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Journal articles
A Secondary Sialic Acid Binding Site on Influenza Virus Neuraminidase: Fact or Fiction?
Jimmy C. C. Lai
1
Jean-Michel Garcia
1
Jeffrey C. Dyason
2
Raphael Böhm
2
Paul D. Madge
2
Faith J. Rose
2
John M. Nicholls
3
J. S. Malik Peiris
1
Thomas Haselhorst
2, *
Mark von Itzstein
2, *
*
Corresponding author
Jimmy C. C. Lai 1
Author
Jean-Michel Garcia 1
Author
Jeffrey C. Dyason 2
Author
Raphael Böhm 2
Author
Thomas Haselhorst 2
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Correspondent author
Mark von Itzstein 2
Mail :
Correspondent author
1
Centre de recherche Université de Hong-Kong-Pasteur (Hong Kong University Pasteur Research Centre - 1/F Dexter HC Man Building 8, Sassoon Road Pokfulam - Hong Kong SAR China)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
2
Institute for Glycomics (Gold Coast Campus, Queensland 4222
- Australia)
- Griffith University [Brisbane] (PO Box 3370 South Brisbane QLD 4101 - Australia)
3
Department of pathology [HKU] (21 Sassoon Road, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region - China)
- HKU - The University of Hong Kong (Pokfulam, Hong Kong - Hong Kong SAR China)
Abstract : One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is still detected. Thus the sialyllactose must bind at a secondary sialic acid binding site (see structures: docking study of α(2,3)-sialyllactose in the secondary binding site of avian flu neuraminidase).
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https://hal-riip.archives-ouvertes.fr/pasteur-00664159
Contributor : Francois Kien <>
Submitted on : Sunday, January 29, 2012 - 5:19:50 PM
Last modification on : Monday, August 12, 2019 - 2:20:30 PM
Contributor : Francois Kien <>
Submitted on : Sunday, January 29, 2012 - 5:19:50 PM
Last modification on : Monday, August 12, 2019 - 2:20:30 PM
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- HAL Id : pasteur-00664159, version 1
- DOI : 10.1002/anie.201108245
- PUBMED : 22281708
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Jimmy C. C. Lai, Jean-Michel Garcia, Jeffrey C. Dyason, Raphael Böhm, Paul D. Madge, et al.. A Secondary Sialic Acid Binding Site on Influenza Virus Neuraminidase: Fact or Fiction?. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2012, epub ahead of print. ⟨10.1002/anie.201108245⟩. ⟨pasteur-00664159⟩
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