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Short report: Contribution of quantitative real-time polymerase chain reaction to follow-up of visceral leishmaniasis patients treated with meglumine antimoniate.

Abstract : Forty-two patients with visceral leishmaniasis in Tunisia were treated with meglumine antimoniate and followed-up for clinical improvement and blood parasite load determined by quantitative real-time polymerase chain reaction (PCR). Parasite loads before treatment ranged from 27 to 5.3 x 10(7) parasites/mL. At the end of treatment, parasite load decreased significantly in 39 cured patients (P < 0.001). The decrease in parasite load after treatment was greater than 99% for 34 patients and PCR results became negative in 23 of them. Two patients without clinical improvement showed no or slight decreases in parasite load (209 versus 202 parasites/mL and 1,765 versus 146 parasites/mL). One patient showed had a relapse seven months after showing a good response to treatment. His parasitemia remained high despite a sharp decrease (5.2 x 10(5) versus 5.9 x 10(3) parasites/mL).
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Submitted on : Friday, March 30, 2012 - 1:44:19 PM
Last modification on : Wednesday, August 19, 2020 - 12:08:08 PM
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Karim Aoun, Emira Chouihi, Fethi Amri, Nissaf Ben Alaya, Ali Raies, et al.. Short report: Contribution of quantitative real-time polymerase chain reaction to follow-up of visceral leishmaniasis patients treated with meglumine antimoniate.. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2009, 81 (6), pp.1004-6. ⟨10.4269/ajtmh.2009.09-0285⟩. ⟨pasteur-00684006⟩

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