P. Meikle, J. Hopwood, A. Clague, and W. Carey, Prevalence of Lysosomal Storage Disorders, JAMA, vol.281, issue.3, pp.249-254, 1999.
DOI : 10.1001/jama.281.3.249

E. Sidransky, Gaucher disease: complexity in a ???simple??? disorder, Molecular Genetics and Metabolism, vol.83, issue.1-2, pp.6-15, 2004.
DOI : 10.1016/j.ymgme.2004.08.015

O. Neudorfer, N. Giladi, D. Elstein, A. Abrahamov, T. Turezkite et al., Occurrence of Parkinson's syndrome in type 1 Gaucher disease, QJM, vol.89, issue.9, pp.691-694, 1996.
DOI : 10.1093/qjmed/89.9.691

W. Cherif, B. Turkia, H. Tebib, N. Amaral, O. et al., Mutation spectrum of Gaucher disease in Tunisia: high frequency of N370S/ RecNciI compound heterozygous, Arch Inst Pasteur Tunis, vol.84, pp.65-70, 2007.

W. Cherif, B. Turkia, H. , B. Rhouma, F. Riahi et al., Gaucher disease in Tunisia: High frequency of the most common mutations, Blood Cells, Molecules, and Diseases, vol.43, issue.2, pp.161-162, 2009.
DOI : 10.1016/j.bcmd.2009.05.004

A. Dandana, S. Ferchichi, S. Khedhiri, L. Chkioua, Z. Jaidane et al., Biochemical and molecular diagnosis of Gaucher disease in Tunisia, Ann Biol Clin, vol.65, pp.647-652, 2007.

C. Fairley, A. Zimran, M. Phillips, M. Cizmarik, Y. J. Weinreb et al., Phenotypic heterogeneity of N370S homozygotes with type I Gaucher disease: An analysis of 798 patients from the ICGG Gaucher Registry, Journal of Inherited Metabolic Disease, vol.66, issue.6, pp.738-744, 2008.
DOI : 10.1007/s10545-008-0868-z

A. Zimran, T. Gelbart, B. Westwood, G. Grabowski, and E. Beutler, High frequency of the Gaucher disease mutation at nucleotide 1226 among Ashkenazi Jews, Am J Hum Genet, vol.49, pp.855-859, 1991.

J. Capablo, A. Saenz-de-cabezón, J. Fraile, P. Alfonso, M. Pocovi et al., Neurological evaluation of patients with Gaucher disease diagnosed as type 1, Journal of Neurology, Neurosurgery & Psychiatry, vol.79, issue.2, pp.219-222, 2008.
DOI : 10.1136/jnnp.2006.111518

O. Goker-alpan, G. Lopez, J. Vithayathil, J. Davis, M. Hallett et al., The Spectrum of Parkinsonian Manifestations Associated With Glucocerebrosidase Mutations, Archives of Neurology, vol.65, issue.10, pp.1353-1357, 2008.
DOI : 10.1001/archneur.65.10.1353

K. Nishioka, C. Vilariño-güell, S. Cobb, J. Kachergus, O. Ross et al., Glucocerebrosidase mutations are not a common risk factor for Parkinson disease in North Africa, Neuroscience Letters, vol.477, issue.2, pp.57-60, 2010.
DOI : 10.1016/j.neulet.2009.11.066

B. Bembi, Z. Marsala, S. Sidransky, E. Ciana, G. Carrozzi et al., Gaucher's disease with Parkinson's disease: Clinical and pathological aspects, Neurology, vol.61, issue.1, pp.99-101, 2003.
DOI : 10.1212/01.WNL.0000072482.70963.D7

R. Lachmann and F. Platt, Substrate reduction therapy for glycosphingolipid storage disorders, Expert Opinion on Investigational Drugs, vol.59, issue.3, pp.455-466, 2001.
DOI : 10.1046/j.1365-2141.2000.02177.x

A. Elbaz, J. Bower, B. Peterson, D. Maraganore, S. Mcdonnell et al., Survival Study of Parkinson Disease in Olmsted County, Minnesota, Archives of Neurology, vol.60, issue.1, pp.91-96, 2003.
DOI : 10.1001/archneur.60.1.91

M. Spitz, R. Rozenberg, P. Silveira, and E. Barbosa, Parkinsonism in type 1 Gaucher's disease, Journal of Neurology, Neurosurgery & Psychiatry, vol.77, issue.5, pp.709-710, 2006.
DOI : 10.1136/jnnp.2005.076240

P. Chérin, F. Sedel, C. Mignot, M. Schupbach, I. Gourfinkel-an et al., Les manifestations neurologiques de la maladie de Gaucher de type 1 : vers une remise en cause de la classification actuelle ?, Revue Neurologique, vol.162, issue.11, pp.1076-1083, 2006.
DOI : 10.1016/S0035-3787(06)75120-7

M. Balwani, L. Fuerstman, R. Kornreich, L. Edelmann, and R. Desnick, Type 1 Gaucher Disease, Archives of Internal Medicine, vol.170, issue.16, pp.1463-1469, 2010.
DOI : 10.1001/archinternmed.2010.302

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098047

S. Zuckerman, A. Lahad, A. Shmueli, A. Zimran, L. Peleg et al., Carrier Screening for Gaucher Disease, JAMA, vol.298, issue.11, pp.1281-1290, 2007.
DOI : 10.1001/jama.298.11.1281

E. Beutler, Carrier Screening for Gaucher Disease, JAMA, vol.298, issue.11, pp.1329-1331, 2007.
DOI : 10.1001/jama.298.11.1329

L. Chkioua, S. Khedhiri, B. Turkia, H. Chahed, H. Ferchichi et al., Hurler disease (mucopolysaccharidosis type IH): clinical features and consanguinity in Tunisian population, Diagnostic Pathology, vol.6, issue.1, p.113, 2011.
DOI : 10.1017/S0021932098002612

L. Chkioua, S. Khedhiri, A. Kassab, A. Bibi, S. Ferchichi et al., Molecular analysis of mucopolysaccharidosis type I in Tunisia: identification of novel mutation and eight Novel polymorphisms, Diagnostic Pathology, vol.6, issue.1, pp.39-4610, 2011.
DOI : 10.1186/1746-1596-6-11

B. Rhouma, Adult gaucher disease in southern Tunisia: report of three cases, Diagnostic Pathology 2012 7:4. Submit your next manuscript to BioMed Central and take full advantage of
URL : https://hal.archives-ouvertes.fr/pasteur-00682183