D. Bailey and P. O. Hare, Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease, Journal of General Virology, vol.83, issue.12, pp.2951-2964, 2002.
DOI : 10.1099/0022-1317-83-12-2951

J. K. Palese and . Taubenberger, Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes, Proc. Natl. Acad. Sci. U. S. A, vol.98, pp.2746-2751, 2001.

M. Bergmann, A. Garcia-sastre, E. Carnero, H. Pehamberger, K. Wolff et al., Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication, Journal of Virology, vol.74, issue.13, pp.6203-6206, 2000.
DOI : 10.1128/JVI.74.13.6203-6206.2000

R. Boggio and S. Chiocca, Viruses and sumoylation: recent highlights, Current Opinion in Microbiology, vol.9, issue.4, pp.430-436, 2006.
DOI : 10.1016/j.mib.2006.06.008

R. Boggio, R. Colombo, R. T. Hay, G. F. Draetta, and S. Chiocca, A Mechanism for Inhibiting the SUMO Pathway, Molecular Cell, vol.16, issue.4, pp.549-561, 2004.
DOI : 10.1016/j.molcel.2004.11.007

Z. A. Bornholdt and B. V. Prasad, X-ray structure of influenza virus NS1 effector domain, Nature Structural & Molecular Biology, vol.101, issue.6, pp.559-560, 2006.
DOI : 10.1038/nsmb1099

Z. Chen, Y. Li, and R. M. Krug, Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery, The EMBO Journal, vol.18, issue.8, pp.2273-2283, 1999.
DOI : 10.1093/emboj/18.8.2273

J. Cheng, X. Kang, S. Zhang, and E. T. Yeh, SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1?? during Hypoxia, Cell, vol.131, issue.3, pp.584-595, 2007.
DOI : 10.1016/j.cell.2007.08.045

E. C. Claas, Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus, The Lancet, vol.351, issue.9101, pp.472-477, 1998.
DOI : 10.1016/S0140-6736(97)11212-0

D. Jong, J. C. , E. C. Claas, A. D. Osterhaus, R. G. Webster et al., A pandemic warning, Nature, vol.389, issue.6651, p.554, 1997.
DOI : 10.1038/39218

W. G. Dundon and I. Capua, A Closer Look at the NS1 of Influenza Virus, Viruses, vol.1, issue.3, pp.1057-1072, 2009.
DOI : 10.3390/v1031057

R. A. Fouchier, V. Munster, A. Wallensten, T. M. Bestebroer, S. Herfst et al., Characterization of a Novel Influenza A Virus Hemagglutinin Subtype (H16) Obtained from Black-Headed Gulls, Journal of Virology, vol.79, issue.5, pp.2814-2822, 2005.
DOI : 10.1128/JVI.79.5.2814-2822.2005

C. Fraser, C. A. Donnelly, S. Cauchemez, W. P. Hanage, M. D. Van-kerkhove et al., Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings, Pandemic potential of a strain of influenza A (H1N1): early findings, pp.1557-1561, 2009.
DOI : 10.1126/science.1176062

A. Garcia-sastre, Inhibition of Interferon-Mediated Antiviral Responses by Influenza A Viruses and Other Negative-Strand RNA Viruses, Virology, vol.279, issue.2, pp.375-384, 2001.
DOI : 10.1006/viro.2000.0756

A. Garcia-sastre, A. Egorov, D. Matassov, S. Brandt, D. E. Levy et al., Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems, Virology, vol.252, issue.2, pp.324-330, 1998.
DOI : 10.1006/viro.1998.9508

R. Geiss-friedlander and F. Melchior, Concepts in sumoylation: a decade on, Nature Reviews Molecular Cell Biology, vol.1773, issue.12, pp.947-956, 2007.
DOI : 10.1038/nrm2293

G. Gill, Something about SUMO inhibits transcription, Current Opinion in Genetics & Development, vol.15, issue.5, pp.536-541, 2005.
DOI : 10.1016/j.gde.2005.07.004

G. Gill, SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? Genes Dev, pp.2046-2059, 2004.

D. W. Girdwood, M. H. Tatham, and R. T. Hay, SUMO and transcriptional regulation, Seminars in Cell & Developmental Biology, vol.15, issue.2, pp.201-210, 2004.
DOI : 10.1016/j.semcdb.2003.12.001

B. G. Hale, A. Knebel, C. H. Botting, C. S. Galloway, B. L. Precious et al., CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215, Virology, vol.383, issue.1, pp.6-11, 2009.
DOI : 10.1016/j.virol.2008.10.002

B. G. Hale, R. E. Randall, J. Ortin, and D. Jackson, The multifunctional NS1 protein of influenza A viruses, Journal of General Virology, vol.89, issue.10, pp.2359-2376, 2008.
DOI : 10.1099/vir.0.2008/004606-0

B. G. Hale, J. Steel, B. Manicassamy, R. A. Medina, J. Ye et al., Mutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus, Journal of General Virology, vol.91, issue.7, pp.1737-1742, 2010.
DOI : 10.1099/vir.0.020925-0

R. T. Hay, SUMO, Molecular Cell, vol.18, issue.1, pp.1-12, 2005.
DOI : 10.1016/j.molcel.2005.03.012
URL : https://hal.archives-ouvertes.fr/hal-00479165

L. S. Heikkinen, A. Kazlauskas, K. Melen, R. Wagner, T. Ziegler et al., Avian and 1918 Spanish Influenza A Virus NS1 Proteins Bind to Crk/CrkL Src Homology 3 Domains to Activate Host Cell Signaling, Journal of Biological Chemistry, vol.283, issue.9, pp.5719-5727, 2008.
DOI : 10.1074/jbc.M707195200

E. Hoffmann, G. Neumann, Y. Kawaoka, G. Hobom, and R. G. Webster, A DNA transfection system for generation of influenza A virus from eight plasmids, Proceedings of the National Academy of Sciences, vol.97, issue.11, pp.6108-6113, 2000.
DOI : 10.1073/pnas.100133697

E. Hoffmann, J. Stech, Y. Guan, R. G. Webster, and D. R. Perez, Universal primer set for the full-length amplification of all influenza A viruses, Archives of Virology, vol.146, issue.12, pp.2275-2289, 2001.
DOI : 10.1007/s007050170002

D. Jackson, M. J. Hossain, D. Hickman, D. R. Perez, and R. A. Lamb, A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity, Proceedings of the National Academy of Sciences, vol.105, issue.11, pp.4381-4386, 2008.
DOI : 10.1073/pnas.0800482105

M. J. Kim, I. V. Chia, and F. Costantini, SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability, The FASEB Journal, vol.22, issue.11, pp.3785-3794, 2008.
DOI : 10.1096/fj.08-113910

C. Klenk, J. Humrich, U. Quitterer, and M. J. Lohse, SUMO-1 Controls the Protein Stability and the Biological Function of Phosducin, Journal of Biological Chemistry, vol.281, issue.13, pp.8357-8364, 2006.
DOI : 10.1074/jbc.M513703200

G. Kochs, A. Garcia-sastre, and L. Martinez-sobrido, Multiple Anti-Interferon Actions of the Influenza A Virus NS1 Protein, Journal of Virology, vol.81, issue.13, pp.7011-7021, 2007.
DOI : 10.1128/JVI.02581-06

G. Kochs, I. Koerner, L. Thiel, S. Kothlow, B. Kaspers et al., Properties of H7N7 influenza A virus strain SC35M lacking interferon antagonist NS1 in mice and chickens, Journal of General Virology, vol.88, issue.5, pp.1403-1409, 2007.
DOI : 10.1099/vir.0.82764-0

R. Konig, S. Stertz, Y. Zhou, A. Inoue, H. H. Hoffmann et al., Human host factors required for influenza virus replication, Nature, vol.4, issue.7282, pp.813-817, 2010.
DOI : 10.1038/nature08699

H. R. Lee, D. J. Kim, J. M. Lee, C. Y. Choi, B. Y. Ahn et al., Ability of the Human Cytomegalovirus IE1 Protein To Modulate Sumoylation of PML Correlates with Its Functional Activities in Transcriptional Regulation and Infectivity in Cultured Fibroblast Cells, Journal of Virology, vol.78, issue.12, pp.6527-6542, 2004.
DOI : 10.1128/JVI.78.12.6527-6542.2004

S. Li, J. Y. Min, R. M. Krug, and G. C. Sen, Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA, Virology, vol.349, issue.1, pp.13-21, 2006.
DOI : 10.1016/j.virol.2006.01.005

K. Melen, L. Kinnunen, R. Fagerlund, N. Ikonen, K. Y. Twu et al., Nuclear and Nucleolar Targeting of Influenza A Virus NS1 Protein: Striking Differences between Different Virus Subtypes, Journal of Virology, vol.81, issue.11, pp.5995-6006, 2007.
DOI : 10.1128/JVI.01714-06

E. Meulmeester and F. Melchior, Cell biology: SUMO, Nature, vol.452, issue.7188, pp.709-711, 2008.
DOI : 10.1038/452709a

M. Mibayashi, L. Martinez-sobrido, Y. M. Loo, W. B. Cardenas, M. Gale et al., Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza A Virus, Journal of Virology, vol.81, issue.2, pp.514-524, 2007.
DOI : 10.1128/JVI.01265-06

J. Y. Min and R. M. Krug, The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway, Proceedings of the National Academy of Sciences, vol.103, issue.18, pp.7100-7105, 2006.
DOI : 10.1073/pnas.0602184103

J. Y. Min, S. Li, G. C. Sen, and R. M. Krug, A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis, Virology, vol.363, issue.1, pp.236-243, 2007.
DOI : 10.1016/j.virol.2007.01.038

D. Mukhopadhyay and M. Dasso, Modification in reverse: the SUMO proteases, Trends in Biochemical Sciences, vol.32, issue.6, pp.286-295, 2007.
DOI : 10.1016/j.tibs.2007.05.002

S. Muller, A. Ledl, and D. Schmidt, SUMO: a regulator of gene expression and genome integrity, Oncogene, vol.23, issue.11, pp.1998-2008, 2004.
DOI : 10.1038/sj.onc.1207415

M. E. Nemeroff, S. M. Barabino, Y. Li, W. Keller, and R. M. Krug, Influenza Virus NS1 Protein Interacts with the Cellular 30 kDa Subunit of CPSF and Inhibits 3??? End Formation of Cellular Pre-mRNAs, Molecular Cell, vol.1, issue.7, pp.991-1000, 1998.
DOI : 10.1016/S1097-2765(00)80099-4

C. M. Newby, L. Sabin, and A. Pekosz, The RNA Binding Domain of Influenza A Virus NS1 Protein Affects Secretion of Tumor Necrosis Factor Alpha, Interleukin-6, and Interferon in Primary Murine Tracheal Epithelial Cells, Journal of Virology, vol.81, issue.17, pp.9469-9480, 2007.
DOI : 10.1128/JVI.00989-07

D. L. Noah, K. Y. Twu, and R. M. Krug, Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3??? end processing of cellular pre-mRNAS, Virology, vol.307, issue.2, pp.386-395, 2003.
DOI : 10.1016/S0042-6822(02)00127-7

S. Pal, J. M. Rosas, and G. Rosas-acosta, Identification of the non-structural influenza A viral protein NS1A as a bona fide target of the Small Ubiquitin-like MOdifier by the use of dicistronic expression constructs, Journal of Virological Methods, vol.163, issue.2, pp.498-504, 2010.
DOI : 10.1016/j.jviromet.2009.11.010

M. L. Privalsky and E. E. Penhoet, The structure and synthesis of influenza virus phosphoproteins, J. Biol. Chem, vol.256, pp.5368-5376, 1981.

Y. Qiu, M. Nemeroff, and R. M. Krug, The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing, RNA, vol.1, pp.304-316, 1995.

D. Reverter and C. D. Lima, A Basis for SUMO Protease Specificity Provided by Analysis of Human Senp2 and a Senp2-SUMO Complex, Structure, vol.12, issue.8, pp.1519-1531, 2004.
DOI : 10.1016/j.str.2004.05.023

M. A. Rizzo, G. H. Springer, B. Granada, and D. W. Piston, An improved cyan fluorescent protein variant useful for FRET, Nature Biotechnology, vol.22, issue.4, pp.445-449, 2004.
DOI : 10.1038/nbt945

H. Saitoh and J. Hinchey, Functional Heterogeneity of Small Ubiquitin-related Protein Modifiers SUMO-1 versus SUMO-2/3, Journal of Biological Chemistry, vol.275, issue.9, pp.6252-6258, 2000.
DOI : 10.1074/jbc.275.9.6252

H. Saitoh, M. D. Pizzi, and J. Wang, Perturbation of SUMOlation, SUMO1 MODIFICATION OF INFLUENZA A VIRUS NS1 PROTEIN 1097, 2002.

N. Satterly, P. L. Tsai, J. Van-deursen, D. R. Nussenzveig, Y. Wang et al., Influenza virus targets the mRNA export machinery and the nuclear pore complex, Proceedings of the National Academy of Sciences, vol.104, issue.6, pp.1853-1858, 2007.
DOI : 10.1073/pnas.0610977104

J. S. Seeler and A. Dejean, Nuclear and unclear functions of SUMO, Nature Reviews Molecular Cell Biology, vol.4, issue.9, pp.690-699, 2003.
DOI : 10.1038/nrm1200

S. D. Shapira, I. Gat-viks, B. O. Shum, A. Dricot, M. M. De-grace et al., A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection, Cell, vol.139, issue.7, pp.1255-1267, 2009.
DOI : 10.1016/j.cell.2009.12.018

J. Stech, H. Garn, M. Wegmann, R. Wagner, and H. D. Klenk, A new approach to an influenza live vaccine: modification of the cleavage site of hemagglutinin, Nature Medicine, vol.17, issue.6, pp.683-689, 2005.
DOI : 10.1007/BF01309867

K. Subbarao, Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness, Science, vol.279, issue.5349, pp.393-396, 1998.
DOI : 10.1126/science.279.5349.393

Y. Tang, G. Zhong, L. Zhu, X. Liu, Y. Shan et al., Herc5 Attenuates Influenza A Virus by Catalyzing ISGylation of Viral NS1 Protein, The Journal of Immunology, vol.184, issue.10, pp.5777-5790, 2010.
DOI : 10.4049/jimmunol.0903588

C. H. Tseng, T. S. Cheng, C. Y. Shu, K. S. Jeng, and M. M. Lai, Modification of Small Hepatitis Delta Virus Antigen by SUMO Protein, Journal of Virology, vol.84, issue.2, pp.918-927, 2010.
DOI : 10.1128/JVI.01034-09

A. Verger, J. Perdomo, and M. Crossley, Modification with SUMO, EMBO reports, vol.22, issue.2, pp.137-142, 2003.
DOI : 10.1038/sj.embor.embor738

R. G. Webster, W. J. Bean, O. T. Gorman, T. M. Chambers, and Y. Kawaoka, Evolution and ecology of influenza A viruses, Microbiol. Rev, vol.56, pp.152-179, 1992.

V. G. Wilson and D. Rangasamy, Viral interaction with the host cell sumoylation system, Virus Research, vol.81, issue.1-2, pp.17-27, 2001.
DOI : 10.1016/S0168-1702(01)00365-3

C. Zhao, T. Y. Hsiang, R. L. Kuo, and R. M. Krug, ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells, Proceedings of the National Academy of Sciences, vol.107, issue.5, pp.2253-2258, 2010.
DOI : 10.1073/pnas.0909144107