G. Henle, W. Henle, and V. Diehl, Relation of Burkitt's tumor-associated herpes-ytpe virus to infectious mononucleosis., Proceedings of the National Academy of Sciences, vol.59, issue.1, pp.94-101, 1968.
DOI : 10.1073/pnas.59.1.94

H. Knecht, C. Berger, A. Homsi, C. Mcquain, and P. Brousset, Epstein-Barr virus oncogenesis, Critical Reviews in Oncology/Hematology, vol.26, issue.2, pp.117-152, 1997.
DOI : 10.1016/S1040-8428(97)00016-4

A. Benider, S. Sahraoui, A. Acharki, R. Samlali, and A. Kahlain, Carcinomas of the nasopharynx in children. Analysis of 50 cases, Bull Cancer, vol.82, issue.2, pp.155-61, 1995.

N. Chaouki and B. Gueddari, Epidemiological descriptive approach of cancer in Morocco through the activity of the National Institute of Oncology, Bull Cancer, vol.78, pp.603-612, 1986.

F. Chen, L. Hu, I. Ernberg, G. Klein, and G. Winberg, Coupled transcription of Epstein--Barr virus latent membrane protein (LMP)-1 and LMP-2B genes in nasopharyngeal carcinomas, Journal of General Virology, vol.76, issue.1, pp.131-139, 1995.
DOI : 10.1099/0022-1317-76-1-131

D. Wang, D. Liebowitz, and E. Kieff, An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells, Cell, vol.43, issue.3, pp.831-871, 1985.
DOI : 10.1016/0092-8674(85)90256-9

C. Dawson, A. Rickinson, and L. Young, Epstein???Barr virus latent membrane protein inhibits human epithelial cell differentiation, Nature, vol.344, issue.6268, pp.777-80, 1990.
DOI : 10.1038/344777a0

T. Yoshizaki, H. Sato, M. Furukawa, and J. Pagano, The expression of matrix metalloproteinase 9 is enhanced by Epstein-Barr virus latent membrane protein 1, Proceedings of the National Academy of Sciences, vol.95, issue.7, pp.3621-3627, 1998.
DOI : 10.1073/pnas.95.7.3621

J. Lu, H. Chua, S. Chen, J. Chen, and C. Tsai, Regulation of matrix metalloproteinase-1 by Epstein-Barr virus proteins, Cancer Res, vol.63, pp.256-62, 2003.

W. Miller, H. Earp, and N. Raab-traub, The Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor, J Virol, vol.69, pp.4390-4398, 1995.

S. Murono, H. Inoue, T. Tanabe, J. I. Yoshizaki, T. Furukawa et al., Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells, Proceedings of the National Academy of Sciences, vol.98, issue.12, pp.6905-6915, 2001.
DOI : 10.1073/pnas.121016998

S. Henderson, M. Rowe, C. Gregory, D. Croom-carter, F. Wang et al., Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death, Cell, vol.65, issue.7, pp.1107-1122, 1991.
DOI : 10.1016/0092-8674(91)90007-L

S. Wang, M. Rowe, and E. Lundgren, Expression of the Epstein-Barr virus transforming protein LMP1 causes a rapid and transient stimulation of the Bcl-2 homologue Mcl-1 levels in B-cell lines, Cancer Res, vol.56, pp.4610-4613, 1996.

C. Gregory, R. Murray, C. Edwards, and A. Rickinson, Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein- Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance, Journal of Experimental Medicine, vol.167, issue.6, pp.1811-1835, 1988.
DOI : 10.1084/jem.167.6.1811

M. Rowe, M. Peng-pilon, D. Huen, R. Hardy, D. Croom-carter et al., Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-j B activation and to induction of cell surface markers, J Virol, vol.68, pp.5602-5614, 1994.

E. Paine, R. Scheinman, A. Baldwin, . Jr, and N. Raab-traub, Expression of LMP1 in epithelial cells leads to the activation of a select subset of NF-j B/Rel family proteins, J Virol, vol.69, pp.4572-4578, 1995.

O. Devergne, C. Mcfarland, E. Mosialos, G. Izumi, K. Ware et al., Role of the TRAF binding site and NF-jB activation in Epstein-Barr virus latent membrane protein 1-induced cell gene expression, J Virol, vol.72, pp.7900-7908, 1998.

W. Miller, G. Mosialos, E. Kieff, and N. Raab-traub, Epstein-Barr virus LMP1 induction of the epidermal growth factor receptor is mediated through a TRAF signaling pathway distinct from NF-jB activation, J Virol, vol.71, pp.586-94, 1997.

K. Izumi, K. Kaye, and E. Kieff, The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation, Proceedings of the National Academy of Sciences, vol.94, issue.4, pp.1447-52, 1997.
DOI : 10.1073/pnas.94.4.1447

A. Eliopoulos, N. Gallagher, S. Blake, C. Dawson, and L. Young, Activation of the p38 Mitogen-activated Protein Kinase Pathway by Epstein-Barr Virus-encoded Latent Membrane Protein 1 Coregulates Interleukin-6 and Interleukin-8 Production, Journal of Biological Chemistry, vol.274, issue.23, pp.16085-96, 1999.
DOI : 10.1074/jbc.274.23.16085

A. Kieser, E. Kilger, O. Gires, M. Ueffing, W. Kolch et al., Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade, The EMBO Journal, vol.16, issue.21, pp.6478-85, 1997.
DOI : 10.1093/emboj/16.21.6478

C. Laherty, H. Hu, A. Opipari, F. Wang, and V. Dixit, The Epstein- Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor j B, J Biol Chem, vol.267, pp.24157-60, 1992.

O. Gires, F. Kohlhuber, E. Kilger, M. Baumann, A. Kieser et al., Latent membrane protein 1of Epstein-Barr virus interacts with JAK3 and activates STAT proteins, The EMBO Journal, vol.18, issue.11, pp.3064-73, 1999.
DOI : 10.1093/emboj/18.11.3064

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171388

S. Blake, A. Eliopoulos, C. Dawson, and L. Young, The Transmembrane Domains of the EBV-Encoded Latent Membrane Protein 1 (LMP1) Variant CAO Regulate Enhanced Signalling Activity, Virology, vol.282, issue.2, pp.278-87, 2001.
DOI : 10.1006/viro.2001.0828

M. Chen, C. Tsai, C. Liang, C. Shu, C. Huang et al., Cloning and characterization of the latent membrane protein (LMP) of a specific Epstein-Barr virus variant derived from the nasopharyngeal carcinoma in the Taiwanese population, Oncogene, vol.7, pp.2131-2171, 1992.

S. Li, Y. Chang, and S. Liu, Effect of a 10-amino acid deletion on the oncogenic activity of latent membrane protein 1 of Epstein-Barr virus, Oncogene, vol.12, pp.2129-2164, 1996.

R. Edwards, F. Seillier-moiseiwitsch, and N. Raab-traub, Signature Amino Acid Changes in Latent Membrane Protein 1 Distinguish Epstein???Barr Virus Strains, Virology, vol.261, issue.1, pp.79-95, 1999.
DOI : 10.1006/viro.1999.9855

L. Hu, E. Zabarovsky, F. Chen, S. Cao, I. Ernberg et al., Isolation and sequencing of the Epstein-Barr virus BNLF-1 gene (LMP1) from a Chinese nasopharyngeal carcinoma, Journal of General Virology, vol.72, issue.10, pp.2399-409, 1991.
DOI : 10.1099/0022-1317-72-10-2399

M. Bouzid, D. Djennaoui, J. Dubreuil, A. Bouguermouh, D. Ellouz et al., Epstein-barr virus genotypes in NPC biopsies from North Africa, International Journal of Cancer, vol.228, issue.4, pp.468-73, 1994.
DOI : 10.1002/ijc.2910560403

V. Grunewald, M. Bonnet, S. Boutin, T. Yip, H. Louzir et al., Amino-acid change in the Epstein-Barr-virus zebra protein in undifferentiated nasopharyngeal carcinomas from Europe and North Africa, International Journal of Cancer, vol.14, issue.4, pp.497-503, 1998.
DOI : 10.1002/(SICI)1097-0215(19980209)75:4<497::AID-IJC2>3.0.CO;2-O

R. Edwards, D. Sitki-green, D. Moore, and N. Raab-traub, Potential Selection of LMP1 Variants in Nasopharyngeal Carcinoma, Journal of Virology, vol.78, issue.2, pp.868-81, 2004.
DOI : 10.1128/JVI.78.2.868-881.2004

A. Bertoletti, A. Sette, F. Chisari, A. Penna, M. Levrero et al., Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells, Nature, vol.369, issue.6479, pp.407-417, 1994.
DOI : 10.1038/369407a0

J. Burrows, S. Burrows, L. Poulsen, T. Sculley, D. Moss et al., Unusually high frequency of Epstein-Barr virus genetic variants in Papua New Guinea that can escape cytotoxic T-cell recognition: implications for virus evolution, J Virol, vol.70, pp.2490-2496, 1996.

R. Dardari, M. Khyatti, H. Jouhadi, A. Benider, H. Ettayebi et al., Study of human leukocyte antigen class I phenotypes in Moroccan patients with nasopharyngeal carcinoma, International Journal of Cancer, vol.5, issue.2, pp.294-301, 2001.
DOI : 10.1002/1097-0215(200102)9999:9999<::AID-IJC1177>3.0.CO;2-9

URL : https://hal.archives-ouvertes.fr/pasteur-00647025

Y. Liu, X. Wang, A. Lo, Y. Wong, A. Cheung et al., Latent membrane protein-1 of Epstein-Barr virus inhibits cell growth and induces sensitivity to cisplatin in nasopharyngeal carcinoma cells, Journal of Medical Virology, vol.31, issue.1, pp.63-72, 2002.
DOI : 10.1002/jmv.2112

S. Tsao, X. Wang, Y. Liu, Y. Cheung, H. Feng et al., Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1590, issue.1-3, pp.1-3150, 2002.
DOI : 10.1016/S0167-4889(02)00208-2

P. Brennan, J. Floettmann, A. Mehl, M. Jones, and M. Rowe, Mechanism of Action of a Novel Latent Membrane Protein-1 Dominant Negative, Journal of Biological Chemistry, vol.276, issue.2, pp.1195-203, 2001.
DOI : 10.1074/jbc.M005461200

H. Chen, J. Lee, Y. Zong, M. Borowitz, M. Ng et al., Linkage between STAT Regulation and Epstein-Barr Virus Gene Expression in Tumors, Journal of Virology, vol.75, issue.6, pp.2929-2966, 2001.
DOI : 10.1128/JVI.75.6.2929-2937.2001

R. Moorthy and D. Thorley-lawson, All three domains of the Epstein- Barr virus-encoded latent membrane protein LMP-1 are required for transformation of rat-1 fibroblasts, J Virol, vol.67, pp.1638-1684, 1993.