D. Porro, B. Gasser, T. Fossati, M. Maurer, P. Branduardi et al., Production of recombinant proteins and metabolites in yeasts, Applied Microbiology and Biotechnology, vol.40, issue.4, pp.939-987, 2011.
DOI : 10.1007/s00253-010-3019-z

A. Demain and P. Vaishnav, Production of recombinant proteins by microbes and higher organisms, Biotechnology Advances, vol.27, issue.3, pp.297-306, 2009.
DOI : 10.1016/j.biotechadv.2009.01.008

S. Müller, T. Sandal, P. Kamp-hansen, and H. Dalbøge, Comparison of expression systems in the yeasts Saccharomyces cerevisiae, Hansenula polymorpha, Klyveromyces lactis, Schizosaccharomyces pombe and Yarrowia lipolytica. cloning of two novel promoters from Yarrowia lipolytica, Yeast, vol.14, issue.14, pp.1267-83, 1998.
DOI : 10.1002/(SICI)1097-0061(1998100)14:14<1267::AID-YEA327>3.3.CO;2-U

G. Barth and C. Gaillardin, Yarrowia lipolytica In Non conventional yeasts in biotechnology, pp.313-388, 1996.

P. Fickers, P. Benetti, Y. Waché, A. Marty, S. Mauersberger et al., Hydrophobic substrate utilisation by the yeast , and its potential applications, FEMS Yeast Research, vol.5, issue.6-7, pp.527-570, 2005.
DOI : 10.1016/j.femsyr.2004.09.004
URL : https://hal.archives-ouvertes.fr/hal-00368201

C. Madzak, C. Gaillardin, and J. Beckerich, Heterologous protein expression and secretion in the non-conventional yeast Yarrowia lipolytica: a review, Journal of Biotechnology, vol.109, issue.1-2, pp.63-81, 2004.
DOI : 10.1016/j.jbiotec.2003.10.027

T. Arzumanov, N. Shishkanova, and T. Finogenova, Biosynthesis of citric acid by Yarrowia lipolytica repeat-batch culture on ethanol, Applied Microbiology and Biotechnology, vol.53, issue.5, pp.525-534, 2000.
DOI : 10.1007/s002530051651

J. Nicaud, C. Madzak, P. Van-den-broek, C. Gysler, P. Duboc et al., Protein expression and secretion in the yeast Yarrowia lipolytica, FEMS Yeast Res, vol.2, pp.371-379, 2002.

T. Juretzek, H. Wang, J. Nicaud, S. Mauersberger, and G. Barth, Comparison of promoters suitable for regulated overexpression of ??-galactosidase in the alkane-utilizing yeastYarrowia lipolytica, Biotechnology and Bioprocess Engineering, vol.25, issue.5, pp.320-326, 2000.
DOI : 10.1007/BF02942206

M. Nthangeni, P. Urban, D. Pompon, M. Smit, and J. Nicaud, The use ofYarrowia lipolytica for the expression of human cytochrome P450 CYP1A1, Yeast, vol.21, issue.7, pp.583-92, 2004.
DOI : 10.1002/yea.1127

A. Shiningavamwe, G. Obiero, J. Albertyn, J. Nicaud, and M. Smit, Heterologous expression of the benzoate para-hydroxylase encoding gene (CYP53B1) from Rhodotorula minuta by Yarrowia lipolytica, Applied Microbiology and Biotechnology, vol.1, issue.2, pp.323-332, 2006.
DOI : 10.1007/s00253-005-0264-7
URL : https://hal.archives-ouvertes.fr/hal-00164145

S. Kohlwein and F. Paltauf, Uptake of fatty acids by the yeasts, Saccharomyces uvarum and Saccharomycopsis lipolytica, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol.792, issue.3, pp.310-317, 1984.
DOI : 10.1016/0005-2760(84)90198-X

M. Gordillo, A. Sanz, A. Sànchez, F. Valero, J. Montesinos et al., Enhancement of Candida rugosa lipase production by using different control fed???batch operational strategies, Biotechnology and Bioengineering, vol.60, issue.2, pp.156-168, 1998.
DOI : 10.1002/(SICI)1097-0290(19981020)60:2<156::AID-BIT3>3.3.CO;2-Q

O. Cos, R. Ramón, J. Montesinos, and F. Valero, Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters, Microbial Cell Factories, pp.5-17, 2006.

M. Krause, K. Haataja, M. Ruottinen, T. Glumoff, A. Neubauer et al., A novel fed-batch based cultivation method provides high celldensity and improves yield of soluble recombinant proteins in shaken cultures, Microbial Cell Factories, vol.2010, pp.9-11

M. Chelbi-alix and J. Wietzerbin, Interferon, a growing cytokine family: 50 years of interferon research, Biochimie, vol.89, issue.6-7, pp.713-718, 2007.
DOI : 10.1016/j.biochi.2007.05.001
URL : https://hal.archives-ouvertes.fr/inserm-00170725

G. Sen and P. Lengyel, The interferon system, J Biol Chem, vol.267, pp.5017-5020, 1992.

S. Parmar and L. Platanias, Interferons: mechanisms of action and clinical applications, Current Opinion in Oncology, vol.15, issue.6, pp.431-440, 2003.
DOI : 10.1097/00001622-200311000-00005

J. Mcgrew, D. Leiske, B. Dell, R. Klinke, D. Krasts et al., Expression of trimeric CD40 ligand in Pichia pastoris: use of a rapid method to detect high-level expressing transformants, Gene, vol.187, issue.2, pp.193-200, 1997.
DOI : 10.1016/S0378-1119(96)00747-0

J. Pinsach, D. Mas, C. López-santín, and J. , Induction strategies in fed-batch cultures for recombinant protein production in Escherichia coli: Application to rhamnulose 1-phosphate aldolase, Biochemical Engineering Journal, vol.41, issue.2, pp.181-187, 2008.
DOI : 10.1016/j.bej.2008.04.013

Y. Wang, Z. Wang, G. Du, Z. Hua, L. Liu et al., Enhancement of alkaline polygalacturonate lyase production in recombinant Pichia pastoris according to the ratio of methanol to cell concentration, Bioresource Technology, vol.100, issue.3, pp.1343-1352, 2009.
DOI : 10.1016/j.biortech.2008.07.049

V. Titorenko, J. Nicaud, H. Wang, H. Chan, and R. Rachubinski, Acyl-CoA oxidase is imported as a heteropentameric, cofactor-containing complex into peroxisomes of Yarrowia lipolytica, J Cell Biol, vol.4, pp.481-94, 2002.

D. Glover, R. Mcewen, C. Thomas, and T. Young, pH-regulated expression of the acid and alkaline extracellular proteases of Yarrowia lipolytica, Microbiology, vol.143, issue.9, pp.3045-54, 1997.
DOI : 10.1099/00221287-143-9-3045

R. Radhakrishnan, L. Walter, A. Hruza, P. Reichert, P. Trotta et al., Zinc mediated dimer of human interferon-??2b revealed by X-ray crystallography, Structure, vol.4, issue.12, pp.1453-63, 1996.
DOI : 10.1016/S0969-2126(96)00152-9
URL : http://doi.org/10.1016/s0969-2126(96)00152-9

N. Gasmi, F. Fudalej, H. Kallel, and J. Nicaud, A molecular approach to optimize hIFN ??2b expression and secretion in Yarrowia lipolytica, Applied Microbiology and Biotechnology, vol.16, issue.5, pp.109-119, 2011.
DOI : 10.1007/s00253-010-2803-0
URL : https://hal.archives-ouvertes.fr/pasteur-00606851

N. Gasmi, A. Ayed, J. Nicaud, and H. Kallel, Design of an efficient medium for heterologous protein production in Yarrowia lipolytica: case of human interferon alpha 2b. Microbial Cell Factories, pp.10-38, 2011.
URL : https://hal.archives-ouvertes.fr/pasteur-00606850

S. Turki, A. Ayed, N. Chalghoumi, F. Weekers, P. Thonart et al., An Enhanced Process for the Production of a Highly Purified Extracellular Lipase in the Non-conventional Yeast Yarrowia lipolytica, Applied Biochemistry and Biotechnology, vol.22, issue.11, pp.1371-85, 2010.
DOI : 10.1007/s12010-009-8599-7
URL : https://hal.archives-ouvertes.fr/pasteur-00621002

U. Laemmli, Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4, Nature, vol.244, issue.5259, pp.680-685, 1970.
DOI : 10.1038/227680a0

C. Frings and R. Dunn, A Colorimetric Method for Determination of Total Serum Lipids Based on the Sulfo-phospho-vanillin Reaction, American Journal of Clinical Pathology, vol.53, issue.1, pp.89-91, 1970.
DOI : 10.1093/ajcp/53.1.89

A. Ayed, I. Rabhi, K. Dellagi, and H. Kallel, High level production and purification of human interferon ??2b in high cell density culture of Pichia pastoris, Enzyme and Microbial Technology, vol.42, issue.2, pp.173-180, 2008.
DOI : 10.1016/j.enzmictec.2007.09.006
URL : https://hal.archives-ouvertes.fr/pasteur-00870936

. Gasmi, Development of a cultivation process for the enhancement of human interferon alpha 2b production in the oleaginous yeast, Yarrowia lipolytica. Microbial Cell Factories 2011 10:90. Submit your next manuscript to BioMed Central and take full advantage of
URL : https://hal.archives-ouvertes.fr/pasteur-00657955

. Gasmi, Microbial Cell Factories, p.9090, 2011.