J. Gil and E. M. , Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action, APOPTOSIS, vol.5, issue.2, pp.107-114, 2000.
DOI : 10.1023/A:1009664109241

L. Cullen and G. Arndt, Genome-wide screening for gene function using RNAi in mammalian cells, Immunology and Cell Biology, vol.37, issue.3, pp.217-223, 2005.
DOI : 10.1016/j.febslet.2004.07.075

. Echeverri-cj and N. Perrimon, High-throughput RNAi screening in cultured cells: a user's guide, Nature Reviews Genetics, vol.102, issue.5, pp.373-384, 2006.
DOI : 10.1038/nrg1836

S. Zhang, B. Zhao, . Jiang-h, B. Wang, and B. Ma, Cationic lipids and polymers mediated vectors for delivery of siRNA, Journal of Controlled Release, vol.123, issue.1, pp.1-10, 2007.
DOI : 10.1016/j.jconrel.2007.07.016

J. Borawski, A. Lindeman, F. Buxton, M. Labow, and L. Gaither, Optimization Procedure for Small Interfering RNA Transfection in a 384-Well Format, Journal of Biomolecular Screening, vol.12, issue.4, pp.546-559, 2007.
DOI : 10.1177/1087057107300172

D. Rozema and D. Lewis, siRNA delivery technologies for mammalian systems, TARGETS, vol.2, issue.6, pp.253-260, 2003.
DOI : 10.1016/S1477-3627(03)02381-X

G. Arts, E. Langemeijer, R. Tissingh, L. Ma, . Pavliska-h et al., Adenoviral Vectors Expressing siRNAs for Discovery and Validation of Gene Function, Genome Research, vol.13, issue.10, pp.2325-2332, 2003.
DOI : 10.1101/gr.1332603

D. Rubinson, D. , K. Av, . Sievers-c, L. Yang et al., A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference, Nature Genetics, vol.33, issue.3, pp.401-406, 2003.
DOI : 10.1038/ng1117

E. Sachse-c and . Cj, Oncology studies using siRNA libraries: the dawn of RNAi-based genomics, Oncogene, vol.23, issue.51, pp.8384-8391, 2004.
DOI : 10.1038/sj.onc.1208072

S. Persengiev, X. Zhu, and M. Green, Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs), RNA, vol.10, issue.1, pp.12-18, 2004.
DOI : 10.1261/rna5160904

M. Sledz, M. De-veer, S. Rh, and B. Williams, Activation of the interferon system by short-interfering RNAs, Nature Cell Biology, vol.5, issue.9, pp.834-839, 2003.
DOI : 10.1038/ncb1038

. Sasaguri-y and A. Tanimoto, Role of Macrophage-derived Histamine in Atherosclerosis<BR>&mdash; Chronic Participation in the Inflammatory Response &mdash;, Journal of Atherosclerosis and Thrombosis, vol.11, issue.3, pp.122-130, 2004.
DOI : 10.5551/jat.11.122

. Agaisse-h, L. Burrack, J. Philips, E. Rubin, N. Perrimon et al., Genome-Wide RNAi Screen for Host Factors Required for Intracellular Bacterial Infection, Science, vol.309, issue.5738, pp.1248-1251, 2005.
DOI : 10.1126/science.1116008

J. Philips, E. Rubin, and N. Perrimon, Drosophila RNAi Screen Reveals CD36 Family Member Required for Mycobacterial Infection, Science, vol.309, issue.5738, pp.1251-1253, 2005.
DOI : 10.1126/science.1116006

A. Boese, P. Sommer, A. Gaussin, A. Reimann, and U. Nehrbass, Ini1/hSNF5 is dispensable for retrovirus-induced cytoplasmic accumulation of PML and does not interfere with integration, FEBS Letters, vol.20, issue.3, pp.291-296, 2004.
DOI : 10.1016/j.febslet.2004.11.016

URL : https://hal.archives-ouvertes.fr/pasteur-00850261

L. Naldini, U. Blomer, P. Gallay, D. Ory, R. Mulligan et al., In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector, Science, vol.272, issue.5259, pp.263-267, 1996.
DOI : 10.1126/science.272.5259.263

. Moon-h and A. Genovesio, IM, a computing approach for image mining of high throughput-high content screening, AcM International conference on Grid computing, 2008.

Q. Tian, S. Stepaniants, M. Mao, L. Weng, F. Mc et al., Integrated Genomic and Proteomic Analyses of Gene Expression in Mammalian Cells, Molecular & Cellular Proteomics, vol.3, issue.10, pp.960-969, 2004.
DOI : 10.1074/mcp.M400055-MCP200

L. Nie, G. Wu, and W. Zhang, Correlation between mRNA and protein abundance in Desulfovibrio vulgaris: A multiple regression to identify sources of variations, Biochemical and Biophysical Research Communications, vol.339, issue.2, pp.603-610, 2006.
DOI : 10.1016/j.bbrc.2005.11.055

G. Chen, T. Gharib, . Huang-cc, J. Taylor, D. Misek et al., Discordant Protein and mRNA Expression in Lung Adenocarcinomas, Molecular & Cellular Proteomics, vol.1, issue.4, pp.304-313, 2002.
DOI : 10.1074/mcp.M200008-MCP200

L. Pascal, L. True, D. Deutsch, E. Risk, M. Coleman et al., Correlation of mRNA and protein levels: Cell type-specific gene expression of cluster designation antigens in the prostate, BMC Genomics, vol.9, issue.1, p.246, 2008.
DOI : 10.1186/1471-2164-9-246

X. Li, X. Zhao, . Fang-y, X. Jiang, T. Duong et al., Generation of Destabilized Green Fluorescent Protein as a Transcription Reporter, Journal of Biological Chemistry, vol.273, issue.52, pp.34970-34975, 1998.
DOI : 10.1074/jbc.273.52.34970

I. Choi, B. Cho, D. Kim, S. Miyagawa, T. Kubo et al., Choice of the adequate detection time for the accurate evaluation of the efficiency of siRNA-induced gene silencing, Journal of Biotechnology, vol.120, issue.3, pp.251-261, 2005.
DOI : 10.1016/j.jbiotec.2005.06.014

I. Zuhorn, J. Engberts, and D. Hoekstra, Gene delivery by cationic lipid vectors: overcoming cellular barriers, European Biophysics Journal, vol.11, issue.4-5, pp.349-362, 2007.
DOI : 10.1007/s00249-006-0092-4

I. Khalil, K. Kogure, and . Akita-h, Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery, Pharmacological Reviews, vol.58, issue.1, pp.32-45, 2006.
DOI : 10.1124/pr.58.1.8

I. Zuhorn, . Visser-wh, U. Bakowsky, J. Engberts, and D. Hoekstra, Interference of serum with lipoplex???cell interaction: modulation of intracellular processing, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1560, issue.1-2, pp.25-36, 2002.
DOI : 10.1016/S0005-2736(01)00448-5

M. Bc, S. Zhang, . Jiang-hm, and B. Zhao, Lv hT: Lipoplex morphologies and their influences on transfection efficiency in gene delivery, J Control Release, vol.123, pp.184-194, 2007.

L. Wasungu and D. Hoekstra, Cationic lipids, lipoplexes and intracellular delivery of genes, Journal of Controlled Release, vol.116, issue.2, pp.255-264, 2006.
DOI : 10.1016/j.jconrel.2006.06.024

A. Elouahabi and J. Ruysschaert, Formation and Intracellular Trafficking of Lipoplexes and Polyplexes, Molecular Therapy, vol.11, issue.3, pp.336-347, 2005.
DOI : 10.1016/j.ymthe.2004.12.006

P. Svoboda, Off-targeting and other non-specific effects of RNAi experiments in mammalian cells Address correspondence to: Jean-Philippe Carralot Institut Pasteur Korea 39-1 Hawolgok-dong Seongbuk-gu, Curr Opin Mol Ther, vol.9, pp.248-257, 2007.