J. Cohen, The Scientific Challenge of Hepatitis C, Science, vol.285, issue.5424, pp.26-30, 1999.
DOI : 10.1126/science.285.5424.26

G. Lauer and B. Walker, Hepatitis C Virus Infection, New England Journal of Medicine, vol.345, issue.1, pp.41-52, 2001.
DOI : 10.1056/NEJM200107053450107

J. Berzofsky, J. Ahlers, J. Janik, J. Morris, and S. Oh, Progress on new vaccine strategies against chronic viral infections, Journal of Clinical Investigation, vol.114, issue.4, pp.450-462, 2004.
DOI : 10.1172/JCI22674DS1

T. Liang, B. Rehermann, L. Seeff, and J. Hoofnagle, Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C, Annals of Internal Medicine, vol.132, issue.4, pp.296-305, 2000.
DOI : 10.7326/0003-4819-132-4-200002150-00008

C. Gremion and A. Cerny, Hepatitis C virus and the immune system: a concise review, Reviews in Medical Virology, vol.38, issue.4, pp.235-268, 2005.
DOI : 10.1002/rmv.466

C. Day and B. Walker, Progress in Defining CD4 Helper Cell Responses in Chronic Viral Infections: Figure 1., The Journal of Experimental Medicine, vol.72, issue.12, pp.1773-1777, 2003.
DOI : 10.1038/ni832

G. Missale, R. Bertoni, V. Lamonaca, A. Valli, and M. Massari, Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response., Journal of Clinical Investigation, vol.98, issue.3, pp.706-714, 1996.
DOI : 10.1172/JCI118842

H. Diepolder, R. Zachoval, R. Hoffmann, E. Wierenga, and T. Santantonio, Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection, The Lancet, vol.346, issue.8981, pp.1006-1007, 1995.
DOI : 10.1016/S0140-6736(95)91691-1

D. Eckels, H. Wang, T. Bian, N. Tabatabai, and J. Gill, Immunobiology of hepatitis C virus (HCV) infection: the role of CD4 T??cells in HCV infection, Immunological Reviews, vol.174, issue.1, pp.90-97, 2000.
DOI : 10.1034/j.1600-0528.2002.017403.x

N. Shoukry, A. Cawthon, and C. Walker, Cell-Mediated Immunity and the Outcome of Hepatitis C Virus Infection, Annual Review of Microbiology, vol.58, issue.1, pp.391-424, 2004.
DOI : 10.1146/annurev.micro.58.030603.123836

R. Cardin, J. Brooks, S. Sarawar, and P. Doherty, Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells, Journal of Experimental Medicine, vol.184, issue.3, pp.863-871, 1996.
DOI : 10.1084/jem.184.3.863

O. Planz, S. Ehl, E. Furrer, E. Horvath, and M. Brundler, A critical role for neutralizing-antibody-producing B cells, CD4+ T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: Implications for adoptive immunotherapy of virus carriers, Proceedings of the National Academy of Sciences, vol.94, issue.13, pp.6874-6879, 1997.
DOI : 10.1073/pnas.94.13.6874

S. Boulant, M. Becchi, F. Penin, and J. Lavergne, Unusual Multiple Recoding Events Leading to Alternative Forms of Hepatitis C Virus Core Protein from Genotype 1b, Journal of Biological Chemistry, vol.278, issue.46, pp.45785-45792, 2003.
DOI : 10.1074/jbc.M307174200

URL : https://hal.archives-ouvertes.fr/hal-00313696

A. Branch, D. Stump, J. Gutierrez, F. Eng, and J. Walewski, The Hepatitis C Virus Alternate Reading Frame (ARF) and Its Family of Novel Products: The Alternate Reading Frame Protein/F-Protein, the Double-Frameshift Protein, and Others, Seminars in Liver Disease, vol.25, issue.01, pp.105-117, 2005.
DOI : 10.1055/s-2005-864786

N. Vassilaki and P. Mavromara, The HCV ARFP/F/core+1 protein: Production and functional analysis of an unconventional viral product, IUBMB Life, vol.76, issue.Part 11, pp.739-752, 2009.
DOI : 10.1002/iub.201

F. Komurian-pradel, A. Rajoharison, J. Berland, V. Khouri, and M. Perret, Antigenic relevance of F protein in chronic hepatitis C virus infection, Hepatology, vol.84, issue.4, pp.900-909, 2004.
DOI : 10.1002/hep.20406

D. Gao, X. Zhang, G. Hou, G. Jin, and Q. Deng, Assessment of Specific Antibodies to F Protein in Serum Samples from Chinese Hepatitis C Patients Treated with Interferon plus Ribavarin, Journal of Clinical Microbiology, vol.46, issue.11, pp.3746-3751, 2008.
DOI : 10.1128/JCM.00612-08

M. Mancini-bourgine, F. Bayard, P. Soussan, Q. Deng, and Y. Lone, Hepatitis B Virus Splice-Generated Protein Induces T-Cell Responses in HLA-Transgenic Mice and Hepatitis B Virus-Infected Patients, Journal of Virology, vol.81, issue.10, pp.4963-4972, 2007.
DOI : 10.1128/JVI.02619-06

C. Bain, P. Parroche, J. Lavergne, B. Duverger, and C. Vieux, Memory T-Cell-Mediated Immune Responses Specific to an Alternative Core Protein in Hepatitis C Virus Infection, Journal of Virology, vol.78, issue.19, pp.10460-10469, 2004.
DOI : 10.1128/JVI.78.19.10460-10469.2004

URL : https://hal.archives-ouvertes.fr/hal-00313685

C. Drouin, S. Lamarche, J. Bruneau, H. Soudeyns, and N. Shoukry, Cell-mediated immune responses directed against hepatitis C virus (HCV) alternate reading frame protein (ARFP) are undetectable during acute infection, Journal of Clinical Virology, vol.47, issue.1, pp.102-103, 2010.
DOI : 10.1016/j.jcv.2009.10.016

S. Pascolo, HLA class I transgenic mice: development, utilisation and improvement, Expert Opinion on Biological Therapy, vol.34, issue.7, pp.919-938, 2005.
DOI : 10.1016/1074-7613(95)90159-0

R. Singh, R. Kaul, A. Kaul, and K. Khan, A comparative review of HLA associations with hepatitis B and C viral infections across global populations, World Journal of Gastroenterology, vol.13, issue.12, pp.1770-1787, 2007.
DOI : 10.3748/wjg.v13.i12.1770

S. Barrett, E. Ryan, and J. Crowe, Association of the HLA-DRB1*01 allele with spontaneous viral clearance in an Irish cohort infected with hepatitis C virus via contaminated anti-D immunoglobulin, Journal of Hepatology, vol.30, issue.6, pp.979-983, 1999.
DOI : 10.1016/S0168-8278(99)80249-9

S. Tsai, Y. Liaw, M. Chen, C. Huang, and G. Kuo, Detection of type 2-like T-helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity, Hepatology, vol.25, issue.2, pp.449-458, 1997.
DOI : 10.1002/hep.510250233

R. Woitas, M. Lechmann, G. Jung, R. Kaiser, and T. Sauerbruch, CD30 induction and cytokine profiles in hepatitis C virus core-specific peripheral blood T lymphocytes, J Immunol, vol.159, pp.1012-1018, 1997.

A. Ulsenheimer, J. Gerlach, N. Gruener, M. Jung, and C. Schirren, Detection of functionally altered hepatitis C virus-specific CD4+ T cells in acute and chronic hepatitis C, Hepatology, vol.181, issue.5, pp.1189-1198, 2003.
DOI : 10.1053/jhep.2003.50194

H. Rosen, C. Miner, A. Sasaki, D. Lewinsohn, and A. Conrad, Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: Correlation with clinical disease stages, Hepatology, vol.15, issue.1, pp.190-198, 2002.
DOI : 10.1053/jhep.2002.30293

A. Wertheimer, C. Miner, D. Lewinsohn, A. Sasaki, and E. Kaufman, Novel CD4+ and CD8+ T-cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection, Hepatology, vol.359, issue.3, pp.577-589, 2003.
DOI : 10.1053/jhep.2003.50115

N. Semmo, G. Krashias, C. Willberg, and P. Klenerman, Analysis of the relationship between cytokine secretion and proliferative capacity in hepatitis C virus infection, Journal of Viral Hepatitis, vol.365, issue.9456, pp.492-502, 2007.
DOI : 10.1128/JVI.76.6.2817-2826.2002

M. Mancini, H. Davis, P. Tiollais, and M. Michel, DNA-based immunization against the envelope proteins of the hepatitis B virus, Journal of Biotechnology, vol.44, issue.1-3, pp.47-57, 1996.
DOI : 10.1016/0168-1656(95)00098-4

H. Nakabayashi, K. Taketa, T. Yamane, M. Miyazaki, and K. Miyano, Phenotypical stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium, Gann, vol.75, pp.151-158, 1984.

P. Bedossa and T. Poynard, An algorithm for the grading of activity in chronic hepatitis C, Hepatology, vol.24, issue.2, pp.289-293, 1996.
DOI : 10.1002/hep.510240201

C. Day, G. Lauer, G. Robbins, B. Mcgovern, and A. Wurcel, Broad Specificity of Virus-Specific CD4+ T-Helper-Cell Responses in Resolved Hepatitis C Virus Infection, Journal of Virology, vol.76, issue.24, pp.12584-12595, 2002.
DOI : 10.1128/JVI.76.24.12584-12595.2002