Abstract : Previous reports demonstrated an association between the human leukocyte antigen (HLA) and risk for nasopharyngeal carcinoma (NPC) among the Chinese in Singapore, a population with a high incidence of this malignancy. In our study, we assess the association between HLA and NPC in Morocco, a median-prevalence area for this cancer, where NPC presents the particularity of also affecting young individuals. Using the standard microlympho-cytotoxicity test, we typed a total of 154 Moroccan NPC patients and 257 unrelated healthy controls for their HLA-A and B antigens. The results of these analyses show that the frequencies of HLA-A10, HLA-B13 and HLA-B18 were found to be higher in the NPC group than in the control group, whereas HLA-A9 was associated with a decreased risk. After correction for the number of specificities tested, these differences were statistically significant only for HLA-B18 (corrected p value [pc] < 0.023, relative risk [RR] = 4.14) and HLA-A9 (pc < 0.023, RR = 0.45). The comparison of the distribution of the HLA antigens in younger and older cohorts of patients shows that the incidence of HLA-A10 and HLA- B18 was higher in the older group, whereas the frequencies of HLA-A19 and HLA-B13 were significantly higher in younger patients compared with controls. The presence of both HLA-A19 and HLA-B13 phenotypes correlated with an increased risk of developing NPC among overall patients compared with controls. According to the sex distribution, increased frequency of HLA-B18 was found in male and female NPC patients compared with controls, whereas the frequency of HLA-A10 was higher only in male NPC patients compared with controls.
https://hal-riip.archives-ouvertes.fr/pasteur-00647025
Contributor : Meriem Khyatti
<>
Submitted on : Thursday, December 1, 2011 - 11:51:30 AM
Last modification on : Monday, October 8, 2018 - 5:44:08 PM
Long-term archiving on : Sunday, December 4, 2016 - 8:42:41 PM
File
Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed
until : jamais
R. Dardari, M. Khyatti, H. Jouhadi, A. Benider, H. Ettayebi, et al.. Study of human leukocyte antigen class I phenotypes in Moroccan patients with nasopharyngeal carcinoma.. International Journal of Cancer, Wiley, 2001, 92 (2), pp.294-7. ⟨pasteur-00647025⟩
