A Secondary Sialic Acid Binding Site on Influenza Virus Neuraminidase: Fact or Fiction?

Abstract : One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is still detected. Thus the sialyllactose must bind at a secondary sialic acid binding site (see structures: docking study of α(2,3)-sialyllactose in the secondary binding site of avian flu neuraminidase).
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Submitted on : Sunday, January 29, 2012 - 5:19:50 PM
Last modification on : Monday, August 12, 2019 - 2:20:30 PM

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Jimmy C. C. Lai, Jean-Michel Garcia, Jeffrey C. Dyason, Raphael Böhm, Paul D. Madge, et al.. A Secondary Sialic Acid Binding Site on Influenza Virus Neuraminidase: Fact or Fiction?. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2012, epub ahead of print. ⟨10.1002/anie.201108245⟩. ⟨pasteur-00664159⟩

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