19, issue.1, pp.111-122, 2005.
DOI : 10.1016/j.molcel.2005.05.014

L. Weng, J. Du, J. Zhou, J. Ding, T. Wakita et al., Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain, Archives of Virology, vol.74, issue.5, pp.765-773, 2009.
DOI : 10.1007/s00705-009-0366-0

URL : https://hal.archives-ouvertes.fr/pasteur-00625244

S. Yasuda, H. Kitagawa, M. Ueno, H. Ishitani, M. Fukasawa et al., A Novel Inhibitor of Ceramide Trafficking from the Endoplasmic Reticulum to the Site of Sphingomyelin Synthesis, Journal of Biological Chemistry, vol.276, issue.47, pp.43994-44002, 2001.
DOI : 10.1074/jbc.M104884200

J. Zhong, P. Gastaminza, G. Cheng, S. Kapadia, T. Kato et al., Robust hepatitis C virus infection in vitro, Proceedings of the National Academy of Sciences, vol.102, issue.26, pp.9294-9299, 2005.
DOI : 10.1073/pnas.0503596102